Compare Nifedipine vs. Zestoretic

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Procardia (Nifedipine)

Prescription only
Lowers blood pressure and controls heart rate.

Nifedipine works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding grapefruit. You can't miss doses, and you might get persistent swelling.

3.7/ 7 average rating with 26 reviewsforNifedipine
Lowers blood pressure.

Lisinopril/hydrochlorothiazide is a good 2-in-1 blood pressure-lowering medicine that protects kidney function.

4.6/ 7 average rating with 294 reviewsforZestoretic
  • A first-choice blood pressure treatment for many people.
  • Calcium channel blockers work especially well for African Americans to lower blood pressure.
  • You can take it alone or with other medicines to help lower blood pressure.
  • Lowers the risk of heart attack and stroke.
  • Prevents heart-related chest pain (angina) if you take it regularly.
  • Treats certain abnormal heart rhythms.
  • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
  • The two drugs in Lisinopril/hydrochlorothiazide work together to lower blood pressure, remove extra water from your body, and lower your risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
  • Women are more likely to have side effects (especially swelling) from Nifedipine than men.
  • You can't miss doses. Stopping Nifedipine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • Not a good medication for you if you love grapefruit. It can make Nifedipine have a stronger effect on your blood pressure.
  • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
  • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Makes you urinate more often.
  • Doesn't work as well in people with severe kidney problems.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
Used for
Dosage forms
  • Pill
  • Extended release
  • Pill
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Side effects
10possible side effects
  • Dizziness, lightheadedness, giddiness
  • Flushing
  • Headache
  • Weakness
  • Nausea, heartburn
  • Muscle cramps, tremor
  • Peripheral edema
  • Nervousness, mood changes
  • Palpitation
  • Dyspnea, cough, wheezing
See more detailed side effects
10possible side effects
  • Dizziness
  • Headache
  • Cough
  • Fatigue
  • Orthostatic Effects
  • Diarrhea
  • Nausea
  • Upper Respiratory Infection
  • Muscle Cramps
  • Asthenia
See more detailed side effects
Risks and warnings
  • Intestinal blockage

    Taking anti-inflammatories, acid reducers in the stomach, anticholinergics, laxatives, levothyroxine

    ...and 1 more risk factors

  • Chest pain

    Taking beta-blockers

    ...and 1 more risk factors

  • Liver damage/jaundice

    History of cirrhosis

  • Congestive heart failure

    History of tight aortic stenosis

    ...and 1 more risk factors

  • Heart attack or increased chest pain

    Obstructive coronary artery disease

See more detailed risks and warnings
  • Harm to fetus

    Women of childbearing age

  • Unusual tongue swelling

    African descent

  • Severe allergic reactions while on dialysis

    People requiring high flux dialysis

  • Acute kidney failure

    History of kidney disease

  • Heart problems due to high potassium

    Current kidney problems

    ...and 2 more risk factors

See more detailed risks and warnings