Compare Norvasc vs. hydrochlorothiazide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Norvasc
(amlodipine)

Microzide
(hydrochlorothiazide )

Lowers blood pressure. Norvasc (Amlodipine) works well to lower blood pressure and prevent chest pain. You can't miss doses, and you might get persistent swelling.Removes water from the body, which lowers blood pressure. Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that's often the first-choice treatment for mild high blood pressure.
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Coupons for Norvasc
Best available price for 30 (5mg) tablets of amlodipine
Best available price for 30 (12.5mg) capsules of hydrochlorothiazide
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.09Norvasc
Reviews for Norvasc
58%
of people (All ages) say Norvasc is worth it
50%
say it works well
15%
say it's a big hassle
443 reviews
Have you used Norvasc (amlodipine)?
Worth itNot sureNot worth it
Reviews for hydrochlorothiazide
47%
+11% better vs. Norvasc
31%
+19% better vs. Norvasc
16%
+1% better vs. Norvasc
139 reviews
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it
Side effects
Norvaschydrochlorothiazide
  • Swelling due to excess fluid 2%
  • Dizziness 1%
  • Heart pounding or racing sensation 5%
  • Flushing 3%
  • Fatigue 2%
  • Nausea 1%
  • Abdominal pain 2%
  • Drowsiness 2%
More Norvasc side effects »

The hydrochlorothiazide FDA package insert doesn’t have numbers about how common side effects are.

More about hydrochlorothiazide side effects »
How it works
Norvaschydrochlorothiazide
Norvasc (Amlodipine) is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Microzide (hydrochlorothiazide (HCTZ)) is a thiazide diuretic (water pill) that makes you urinate more. It works in the kidneys to remove extra water and certain electrolytes, while lowering blood pressure and reducing swelling.
Type of medication
Norvaschydrochlorothiazide
Prescription onlyPrescription only
Available as
Norvaschydrochlorothiazide
  • Pill
  • Pill
Used for
Norvaschydrochlorothiazide
Risk factors for serious side effects
Norvaschydrochlorothiazide
  • Age 65 years or older
  • History of heart problems
  • Liver disease
  • History of blood vessel disease
  • History of heart failure
Detailed Norvasc (amlodipine) risks & warnings »
  • Current electrolyte imbalance
  • Lower kidney function
  • Dehydration
  • History of sulfa allergies
  • History of gout
Detailed Microzide (hydrochlorothiazide ) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
Norvaschydrochlorothiazide
  • Interacts with the cholesterol medicine Simvastatin.
No interactions related info.
Kidneys and liver
Norvaschydrochlorothiazide
  • Might not be a good choice if you have liver disease.
  • Your body uses your liver to break down Norvasc (Amlodipine) and remove it from your blood. If you have liver disease you may not be able to remove Norvasc (Amlodipine) as quickly from your blood as someone with a healthy liver. You should increase the dose of Norvasc (Amlodipine) slowly and watch closely for how it is working in your body. Increasing the dose slowly will lower your chances of having side effects.
  • Requires routine blood tests to check kidney function.
Pain
Norvaschydrochlorothiazide
  • Worsening heart pain or increased risk of heart attack is possible when you first start taking Norvasc (Amlodipine). This can also happen after you increase the dose of Norvasc (Amlodipine). Notify your doctor immediately if you experience any heart pain, radiating jaw pain, crushing chest pain, or persistent racing heartbeat.
No pain related info.
Upsides and benefits
Norvaschydrochlorothiazide
  • A first-choice blood pressure treatment for many people.
  • Calcium channel blockers work especially well for African Americans to lower blood pressure.
  • Lowers the risk of heart attack and stroke.
  • Prevents heart-related chest pain (angina) if you take it regularly.
  • Each dose lasts longer than other calcium channel blockers, which keeps blood pressure consistent without big ups and downs.
  • Particularly good at lowering systolic blood pressure (the top number), so it's a good option for older people who can commonly get high blood pressure only in the top number.
  • Does a good job getting rid of extra fluids in your body by making you urinate more.
  • A first-choice blood pressure treatment. Works especially well for people of African descent.
  • Lowers the risk of heart attack and stroke.
  • Good option if you have high blood pressure and heart failure.
  • Most people have very few side effects from Microzide (hydrochlorothiazide (HCTZ)).
  • Can be good for patients with osteoporosis since it raises the body's level of calcium.
Downsides and risks
Norvaschydrochlorothiazide
  • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
  • Women are more likely to have side effects (especially swelling) from Amlodipine than men.
  • Some people might experience flushing with this medication.
  • You can't miss doses. Stopping Amlodipine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • If you have severe heart disease, using Amlodipine might increase your risk of chest pain or heart attack during the time right after starting the medication or raising the dosage.
  • Might not be a good choice if you have liver disease.
  • Makes you urinate more often.
  • Microzide (hydrochlorothiazide (HCTZ)) doesn't work well in people with severe kidney problems.
  • It can increase the risk of gout attacks in people with poor kidney function or a history of gout.
  • People with a sulfa allergy may be allergic to Microzide (hydrochlorothiazide (HCTZ)).
Tips from our pharmacists for people taking the medication
Norvaschydrochlorothiazide
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Interacts with the cholesterol medicine Simvastatin.
  • Can cause ankle or foot swelling.
  • Can cause gum overgrowth. Ask your dentist to check for this side effect.
  • Microzide (hydrochlorothiazide (HCTZ)) starts working in about 2 hours.
  • It makes you urinate more often, so don't take it at bedtime.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any tiredness or muscle weakness that doesn't go away.
  • Requires routine blood tests to check kidney function.
Learn more
More about NorvascSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Norvasc (amlodipine)?
Worth itNot sureNot worth it
More about hydrochlorothiazideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Microzide (hydrochlorothiazide )?
Worth itNot sureNot worth it