Compare desipramine vs. Tegretol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Norpramin (desipramine)

Prescription only

Tegretol (Carbamazepine)

Prescription only
Stabilizes your mood.

Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.

Prevents seizures, stabilizes mood, and relieves nerve pain.

Tegretol (Carbamazepine) is useful for preventing seizures and relieving certain types of nerve pain, but interacts with many drugs.

3.3/ 5 average rating with 61 reviewsforTegretol
Upsides
  • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
  • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
  • Lowers the frequency of seizures, especially for people with tonic-clonic and partial seizures.
  • First-line option for trigeminal neuralgia (nerve pain involving the face, head, and neck), and can relieve other types of nerve pain.
  • May be helpful in stabilizing mood for people with bipolar disorder.
Downsides
  • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
  • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
  • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
  • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
  • Not recommended in children under 12 years of age.
  • Interacts with many other medicines and supplements.
  • Higher risk of skin reactions compared to other antiepileptic medicines, ranging from mild to life-threatening rash.
  • Can cause blurry vision, dizziness, and upset stomach.
  • Not safe to use if you're pregnant.
  • Requires routine blood tests to see how the medicine is affecting your body.
Used for
Dosage forms
  • Pill
  • Pill
  • Extended release
  • Chewable tablet
  • Oral suspension
Price
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Reviews
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61 reviews so far
56%
saidit'sworth it
43%
saiditworked well
23%
saidit'sa big hassle

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Side effects
The Norpramin (desipramine) FDA package insert doesn’t have numbers about how common side effects are.
18possible side effects
  • Dizziness
    44%
  • Somnolence
    32%
  • Nausea
    28%
  • Vomiting
    18%
  • Ataxia
    15%
  • Constipation
    10%
  • Pruritus
    8%
  • Dry Mouth
    8%
  • Asthenia
    8%
  • Rash
    7%
  • Blurred vision
    6%
  • Speech Disorder
    6%
  • Hypertension
    3%
  • Tremor
    3%
  • Paresthesia
    2%
  • Thinking abnormal
    2%
  • Twitching
    2%
  • Vertigo
    2%
See more detailed side effects
Risks and risk factors
  • Higher risk of suicide
    • People under age 24
  • Possible bipolar disorder
  • Serotonin syndrome
    • Tricyclic antidepressants
    • Fentanyl
    • Tramadol
    • Buspirone
    • ADHD medicines
    • Triptans
  • Changes to the heartbeat
    • History of heart disease
  • Higher risk for seizures
    • History of seizures
    • History of brain damage or alcohol withdrawal
See more detailed risks and warnings
  • Serious skin rash
    • People also taking Depakote
    • Asian ancestry
  • Blood disorders
  • Suicidal thoughts or behavior
    • History of depression
  • Serious allergic reactions
    • European, Chinese, or Japanese ancestry
  • Pregnancy
  • Mental changes due to low sodium
    • Age 65 years or older
  • Withdrawal seizures
    • Stopping Tegretol (Carbamazepine) suddenly
See more detailed risks and warnings