Compare Norvasc vs. Losartan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Norvasc
(Amlodipine)

Cozaar
(Losartan)

Lowers blood pressure. Norvasc (Amlodipine) works well to lower blood pressure and prevent chest pain. You can't miss doses, and you might get persistent swelling.Lowers blood pressure. Cozaar (Losartan) is a good blood pressure-lowering medicine that protects kidney function like an ACE inhibitor, but with fewer side effects.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.089655172413793Norvasc
Reviews for Norvasc (Amlodipine)
59%
of people say Norvasc (Amlodipine) is worth it
50%
say it works well
14%
say it's a big hassle
Reviews for Cozaar (Losartan)
57%
2% vs. Norvasc (Amlodipine)
47%
3% vs. Norvasc (Amlodipine)
16%
2% vs. Norvasc (Amlodipine)
Side effects
NorvascLosartan
  • Swelling due to excess fluid 10%
  • Fatigue 2%
  • Nausea 1%
  • Dizziness 1%
More Norvasc side effects »
  • Urinary tract infection 6%
  • Diarrhea 5%
  • Low blood sugar 4%
  • Low blood pressure 4%
  • Muscle weakness/fatiguea/fatigue 4%
  • Hyperkalemia 4%
  • Chest pain 4%
  • Low red blood cells 3%
  • Muscular weakness 3%
  • Orthostatic hypotension 3%
More Losartan side effects »
How it works
NorvascLosartan
Norvasc (Amlodipine) is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Cozaar (Losartan) is an angiotensin receptor blocker (ARB). It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs.
Type of medication
NorvascLosartan
Antihypertensive
Calcium channel blocker
Prescription only
Antihypertensive
Angiotensin receptor blocker
Prescription only
Available as
NorvascLosartan
  • Pill
  • Pill
Used for (click to learn more)
NorvascLosartan
Risk factors for serious side effects
NorvascLosartan
  • Age 65 years or older
  • History of heart problems
  • Liver disease
  • History of blood vessel disease
  • History of heart failure
  • History of kidney disease
  • Obesity
Detailed Norvasc (Amlodipine) risks & warnings »
  • Women of childbearing age
  • Concurrent liver disease
  • Current kidney problems
  • Medicine that increase potassium
  • Use of salt substitute
Detailed Cozaar (Losartan) risks & warnings »
Pregnancy category
NorvascLosartan
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
DFDA pregnancy category (Weigh risks vs. benefits)

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
  • Norvasc (Amlodipine) can cause varying degrees of swelling in your limbs. The most commonly affected areas are your feet, ankles, legs, or occasionally your arms. Swelling may be worse if you have other conditions that makes it hard for your body to get rid of fluids such as congestive heart failure or kidney disease. If your swelling is caused by Norvasc (Amlodipine), it should improve when you stop taking the medication. If the swelling is bothersome, a different medication may be better for you.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Requires routine blood tests to check kidney function.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
NorvascLosartan
  • Calcium channel blockers work especially well for African Americans to lower blood pressure.
  • Prevents heart-related chest pain (angina) if you take it regularly.
  • Each dose lasts longer than other calcium channel blockers, which keeps blood pressure consistent without big ups and downs.
  • Particularly good at lowering systolic blood pressure (the top number), so it's a good option for older people who can commonly get high blood pressure only in the top number.
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
  • Similar to ACE inhibitors (like Lisinopril), with fewer side effects like cough and swelling.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
  • A first-choice blood pressure treatment for many people.
  • Lowers the risk of heart attack and stroke.
Downsides and risks
NorvascLosartan
  • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
  • Women are more likely to have side effects (especially swelling) from Amlodipine than men.
  • Some people might experience flushing with this medication.
  • You can't miss doses. Stopping Amlodipine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • If you have severe heart disease, using Amlodipine might increase your risk of chest pain or heart attack during the time right after starting the medication or raising the dosage.
  • Might not be a good choice if you have liver disease.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
Tips from our pharmacists for people taking the medication
NorvascLosartan
  • Interacts with the cholesterol medicine Simvastatin.
  • Can cause ankle or foot swelling.
  • Can cause gum overgrowth. Ask your dentist to check for this side effect.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Tell your doctor about any dizziness, fatigue, cough, or throat irritation that doesn't go away.
  • Requires routine blood tests to check kidney function.
  • Don't take it if you're pregnant.
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
Learn more
More about NorvascSide effectsReviews & ratingsAlternativesFDA package insert
More about LosartanSide effectsReviews & ratingsAlternativesFDA package insert