Compare Nifedipine vs. Plendil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Procardia
(Nifedipine)

Plendil
(Felodipine)

Lowers blood pressure and controls heart rate. Nifedipine works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding grapefruit. You can't miss doses, and you might get persistent swelling.Lowers blood pressure. Plendil (Felodipine) works well to lower blood pressure, but it may cause swelling in your arms and legs at higher doses.
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Reviews & ratings
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Have you used Procardia (Nifedipine)?
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Have you used Plendil (Felodipine)?
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Side effects
NifedipinePlendil
  • Leg or ankle swelling 19%
  • Headache 6%
  • Dizziness 2%
  • Nausea 1%
More Nifedipine side effects »
  • Swelling 14%
  • Flushing 6%
  • Headache 5%
  • Upset stomach 3%
  • Racing heart beat 2%
  • Colds or flu 2%
  • Dizziness 1%
  • Weakness 1%
  • Constipation 1%
  • Nausea 1%
More Plendil side effects »
How it works
NifedipinePlendil
Nifedipine is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Plendil (Felodipine) is a calcium channel blocker. It lowers blood pressure by relaxing heart tissue and lowering pressure in blood vessels, which causes your blood pressure to go down.
Type of medication
NifedipinePlendil
Antihypertensive
Calcium channel blocker
Prescription only
Antihypertensive
Calcium channel blocker
Prescription only
Available as
NifedipinePlendil
  • Pill
  • Extended release
  • Extended release
Used for (click to learn more)
NifedipinePlendil
Risk factors for serious side effects
NifedipinePlendil
  • Taking anti-inflammatories, acid reducers in the stomach, anticholinergics, laxatives, levothyroxine
  • History of intestinal surgery
  • Taking beta-blockers
  • Severe coronary artery disease.
  • History of cirrhosis
Detailed risks & warnings »
  • Over age 65
  • Taking in combination with a beta-blocker
  • Liver disease
  • History of heart failure
  • History of kidney disease
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
NifedipinePlendil
No food related info.
  • Plendil (Felodipine) can be taken without food or with a light low fat meal.
Kidneys and liver
NifedipinePlendil
  • Reports of liver damage have occurred while on this medication, especially if you have had cirrhosis. Your doctor will monitor your liver on a regular basis. Tell your doctor if you or your caregivers/family notice your skin or the whites of your eyes are becoming yellower, pain in your abdomen, or sudden confusion.
No kidneys and liver related info.
Upsides and benefits
NifedipinePlendil
  • A first-choice blood pressure treatment for many people.
  • Calcium channel blockers work especially well for African Americans to lower blood pressure.
  • You can take it alone or with other medicines to help lower blood pressure.
  • Lowers the risk of heart attack and stroke.
  • Prevents heart-related chest pain (angina) if you take it regularly.
  • Treats certain abnormal heart rhythms.
  • Plendil (Felodipine) is a good option for people with high blood pressure.
  • Calcium channel blockers sometimes work better for people of African descent than other blood pressure lowering drugs.
Downsides and risks
NifedipinePlendil
  • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
  • Women are more likely to have side effects (especially swelling) from Nifedipine than men.
  • You can't miss doses. Stopping Nifedipine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Not a good medication for you if you love grapefruit. It can make Nifedipine have a stronger effect on your blood pressure.
  • Plendil (Felodipine) may not work as well as other calcium channel blockers.
  • It can lead to more swelling in your arms and legs when taken at higher doses.
  • You can't miss doses. Stopping Plendil (Felodipine) could cause a sudden spike in blood pressure.
  • Plendil (Felodipine) can't be crushed or cut into two.
Tips from our pharmacists for people taking the medication
NifedipinePlendil
  • Can cause dizziness or headaches in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Can cause face flushing and ankle or foot swelling.
  • Avoid grapefruit while taking this medicine.
  • Your doctor might do routine blood tests to check your liver function.
  • Can cause swelling in your legs or ankles.
  • Can also cause swelling in your gums.
  • Plendil (Felodipine) can be taken without food or with a light low fat meal.
  • Avoid grapefruit and grapefruit juice while taking Plendil (Felodipine).
  • You might feel lightheaded or dizzy when first starting Plendil (Felodipine).
Learn more
More about NifedipineSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Procardia (Nifedipine)?
Worth itNot sureNot worth it
More about PlendilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Plendil (Felodipine)?
Worth itNot sureNot worth it