Compare Nifedipine vs. Zestoretic

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Procardia
(Nifedipine)

Zestoretic
(Lisinopril / Hydrochlorothiazide)

Lowers blood pressure and controls heart rate. Nifedipine works well to lower blood pressure and prevent chest pain, but you have to be okay with avoiding grapefruit. You can't miss doses, and you might get persistent swelling.Lowers blood pressure. Lisinopril/hydrochlorothiazide is a good 2-in-1 blood pressure-lowering medicine that protects kidney function.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
3.6Nifedipine
Reviews for Procardia (Nifedipine)
40%
of people say Procardia (Nifedipine) is worth it
28%
say it works well
48%
say it's a big hassle
Reviews for Zestoretic (Lisinopril / Hydrochlorothiazide)
51%
+11% vs. Procardia (Nifedipine)
40%
+12% vs. Procardia (Nifedipine)
17%
+31% vs. Procardia (Nifedipine)
Side effects
NifedipineZestoretic
  • Leg or ankle swelling 19%
  • Flushing 17%
  • Dizziness, lightheadedness, giddiness 12%
  • Muscle cramps, tremor 5%
  • Nervousness, mood changes 3%
  • Headache 3%
  • Dyspnea, cough, wheezing 3%
  • Nausea, heartburn 3%
  • Heart pounding or racing sensation 2%
  • Dizziness 2%
More Nifedipine side effects »
  • Dizziness 6%
  • Headache 3%
  • Cough 3%
  • Fatigue 3%
  • Orthostatic effects 2%
  • Muscle weakness 1%
  • Diarrhea 1%
More Zestoretic side effects »
How it works
NifedipineZestoretic
Nifedipine is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Lisinopril/hydrochlorothiazide is a combination medicine. Lisinopril (an ACE inhibitor) lowers blood pressure by making blood vessels relax. Hydrochlorothiazide (a diuretic or water pill) lowers blood pressure and swelling by removing extra fluid from your body.
Type of medication
NifedipineZestoretic
Antihypertensive
Calcium channel blocker
Prescription only
Antihypertensive
ACE inhibitor
Diuretic
Prescription only
Available as
NifedipineZestoretic
  • Pill
  • Extended release
  • Pill
Used for (click to learn more)
NifedipineZestoretic
Risk factors for serious side effects
NifedipineZestoretic
  • Taking anti-inflammatories, acid reducers in the stomach, anticholinergics, laxatives, levothyroxine
  • History of intestinal surgery
  • Taking beta-blockers
  • Severe coronary artery disease.
  • History of cirrhosis
    • History of tight aortic stenosis
    • Taking beta-blockers
    • Obstructive coronary artery disease
    Detailed Procardia (Nifedipine) risks & warnings »
    • Women of childbearing age
    • African descent
    • People requiring high flux dialysis
    • History of kidney disease
    • Current kidney problems
    • Medicine that increase potassium
    • Use of salt substitute
      Detailed Zestoretic (Lisinopril / Hydrochlorothiazide) risks & warnings »
      Pregnancy category
      NifedipineZestoretic
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      DFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.
      • Doesn't work as well in people with severe kidney problems.
      • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
      • Requires routine blood tests to check kidney function.
      • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause severe allergic reactions, including death, to patients who required certain types of kidney dialysis. Talk to your prescriber if you are undergoing dialysis to discuss possible alternative medications.
      • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause kidney damage, especially if you already have a history of kidney disease. Talk to your doctor to discuss possible alternatives if this is a concern.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      NifedipineZestoretic
      • A first-choice blood pressure treatment for many people.
      • Calcium channel blockers work especially well for African Americans to lower blood pressure.
      • You can take it alone or with other medicines to help lower blood pressure.
      • Lowers the risk of heart attack and stroke.
      • Prevents heart-related chest pain (angina) if you take it regularly.
      • Treats certain abnormal heart rhythms.
      • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
      • The two drugs in Lisinopril/hydrochlorothiazide work together to lower blood pressure, remove extra water from your body, and lower your risk of heart attack and stroke.
      • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
      • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
      Downsides and risks
      NifedipineZestoretic
      • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
      • Women are more likely to have side effects (especially swelling) from Nifedipine than men.
      • You can't miss doses. Stopping Nifedipine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
      • Not a good medication for you if you love grapefruit. It can make Nifedipine have a stronger effect on your blood pressure.
      • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
      • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
      • Makes you urinate more often.
      • Doesn't work as well in people with severe kidney problems.
      • Requires a yearly blood test to see how the medicine is affecting your body.
      • Not safe to use if you're pregnant.
      Tips from our pharmacists for people taking the medication
      NifedipineZestoretic
      • Can cause dizziness or headaches in the first few days.
      • Can cause face flushing and ankle or foot swelling.
      • Avoid grapefruit while taking this medicine.
      • Your doctor might do routine blood tests to check your liver function.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      • Makes you urinate more often, so avoid taking it at bedtime.
      • Can cause dizziness in the first few days.
      • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
      • Requires routine blood tests to check kidney function.
      • Don't take it if you're pregnant.
      • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
      Learn more
      More about NifedipineSide effectsReviews & ratingsAlternativesFDA package insert
      More about ZestoreticSide effectsReviews & ratingsAlternativesFDA package insert