Compare desipramine vs. Celexa

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Norpramin (desipramine)

Prescription only

Celexa (citalopram)

Prescription only
Stabilizes your mood.

Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.

Improves mood.

Celexa (citalopram) is good for treating depression and anxiety. Side effects are less likely to happen compared to other antidepressants; however, it is not the best choice for people with heart or liver problems.

5.0/ 7 average rating with 520 reviewsforCelexa
Upsides
  • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
  • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
  • Effectively relieves depression symptoms.
  • This medicine is not as drowsy as other antidepressants.
  • Available as a generic, which is cheaper.
Downsides
  • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
  • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
  • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
  • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
  • Not recommended in children under 12 years of age.
  • Can cause sexual side effects like decreased sex drive, difficulties with orgasm or ejaculation, and minor weight gain (1 to 5 pounds).
  • Celexa (citalopram) may not be a good option if you have heart or liver problems.
  • Like most antidepressants, Celexa (citalopram) can increase risk of suicidal thoughts and behavior in people younger than 24 years.
Used for
Dosage forms
  • Pill
  • Pill
  • Liquid
Price
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$15.87
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$4
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Reviews
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520 
61%
think this treatment is worth it
51%
think this treatment works well
16%
think this treatment is a hassle

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Side effects
The Norpramin (desipramine) FDA package insert doesn’t have numbers about how common side effects are.
The Celexa (citalopram) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Higher risk of suicide

    People under age 24

  • Serotonin syndrome

    Tricyclic antidepressants

    ...and 5 more risk factors

  • Changes to the heartbeat

    History of heart disease

  • Higher risk for seizures

    History of seizures

    ...and 1 more risk factors

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Serotonin syndrome

    Taking tricyclic antidepressants, lithium, tramadol, fentanyl, amphetamines, certain headache medications (triptans), St. John's Wort

  • Bipolar disorder

    History of bipolar disorder

    ...and 1 more risk factors

  • Withdrawal

    Stopping Celexa (citalopram) abruptly

  • Lower maximum dose in some people

    Higher dose

    ...and 3 more risk factors

  • Increased bleeding

    Taking other blood-thinning drugs (including aspirin, NSAIDs such as Advil, warfarin)

See more detailed risks and warnings