Compare desipramine vs. Effexor

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Norpramin (desipramine)

Prescription only

Effexor (venlafaxine)

Prescription only
Stabilizes your mood.

Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.

Improves mood and helps you relax.

Effexor (venlafaxine) is good for treating depression and anxiety, but it can cause more withdrawal symptoms if you stop suddenly compared to other antidepressants.

3.7/ 5 average rating with 577 reviewsforEffexor
Upsides
  • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
  • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
  • Effexor (venlafaxine) effectively treats depression, anxiety, and panic disorder.
  • Effexor (venlafaxine) causes more sleepiness than other antidepressants, so it's beneficial for people who have trouble sleeping.
  • Effexor (venlafaxine) might work when other antidepressants haven't worked since it affects two chemicals in the brain that impact your mood.
  • Effexor (venlafaxine) has several uses, which may be good for people with multiple conditions.
  • Effexor (venlafaxine) is available in generic, which is cheaper.
Downsides
  • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
  • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
  • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
  • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
  • Not recommended in children under 12 years of age.
  • Effexor (venlafaxine) can cause side effects such as decreased libido and increased blood pressure.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people aged 24 years or younger.
  • Compared to other antidepressants, it's more likely to cause unpleasant withdrawal symptoms if you suddenly stop taking it and can causes more sleepiness.
Used for
Dosage forms
  • Pill
  • Pill
  • Extended release
Price
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Reviews
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577 reviews so far
62%
saidit'sworth it
51%
saiditworked well
23%
saidit'sa big hassle

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Side effects
The Norpramin (desipramine) FDA package insert doesn’t have numbers about how common side effects are.
39possible side effects
  • Nausea
    37%
  • Headache
    25%
  • Drowsiness
    23%
  • Dry mouth
    22%
  • Dizziness
    19%
  • Difficulty sleeping
    18%
  • Constipation
    15%
  • Nervousness
    13%
  • Weakness
    12%
  • Sweating
    12%
  • Abnormal ejaculation/orgasm
    12%
  • Loss of appetite
    11%
  • Diarrhea
    8%
  • Infection
    6%
  • Vomiting
    6%
  • Anxiety
    6%
  • Blurred vision
    6%
  • Impotence
    6%
  • Indigestion
    5%
  • Tremor
    5%
  • Abnormal dreams
    4%
  • Chills
    3%
  • Rash
    3%
  • Gas
    3%
  • Stiff muscles
    3%
  • Prickling/burning sensation
    3%
  • Yawn
    3%
  • Increased urination
    3%
  • Chest pain
    2%
  • Trauma
    2%
  • Increased blood pressure
    2%
  • Increased heart rate
    2%
  • Decreased libido
    2%
  • Agitation
    2%
  • Confusion
    2%
  • Thinking abnormal
    2%
  • Changes in taste
    2%
  • Ringing in the ears
    2%
  • Dilation of pupils
    2%
See more detailed side effects
Risks and risk factors
  • Higher risk of suicide
    • People under age 24
  • Possible bipolar disorder
  • Serotonin syndrome
    • Tricyclic antidepressants
    • Fentanyl
    • Tramadol
    • Buspirone
    • ADHD medicines
    • Triptans
  • Changes to the heartbeat
    • History of heart disease
  • Higher risk for seizures
    • History of seizures
    • History of brain damage or alcohol withdrawal
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Serotonin syndrome
    • Taking tricyclic antidepressants, lithium, tramadol, fentanyl, amphetamines, certain headache medications (triptans), St. John's Wort
  • Withdrawal
    • Stopping Effexor (venlafaxine) suddenly
  • Increased bleeding
    • Taking other blood-thinning drugs (including aspirin, NSAIDs such as Advil, warfarin)
  • Increased blood pressure
    • Bipolar disorder
      • History of bipolar disorder
      • At risk for bipolar disorder
    See more detailed risks and warnings