Compare Norco vs. Morphine Sulfate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats moderate to moderately severe pain.

Norco (hydrocodone / acetaminophen) is a good option to treat pain when over-the-counter medicines haven't worked, but it can lead to dependence and tolerance if taken for a long time.

3.7/ 5 average rating with 1194 reviewsforNorco
Treats severe pain.

Ms Contin (Morphine Sulfate) provides good long-term pain control without the need to take medicine frequently, but watch out for constipation.

3.5/ 5 average rating with 541 reviewsforMorphine Sulfate
Upsides
  • Norco (hydrocodone / acetaminophen) has two medicines to treat moderate to moderately severe pain. The combination is more effective than either drug alone.
  • Norco (hydrocodone / acetaminophen) is more potent than many over-the-counter options.
  • You can take this with or without food.
  • This medicine also comes as a liquid if you have trouble swallowing.
  • Norco (hydrocodone / acetaminophen) is available as a generic.
  • Provides longer relieve for moderate to severe pain to improve quality of life.
  • Good for chronic pain that requires around-the-clock relief.
  • Might have fewer side effects than other opioid pain relievers.
Downsides
  • Constipation, dizziness, drowsiness, and nausea can commonly occur.
  • Since Norco (hydrocodone / acetaminophen) is a controlled medication, it cannot be refilled or transferred to another pharmacy.
  • Long-term use can cause dependence and tolerance.
  • Too much Norco (hydrocodone / acetaminophen) can damage the liver.
  • Not effective in treating all kinds of pain.
  • Doesn't work for as-needed or quick pain relief.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Ms Contin (Morphine Sulfate) if you need.
  • Long term use will likely cause physical dependence.
  • Must be weaned slowly off the medicine after use longer than 2 weeks.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Extended release
  • Oral solution
  • Liquid
  • Suppository
Price
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Reviews
1194 reviews so far
67%
saidit'sworth it
44%
saiditworked well
13%
saidit'sa big hassle

Have you used Norco (hydrocodone / acetaminophen)?

Leave a review
541 reviews so far
55%
saidit'sworth it
43%
saiditworked well
20%
saidit'sa big hassle

Have you used Ms Contin (Morphine Sulfate)?

Leave a review
Side effects
The Norco (hydrocodone / acetaminophen) FDA package insert doesn’t have numbers about how common side effects are.
The Ms Contin (Morphine Sulfate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Liver failure
    • Current liver disease
    • Taking Norco (hydrocodone / acetaminophen) with alcohol
    • Taking other medicines containing acetaminophen
  • Slowed breathing
    • Age 65 or greater
    • High dosages
    • History of lung problems
    • Taking other painkillers or sedatives
  • Severe allergic reactions
    • Taking more than the prescribed dose
    • Long-term use
    • History of substance abuse
    • Younger age
  • Tolerance, dependence, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
    • Younger age
  • Constipation
    • Age 65 or greater
    • Long-term use of opioids
    • Taking drugs that cause constipation
  • Confusion and drowsiness
    • Drinking alcohol
    • Age 65 years or older
See more detailed risks and warnings
  • Death from lack of oxygen to the body (respiratory depression)
    • Current use of medicine that affects liver enzyme CYP 3A4
    • Age 65 or greater
    • Higher dose
    • People with not enough thyroid hormones
    • History of lung problems
  • Death from overdose
    • Children age 18 and younger
  • Death in newborn babies from opioid withdrawal (Neonatal opioid withdrawal syndrome)
    • Long-term use during pregnancy
  • Tolerance, dependence, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
  • Low blood pressure
    • Age 65 years or older
See more detailed risks and warnings
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Disclaimer: We don't provide medical advice. If you think you might have a medical emergency, call your doctor or 911 immediately.