Compare Norvasc vs. Bisoprolol

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Lowers blood pressure. Norvasc (Amlodipine) works well to lower blood pressure and prevent chest pain. You can't miss doses, and you might get persistent swelling.Lowers blood pressure. Zebeta (Bisoprolol) is usually given to people who have taken other blood pressure meds unsuccessfully or have recently had significant heart problems.
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Reviews & ratings
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Reviews for Norvasc (Amlodipine)
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435 reviews

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Side effects
  • Swelling due to excess fluid 10%
  • Fatigue 2%
  • Nausea 1%
  • Dizziness 1%
More Norvasc side effects »

We haven’t found good data for Bisoprolol side effects.

FDA side effect reports for Bisoprolol »
How it works
Norvasc (Amlodipine) is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Zebeta (Bisoprolol) is a selective beta blocker that works specifically on the heart. It lowers blood pressure by slowing down the heart and making it work less to pump.
Type of medication
Calcium channel blocker
Prescription only
Beta blocker
Prescription only
Available as
  • Pill
  • Pill
Used for (click to learn more)
Risk factors for serious side effects
  • Age 65 years or older
  • History of heart problems
  • Liver disease
  • History of blood vessel disease
  • History of heart failure
  • History of kidney disease
  • Obesity
Detailed Norvasc (Amlodipine) risks & warnings »
  • Diabetes
    • Coronary artery disease
    • Heart failure
    • Major surgery requiring anesthesia
    Detailed Zebeta (Bisoprolol) risks & warnings »
    Pregnancy category
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    No specific alcohol-related info.No specific alcohol-related info.
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    • Norvasc (Amlodipine) can cause varying degrees of swelling in your limbs. The most commonly affected areas are your feet, ankles, legs, or occasionally your arms. Swelling may be worse if you have other conditions that makes it hard for your body to get rid of fluids such as congestive heart failure or kidney disease. If your swelling is caused by Norvasc (Amlodipine), it should improve when you stop taking the medication. If the swelling is bothersome, a different medication may be better for you.
    No specific kidneys and liver-related info.
    No specific sex-related info.No specific sex-related info.
    No specific sleep-related info.No specific sleep-related info.
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    • A first-choice blood pressure treatment for many people.
    • Calcium channel blockers work especially well for African Americans to lower blood pressure.
    • Lowers the risk of heart attack and stroke.
    • Prevents heart-related chest pain (angina) if you take it regularly.
    • Each dose lasts longer than other calcium channel blockers, which keeps blood pressure consistent without big ups and downs.
    • Particularly good at lowering systolic blood pressure (the top number), so it's a good option for older people who can commonly get high blood pressure only in the top number.
    • Good for protecting the heart and lowering blood pressure if you've had a heart attack.
    • Available in a generic version.
    • Also comes in combination with other medications to lower blood pressure.
    Downsides and risks
    • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
    • Women are more likely to have side effects (especially swelling) from Amlodipine than men.
    • Some people might experience flushing with this medication.
    • You can't miss doses. Stopping Amlodipine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
    • If you have severe heart disease, using Amlodipine might increase your risk of chest pain or heart attack during the time right after starting the medication or raising the dosage.
    • Might not be a good choice if you have liver disease.
    • This isn't a first choice medication to lower blood pressure.
    • You can't stop taking it suddenly, or else you're more likely to have a heart attack or other problems with your heart.
    Tips from our pharmacists for people taking the medication
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Interacts with the cholesterol medicine Simvastatin.
    • Can cause ankle or foot swelling.
    • Can cause gum overgrowth. Ask your dentist to check for this side effect.
    • Zebeta (Bisoprolol) can make you feel dizzy the first few days you take it, so be careful driving and quickly standing up until you know how your body reacts to it.
    • Don't stop taking it suddenly without talking to your doctor.
    • If you have diabetes, Zebeta (Bisoprolol) can make it difficult to tell if your blood sugar is low.
    • Can cause headache, fatigue, and make you more likely to get colds or the flu.
    Learn more
    More about NorvascSide effectsReviews & ratingsAlternativesFDA package insert
    More about BisoprololSide effectsReviews & ratingsAlternativesFDA package insert