Compare Norpramin vs. Effexor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Norpramin
(Desipramine)

Effexor
(Venlafaxine)

Coming soon.Improves mood and helps you relax. Effexor (Venlafaxine) is good for treating depression and anxiety. May work when other antidepressants haven't, it's but more likely to cause side effects and withdrawal symptoms than other antidepressants.
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Reviews & ratings
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Reviews for Effexor (Venlafaxine)
61%
39% vs. Norpramin (Desipramine)
50%
50% vs. Norpramin (Desipramine)
22%
22% vs. Norpramin (Desipramine)
Side effects
NorpraminEffexor

We haven’t found good data for Norpramin side effects.

FDA side effect reports for Norpramin »
  • Nausea 42%
  • Drowsiness 22%
  • Dizziness 20%
  • Nervousness 17%
  • Sleep difficulty 16%
  • Loss of appetite 15%
  • Sweating 14%
  • Dry mouth 13%
  • Dry mouth 11%
  • Muscle weakness 10%
More Effexor side effects »
How it works
NorpraminEffexor
Coming soon.Effexor (Venlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulate mood.
Type of medication
NorpraminEffexor
Coming soon.
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Available as
NorpraminEffexor
  • Pill
  • Pill
  • Extended release
Used for (click to learn more)
NorpraminEffexor
  • Depression
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Norpramin (Desipramine)

After 4 weeks using Start and Effexor (Venlafaxine), here’s how much better people feel.

Risk factors for serious side effects
NorpraminEffexor
Coming soon.
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Effexor (Venlafaxine) suddenly
  • History of high blood pressure
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
    Detailed Effexor (Venlafaxine) risks & warnings »
    Pregnancy category
    NorpraminEffexor
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.
    • You can take the extended-release form once a day with food either in the morning or in the evening at about the same time each day.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.
    • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
    • Effexor (Venlafaxine) can cause lower sex drive or difficulty having an orgasm. If the problem persists after the first 2 to 3 months, you can talk to your doctor about alternative antidepressants or performance-enhancing medications.
    Sleep
    No specific sleep-related info.
    • Causes more sleepiness than other antidepressants, so it's good for people who have trouble sleeping.
    • Stopping Effexor (Venlafaxine) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3 days of stopping the medication, and go away within 1 to 2 weeks. Work with your doctor to gradually reduce your dose.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    NorpraminEffexor
    Coming soon.
    • Effective at relieving depression and anxiety symptoms.
    • Lowers relapse rates of depression.
    • Causes more sleepiness than other antidepressants, so it's good for people who have trouble sleeping.
    • Six out of ten people who use an antidepressant for the first time find that it works for them.
    • Might work when other antidepressants haven't worked since it affects two chemicals in the brain that impact your mood. Many other antidepressants affect only serotonin, but not norepinephrine too.
    Downsides and risks
    NorpraminEffexor
    Coming soon.
    • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
    • Not the best option for people with high blood pressure.
    • Overdosing on this medication could be fatal.
    • It's more likely to cause nausea and vomiting or make you feel sick if you miss a dose than other antidepressants. Also causes more sleepiness than others.
    • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
    • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
    Tips from our pharmacists for people taking the medication
    NorpraminEffexor
    Coming soon.
    • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
    • You can take the extended-release form once a day with food either in the morning or in the evening at about the same time each day.
    • Extended-release capsules should be swallowed whole. If you can’t swallow pills, open the capsule, sprinkle it on a spoonful of applesauce and then swallow it without chewing.
    • Stop taking it slowly to avoid getting withdrawal symptoms.
    • Tell your doctor if you notice sudden mood changes or unusual thoughts.
    Learn more
    More about NorpraminSide effectsReviews & ratingsFDA package insert
    More about EffexorSide effectsReviews & ratingsAlternativesFDA package insert