Compare desipramine vs. Neurontin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Norpramin (desipramine)

Prescription only

Neurontin (gabapentin)

Prescription only
Stabilizes your mood.

Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.

Treats tingling and burning nerve pain.

Neurontin (gabapentin) is an old seizure disorder medicine that is now used to treat nerve-related pain caused by different conditions.

4.6/ 7 average rating with 620 reviewsforNeurontin
Upsides
  • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
  • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
  • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
  • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
  • It's available as a generic, so it's less expensive than similar medications.
Downsides
  • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
  • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
  • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
  • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
  • Not recommended in children under 12 years of age.
  • Neurontin (gabapentin) can cause some side effects, including memory problems, drowsiness, dizziness, or confusion. There is a higher risk for these side effects if you drink alcohol, so it might not be the best medication for heavy drinkers.
  • You can't skip or miss doses since suddenly stopping Neurontin (gabapentin) can cause seizures.
Used for
Dosage forms
  • Pill
  • Pill
  • Oral solution
  • Extended release
Price
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$15.87
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Lowest price near you
$12.05
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Reviews
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620 
57%
think this treatment is worth it
40%
think this treatment works well
19%
think this treatment is a hassle

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Side effects
The Norpramin (desipramine) FDA package insert doesn’t have numbers about how common side effects are.
The Neurontin (gabapentin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Higher risk of suicide

    People under age 24

  • Serotonin syndrome

    Tricyclic antidepressants

    ...and 5 more risk factors

  • Changes to the heartbeat

    History of heart disease

  • Higher risk for seizures

    History of seizures

    ...and 1 more risk factors

See more detailed risks and warnings
  • Neurologic and psychiatric side effects (children)

    Children ages 3 to 12

  • Driving impairment

    Taking Neurontin (gabapentin) with alcohol

    ...and 1 more risk factors

  • Withdrawal seizures

    Stopping Neurontin (gabapentin) suddenly

See more detailed risks and warnings