Compare Norvasc vs. Toprol XL

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Norvasc
(Amlodipine)

Toprol XL
(metoprolol succinate)

Lowers blood pressure. Norvasc (Amlodipine) works well to lower blood pressure and prevent chest pain. You can't miss doses, and you might get persistent swelling.Lowers blood pressure and controls heart rate. Toprol XL (metoprolol succinate) is good for controlling chest pain, treating heart failure, and heart attack. It has the added benefit of being taken once a day.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.09Norvasc
Reviews for Norvasc
58%
of people (All ages) say Norvasc is worth it
50%
say it works well
15%
say it's a big hassle
443 reviews
Have you used Norvasc (Amlodipine)?
Worth itNot sureNot worth it
Reviews for Toprol XL
60%
-2% worse vs. Norvasc
54%
-4% worse vs. Norvasc
13%
-2% worse vs. Norvasc
164 reviews
Have you used Toprol XL (metoprolol succinate)?
Worth itNot sureNot worth it
Side effects
NorvascToprol XL
  • Edema 2%
  • Dizziness 1%
  • Flushing 3%
  • Palpitation 5%
  • Abdominal pain 2%
  • Nausea 1%
  • Fatigue 2%
  • Somnolence 2%
  • Palpitations 3%
More Norvasc side effects »
  • Shortness of breath 3%
  • Slower heartbeat 3%
  • Depression 5%
  • Skin rash and itching 5%
  • Diarrhea 5%
  • Tiredness 10%
  • Dizziness 10%
  • Dizziness/balance problems 1%
More Toprol XL side effects »
How it works
NorvascToprol XL
Norvasc (Amlodipine) is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Toprol XL (metoprolol succinate) is a beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.
Type of medication
NorvascToprol XL
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
NorvascToprol XL
  • Pill
  • Extended release
Used for
NorvascToprol XL
Risk factors for serious side effects
NorvascToprol XL
  • Age 65 years or older
  • History of heart problems
  • Liver disease
  • History of blood vessel disease
  • History of heart failure
Detailed Norvasc (Amlodipine) risks & warnings »
  • Sudden discontinuation of medicine
  • Coronary artery disease
  • Diabetes
  • Hyperthyroidsim
  • Heart failure
Detailed Toprol XL (metoprolol succinate) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
NorvascToprol XL
  • Interacts with the cholesterol medicine Simvastatin.
No interactions related info.
Kidneys and liver
NorvascToprol XL
  • Your body uses your liver to break down Norvasc (Amlodipine) and remove it from your blood. If you have liver disease you may not be able to remove Norvasc (Amlodipine) as quickly from your blood as someone with a healthy liver. You should increase the dose of Norvasc (Amlodipine) slowly and watch closely for how it is working in your body. Increasing the dose slowly will lower your chances of having side effects.
  • Might not be a good choice if you have liver disease.
No kidneys and liver related info.
Pain
NorvascToprol XL
  • Worsening heart pain or increased risk of heart attack is possible when you first start taking Norvasc (Amlodipine). This can also happen after you increase the dose of Norvasc (Amlodipine). Notify your doctor immediately if you experience any heart pain, radiating jaw pain, crushing chest pain, or persistent racing heartbeat.
No pain related info.
Upsides and benefits
NorvascToprol XL
  • A first-choice blood pressure treatment for many people.
  • Calcium channel blockers work especially well for African Americans to lower blood pressure.
  • Lowers the risk of heart attack and stroke.
  • Prevents heart-related chest pain (angina) if you take it regularly.
  • Each dose lasts longer than other calcium channel blockers, which keeps blood pressure consistent without big ups and downs.
  • Particularly good at lowering systolic blood pressure (the top number), so it's a good option for older people who can commonly get high blood pressure only in the top number.
  • A first-choice treatment to prevent chest pain (angina). It makes attacks less frequent and helps you be more active without having chest pain.
  • Toprol XL (metoprolol succinate) is a first-choice treatment for heart failure since it may prevent long-term heart damage.
  • It's also a first-choice for heart attack treatment since it lowers the risk of death during and after a heart attack.
  • Toprol XL (metoprolol succinate) is the extended release version of metoprolol tartrate and only needs to be taken once a day.
  • It's available as a generic and is relatively cheap.
Downsides and risks
NorvascToprol XL
  • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
  • Women are more likely to have side effects (especially swelling) from Amlodipine than men.
  • Some people might experience flushing with this medication.
  • You can't miss doses. Stopping Amlodipine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
  • If you have severe heart disease, using Amlodipine might increase your risk of chest pain or heart attack during the time right after starting the medication or raising the dosage.
  • Might not be a good choice if you have liver disease.
  • Taking a beta blocker can make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some this may not go away.
  • It's not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease.
  • Toprol XL (metoprolol succinate) can hide symptoms of low blood sugar if you have diabetes.
  • You can't miss doses. Stopping Toprol XL (metoprolol succinate) suddenly can cause your blood pressure to go up quickly, which increases your risk of heart attack and stroke.
Tips from our pharmacists for people taking the medication
NorvascToprol XL
  • Can cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
  • Interacts with the cholesterol medicine Simvastatin.
  • Can cause ankle or foot swelling.
  • Can cause gum overgrowth. Ask your dentist to check for this side effect.
  • Toprol XL (metoprolol succinate) cause dizziness in the first few days.
  • Check your blood pressure 1 week after starting this medicine and let your doctor know if it hasn't improved.
  • It can make you feel tired or give you headaches.
  • Can hide symptoms of low blood sugar, so be careful taking this if you have diabetes.
  • Don't stop taking this medicine suddenly.
  • This is the extended-release version, but it also comes in an immediate-release form, metoprolol tartrate.
Learn more
More about NorvascSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Norvasc (Amlodipine)?
Worth itNot sureNot worth it
More about Toprol XLSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Toprol XL (metoprolol succinate)?
Worth itNot sureNot worth it