Compare desipramine vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Norpramin
(desipramine)

Remeron
(mirtazapine)

Stabilizes your mood. Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.Improves mood. Remeron (mirtazapine) improves your mood and helps you sleep better, but can cause more weight gain than any other antidepressant.
Reviews & ratings
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Have you used Norpramin (desipramine)?
Worth itNot sureNot worth it
Reviews for Remeron
45%
-45% worse vs. desipramine
39%
-39% worse vs. desipramine
26%
+26% better vs. desipramine
152 reviews
Have you used Remeron (mirtazapine)?
Worth itNot sureNot worth it
Side effects
desipramineRemeron

The desipramine FDA package insert doesn’t have numbers about how common side effects are.

More about desipramine side effects »
  • Sleepiness 36%
  • Dry mouth 10%
  • Increased appetite   15%
  • Increased appetite 15%
  • Constipation 6%
  • Weight gain 10%
  • Lack of energy 3%
  • Dizziness 4%
  • Flu syndrome 2%
  • Abnormal dreams 3%
More Remeron side effects »
How it works
desipramineRemeron
Norpramin (desipramine) is a tricyclic antidepressant. It increases the amount of norepinephrine and serotonin in the brain, two chemicals that regulate mood.Remeron (mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.
Type of medication
desipramineRemeron
Prescription onlyPrescription only
Available as
desipramineRemeron
  • Pill
  • Pill
  • Dissolving tablet
Used for
desipramineRemeron
Risk factors for serious side effects
desipramineRemeron
  • People under age 24
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
Detailed Norpramin (desipramine) risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • History of heart problems
  • History of liver problems
  • Higher dose
Detailed Remeron (mirtazapine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Interactions
desipramineRemeron
No interactions related info.
  • Prescription medications can interact with Remeron (mirtazapine). Let your doctor or pharmacist know if you're on prescription medications currently or within the past 14 days.
Sleep
desipramineRemeron
No sleep related info.
  • Remeron (mirtazapine) can make you sleepy. It is best to take at bedtime.
  • Can help you fall asleep if you have trouble sleeping.
  • Makes you more tired than other antidepressants.
Weight
desipramineRemeron
No weight related info.
  • Remeron (mirtazapine) can raise your appetite and cause you to gain weight. Remeron (mirtazapine) can also raise your cholesterol.
  • Remeron (mirtazapine) can increase your appetite and cause to you to gain weight.
  • Good option if you are underweight or frail, because it can help you gain weight.
  • More likely to cause minor weight gain (1-5 pounds) and raise cholesterol than any other antidepressant.
Upsides and benefits
desipramineRemeron
  • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
  • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
  • Effective at relieving some depression symptoms.
  • Starts to work more quickly than most antidepressants.
  • Can help you fall asleep if you have trouble sleeping.
  • Can also help relieve anxiety.
  • Good option if you are underweight or frail, because it can help you gain weight.
  • Available as a generic.
Downsides and risks
desipramineRemeron
  • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
  • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
  • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
  • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
  • Not recommended in children under 12 years of age.
  • Makes you more tired than other antidepressants.
  • More likely to cause minor weight gain (1-5 pounds) and raise cholesterol than any other antidepressant.
Tips from our pharmacists for people taking the medication
desipramineRemeron
  • Don't drive or do anything requiring concentration until you know how Norpramin (desipramine) affects you since it can make you feel sleepy.
  • Talk to your doctor right away if your mood suddenly darkens and you want to hurt yourself while taking Norpramin (desipramine).
  • If you're being switched to Norpramin (desipramine) from monoamine oxidase inhibitors, you'll need to wait 2 weeks before you can start it.
  • Don't stop taking Norpramin (desipramine) suddenly without talking to your doctor first.
  • Remeron (mirtazapine) can make you sleepy. It is best to take at bedtime.
  • Remeron (mirtazapine) can increase your appetite and cause to you to gain weight.
  • You should not abruptly stop Remeron (mirtazapine) as this could cause serious side effects.
  • Prescription medications can interact with Remeron (mirtazapine). Let your doctor or pharmacist know if you're on prescription medications currently or within the past 14 days.
  • Remeron (mirtazapine) should be protected from light. Keep it in it's original package until ready to use.
  • Remeron (mirtazapine) can cause dry mouth. Try using sugar-free gum or candy to help with dry mouth.
Learn more
More about desipramineSide effectsAlternativesFDA package insert
Have you used Norpramin (desipramine)?
Worth itNot sureNot worth it
More about RemeronSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Remeron (mirtazapine)?
Worth itNot sureNot worth it