Compare desipramine vs. Tofranil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Norpramin
(desipramine)

Tofranil
(imipramine hydrochloride)

Stabilizes your mood. Norpramin (desipramine) is not a first choice for treating depression because of its effects on the heart, but it can be good if other medicines haven't worked.Coming soon.
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Prices and coupon for 30 (10mg) tablets of desipramine
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Prices and coupon for 30 (25mg) tablets of imipramine hydrochloride
Reviews & ratings
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Have you used Norpramin (desipramine)?
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Have you used Tofranil (imipramine hydrochloride)?
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Side effects
desipramineTofranil

The desipramine FDA package insert doesn’t have numbers about how common side effects are.

More about desipramine side effects »

We haven’t found good data for Tofranil side effects.

FDA side effect reports for Tofranil »
How it works
desipramineTofranil
Norpramin (desipramine) is a tricyclic antidepressant. It increases the amount of norepinephrine and serotonin in the brain, two chemicals that regulate mood.Coming soon.
Type of medication
desipramineTofranil
Prescription only
Available as
desipramineTofranil
  • Pill
  • Pill
Used for
desipramineTofranil
  • Depression Nocturnal Enuresis
Risk factors for serious side effects
desipramineTofranil
  • People under age 24
    • Tricyclic antidepressants
    • Fentanyl
    • Tramadol
    • Buspirone
    • ADHD medicines
    • Triptans
    • History of heart disease
    • History of seizures
    • History of brain damage or alcohol withdrawal
    Detailed Norpramin (desipramine) risks & warnings »
    Coming soon.
    Pregnancy

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Upsides and benefits
    desipramineTofranil
    • Norpramin (desipramine) is available in generic and in many different strengths, so the dose can be more customized.
    • Norpramin (desipramine) has fewer side effects than similar tricyclic antidepressants.
    Coming soon
    Downsides and risks
    desipramineTofranil
    • Norpramin (desipramine) isn't recommended if you or your family has heart disease, seizures, or glaucoma.
    • Norpramin (desipramine) isn't a first choice for depression because it has more side effects than other antidepressants.
    • In some people, Norpramin (desipramine) can make you sleepy. In other people, Norpramin (desipramine) can keep you awake.
    • If you have diabetes, Norpramin (desipramine) can make your blood sugar go up.
    • Not recommended in children under 12 years of age.
    Coming soon
    Tips from our pharmacists for people taking the medication
    desipramineTofranil
    • Don't drive or do anything requiring concentration until you know how Norpramin (desipramine) affects you since it can make you feel sleepy.
    • Talk to your doctor right away if your mood suddenly darkens and you want to hurt yourself while taking Norpramin (desipramine).
    • If you're being switched to Norpramin (desipramine) from monoamine oxidase inhibitors, you'll need to wait 2 weeks before you can start it.
    • Don't stop taking Norpramin (desipramine) suddenly without talking to your doctor first.
    Coming soon
    Learn more
    More about desipramineSide effectsAlternativesFDA package insert
    Have you used Norpramin (desipramine)?
    Worth itNot sureNot worth it
    More about TofranilSide effectsReviews & ratingsFDA package insert
    Have you used Tofranil (imipramine hydrochloride)?
    Worth itNot sureNot worth it