Compare Norflex vs. Zanaflex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Norflex
(orphenadrine)

Zanaflex
(tizanidine)

Coming soon.Relaxes your muscles. Zanaflex (tizanidine) isn't a first-choice treatment for muscle spasticity. Try other options before using this.
Reviews & ratings
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Have you used Norflex (orphenadrine)?
Worth itNot sureNot worth it
Reviews for Zanaflex
81%
-41% worse vs. Norflex
73%
-53% worse vs. Norflex
19%
-1% worse vs. Norflex
Have you used Zanaflex (tizanidine)?
Worth itNot sureNot worth it
Side effects
NorflexZanaflex

We haven’t found good data for Norflex side effects.

FDA side effect reports for Norflex »
  • Dry mouth 39%
  • Sleepiness 38%
  • Weakness 25%
  • Dizziness 12%
  • Urinary tract infection 3%
  • General infection 1%
  • Liver test abnormality 4%
  • Constipation 3%
  • Hay fever 1%
  • Speech disorder 3%
More Zanaflex side effects »
How it works
NorflexZanaflex
Coming soon.Zanaflex (tizanidine) is an alpha2-adrenergic agonist that works in the nervous system to calm down muscle spasticity.
Type of medication
NorflexZanaflex
Prescription only
Available as
NorflexZanaflex
  • Extended release
  • Pill
Used for
NorflexZanaflex
  • Musculoskeletal Pain
Risk factors for serious side effects
NorflexZanaflex
    Coming soon.
    • Taking maximum doses of Zanaflex (tizanidine)
    • Age 65 years or older
    • Currently on blood pressure control medications
    • Taking other medications that also cause sleepiness
    • Recreational drug use
    Detailed Zanaflex (tizanidine) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Food
    NorflexZanaflex
    No food related info.
    • Can be taken with or without food, but you need to be consistent since food affects how the medication is absorbed and works.
    • Need to be consistent every day in taking this with or without food.
    Sleep
    NorflexZanaflex
    No sleep related info.
    • Taking Zanaflex (tizanidine) can make you feel sleepy and dizzy, especially if you're taking other medications that can also make you feel sleepy, or if you're taking recreational drugs or drinking too much alcohol. Avoid driving or doing other tasks that require concentration until you know how this medication affects you.
    • Can cause dizziness, fatigue, drowsiness, and dry mouth.
    Upsides and benefits
    NorflexZanaflex
    Coming soon
    • Relieves muscle spasticity.
    • Available as a generic.
    • Available in a tablet or capsule form. It also comes in a capsule that can be opened and sprinkled in applesauce for people that can't swallow pills.
    Downsides and risks
    NorflexZanaflex
    Coming soon
    • This isn't a first-choice muscle relaxing medication. Other drugs work better and have fewer side effects.
    • Takes over an hour to kick in and only lasts 3 to 6 hours.
    • Zanaflex (tizanidine) can lower blood pressure, so be careful if you are already on a blood pressure medication.
    • Need to be consistent every day in taking this with or without food.
    • Elderly individuals have more side effects when taking Zanaflex (tizanidine).
    Tips from our pharmacists for people taking the medication
    NorflexZanaflex
    Coming soon
    • Can cause dizziness, fatigue, drowsiness, and dry mouth.
    • Avoid activities requiring mental alertness (like driving) until you know how it affects you.
    • Can be taken with or without food, but you need to be consistent since food affects how the medication is absorbed and works.
    • The tablets are not the same as the capsules. This could mean differences in how your body reacts to it, or how it works for you.
    • If you have been on Zanaflex (tizanidine) for a long period of time, you should not stop this abruptly. This can result in rebound high blood pressure, muscle spasticity or fast heart beat. Talk to your doctor about how to slowly lower your dose.
    Learn more
    More about NorflexSide effectsReviews & ratingsFDA package insert
    Have you used Norflex (orphenadrine)?
    Worth itNot sureNot worth it
    More about ZanaflexSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Zanaflex (tizanidine)?
    Worth itNot sureNot worth it