Compare Norvasc vs. Prazosin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Norvasc
(amlodipine)

Minipress
(prazosin)

Lowers blood pressure. Norvasc (Amlodipine) works well to lower blood pressure and prevent chest pain. You can't miss doses, and you might get persistent swelling.Lowers blood pressure and makes it easier to urinate. Prazosin is used mostly to make urination easier for men with an enlarged prostate, but it can cause dizziness.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.09Norvasc
Reviews for Norvasc
58%
of people (All ages) say Norvasc is worth it
50%
say it works well
15%
say it's a big hassle
443 reviews
Have you used Norvasc (amlodipine)?
Worth itNot sureNot worth it
Reviews for Prazosin
46%
+12% better vs. Norvasc
29%
+21% better vs. Norvasc
15%
Same vs. Norvasc
Have you used Minipress (prazosin)?
Worth itNot sureNot worth it
Side effects
NorvascPrazosin
  • Edema 2%
  • Dizziness 1%
  • Palpitation 5%
  • Flushing 3%
  • Fatigue 2%
  • Nausea 1%
  • Abdominal pain 2%
  • Palpitations 3%
  • Somnolence 2%
More Norvasc side effects »
  • Dizziness 10%
  • Headache 8%
  • Drowsiness 8%
  • Lack of energy 7%
  • Weakness 7%
  • Palpitations 5%
  • Nausea 5%
More Prazosin side effects »
How it works
NorvascPrazosin
Norvasc (Amlodipine) is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Prazosin is a selective alpha blocker. It lowers blood pressure by relaxing blood vessels. It also relaxes the urethra and prostate, which makes it easier to urinate.
Type of medication
NorvascPrazosin
Prescription onlyPrescription only
Available as
NorvascPrazosin
  • Pill
  • Pill
Used for
NorvascPrazosin
Risk factors for serious side effects
NorvascPrazosin
  • Age 65 years or older
  • History of heart problems
  • Liver disease
  • History of blood vessel disease
  • History of heart failure
Detailed Norvasc (amlodipine) risks & warnings »
  • Age 65 years or older
Detailed Minipress (prazosin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
NorvascPrazosin
  • Interacts with the cholesterol medicine Simvastatin.
No interactions related info.
Food
NorvascPrazosin
No food related info.
  • Take with food or at bedtime to avoid side effects.
Kidneys and liver
NorvascPrazosin
  • Your body uses your liver to break down Norvasc (Amlodipine) and remove it from your blood. If you have liver disease you may not be able to remove Norvasc (Amlodipine) as quickly from your blood as someone with a healthy liver. You should increase the dose of Norvasc (Amlodipine) slowly and watch closely for how it is working in your body. Increasing the dose slowly will lower your chances of having side effects.
  • Might not be a good choice if you have liver disease.
No kidneys and liver related info.
Pain
NorvascPrazosin
  • Worsening heart pain or increased risk of heart attack is possible when you first start taking Norvasc (Amlodipine). This can also happen after you increase the dose of Norvasc (Amlodipine). Notify your doctor immediately if you experience any heart pain, radiating jaw pain, crushing chest pain, or persistent racing heartbeat.
No pain related info.
Sleep
NorvascPrazosin
No sleep related info.
  • Can cause drowsiness, headache, dizziness, and nausea.
Upsides and benefits
NorvascPrazosin
  • A first-choice blood pressure treatment for many people.
  • Calcium channel blockers work especially well for African Americans to lower blood pressure.
  • Lowers the risk of heart attack and stroke.
  • Prevents heart-related chest pain (angina) if you take it regularly.
  • Each dose lasts longer than other calcium channel blockers, which keeps blood pressure consistent without big ups and downs.
  • Particularly good at lowering systolic blood pressure (the top number), so it's a good option for older people who can commonly get high blood pressure only in the top number.
  • Can be added to other blood pressure-lowering medicines if you need additional blood pressure control.
  • Makes urination easier in men with an enlarged prostate.
  • Helps people with PTSD get better sleep with fewer, less-intense nightmares.
Downsides and risks
NorvascPrazosin
  • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
  • Women are more likely to have side effects (especially swelling) from Amlodipine than men.
  • Some people might experience flushing with this medication.
  • You can't miss doses. Stopping Amlodipine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • If you have severe heart disease, using Amlodipine might increase your risk of chest pain or heart attack during the time right after starting the medication or raising the dosage.
  • Might not be a good choice if you have liver disease.
  • Not the best medicine to lower blood pressure by itself.
  • Likely to cause orthostatic hypotension. This means dizziness when you change positions (like standing up) because your blood pressure doesn't adjust quickly enough.
  • Not preferred for people 65 years or older.
Tips from our pharmacists for people taking the medication
NorvascPrazosin
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Interacts with the cholesterol medicine Simvastatin.
  • Can cause ankle or foot swelling.
  • Can cause gum overgrowth. Ask your dentist to check for this side effect.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Can cause drowsiness, headache, dizziness, and nausea.
  • Take with food or at bedtime to avoid side effects.
  • If side effects don't go away, talk to your doctor about alternatives.
  • Recheck your blood pressure 1 week after starting this medicine.
Learn more
More about NorvascSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Norvasc (amlodipine)?
Worth itNot sureNot worth it
More about PrazosinSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Minipress (prazosin)?
Worth itNot sureNot worth it