Compare desipramine vs. Paxil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Norpramin (desipramine)

Prescription only

Paxil (paroxetine)

Prescription only
Stabilizes your mood.

Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.

Improves mood and anxiety.

Paxil (paroxetine) is effective for treating depression and anxiety, but causes more unwanted side-effects than other medicines that work like it.

4.5/ 7 average rating with 694 reviewsforPaxil
Upsides
  • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
  • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
  • Available in a cheaper, generic form.
  • Is convenient and can take once a day.
Downsides
  • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
  • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
  • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
  • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
  • Not recommended in children under 12 years of age.
  • More likely to decrease your sexual appetite and delay or prevent ejaculation than other antidepressants.
  • Like most antidepressants, Paxil (paroxetine) has a high risk of suicidal thoughts and behavior when used in children and adolescents.
  • May not be appropriate for you if you are elderly or suffer from dementia.
Used for
Dosage forms
  • Pill
  • Pill
  • Extended release pill
  • Liquid
Price
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$15.87
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$4
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Reviews
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694 
52%
think this treatment is worth it
39%
think this treatment works well
24%
think this treatment is a hassle

Have you used Paxil (paroxetine)?

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Side effects
The Norpramin (desipramine) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Abnormal ejaculation
    28%
  • Nausea
    25%
  • Weakness
    22%
  • Drowsiness
    22%
  • Difficulty sleeping
    21%
  • Decreased sexual appetite
    12%
  • Dizziness
    11%
  • Sweating
    9%
  • Dry mouth
    9%
  • Diarrhea
    9%
See more detailed side effects
Risks and warnings
  • Higher risk of suicide

    People under age 24

  • Serotonin syndrome

    Tricyclic antidepressants

    ...and 5 more risk factors

  • Changes to the heartbeat

    History of heart disease

  • Higher risk for seizures

    History of seizures

    ...and 1 more risk factors

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • High levels of serotonin (Serotonin Syndrome)

    Using other medications that affect serotonin levels

  • Withdrawal

    Stopping Paxil (paroxetine) suddenly

  • Increased bleeding risk

    Taking other blood-thinning drugs

See more detailed risks and warnings