Compare Norvasc vs. Toprol XL

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Norvasc
(Amlodipine)

Toprol Xl
(Metoprolol Succinate)

Lowers blood pressure. Norvasc (Amlodipine) works well to lower blood pressure and prevent chest pain. You can't miss doses, and you might get persistent swelling.Lowers blood pressure and controls heart rate. Toprol Xl (Metoprolol Succinate) is good for controlling chest pain and treating heart failure and heart attack. You can't miss doses.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.09Norvasc
Reviews for Norvasc (Amlodipine)
58%
of people (All ages) say Norvasc (Amlodipine) is worth it
50%
say it works well
15%
say it's a big hassle
443 reviews
Have you used Norvasc (Amlodipine)?
Worth itNot sureNot worth it
Reviews for Toprol Xl (Metoprolol Succinate)
60%
+2% better vs. Norvasc (Amlodipine)
54%
+4% better vs. Norvasc (Amlodipine)
13%
+2% better vs. Norvasc (Amlodipine)
164 reviews
Have you used Toprol Xl (Metoprolol Succinate)?
Worth itNot sureNot worth it
Side effects
NorvascToprol XL
  • Swelling due to excess fluid 2%
  • Dizziness 1%
  • Heart pounding or racing sensation 5%
  • Flushing 3%
  • Fatigue 2%
  • Nausea 1%
  • Abdominal pain 2%
  • Drowsiness 2%
More Norvasc side effects »
  • Tiredness 10%
  • Dizziness 10%
  • Low mood disorder 5%
  • Diarrhea 5%
  • Rash or pruritus 5%
  • Shortness of breath 3%
  • Abnormally slow heartbeat 3%
  • Low blood pressure 4%
  • Heart block 3%
More Toprol XL side effects »
How it works
NorvascToprol XL
Norvasc (Amlodipine) is a calcium channel blocker. It lowers blood pressure by slowing your heart rate and relaxing your blood vessels. Your heart gets more oxygen and doesn't have to work as hard to pump, which can relieve chest pain.Toprol Xl (Metoprolol Succinate) is a beta blocker. It lowers blood pressure by slowing heart rate, relaxing blood vessels, and lowering the body's fight-or-flight response.
Type of medication
NorvascToprol XL
Prescription only
Prescription only
Available as
NorvascToprol XL
  • Pill
  • Pill
  • Extended release
Used for
NorvascToprol XL
Risk factors for serious side effects
NorvascToprol XL
  • Age 65 years or older
  • History of heart problems
  • Liver disease
  • History of blood vessel disease
  • History of heart failure
  • History of kidney disease
  • Obesity
Detailed Norvasc (Amlodipine) risks & warnings »
  • Diabetes
    • Coronary artery disease
    • Heart failure
    • Major surgery requiring anesthesia
    • History of asthma
    Detailed Toprol Xl (Metoprolol Succinate) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Interactions
    NorvascToprol XL
    • Interacts with the cholesterol medicine Simvastatin.
    No interactions related info.
    Kidneys and liver
    NorvascToprol XL
    • Might not be a good choice if you have liver disease.
    • Your body uses your liver to break down Norvasc (Amlodipine) and remove it from your blood. If you have liver disease you may not be able to remove Norvasc (Amlodipine) as quickly from your blood as someone with a healthy liver. You should increase the dose of Norvasc (Amlodipine) slowly and watch closely for how it is working in your body. Increasing the dose slowly will lower your chances of having side effects.
    No kidneys and liver related info.
    Pain
    NorvascToprol XL
    • Worsening heart pain or increased risk of heart attack is possible when you first start taking Norvasc (Amlodipine). This can also happen after you increase the dose of Norvasc (Amlodipine). Notify your doctor immediately if you experience any heart pain, radiating jaw pain, crushing chest pain, or persistent racing heartbeat.
    No pain related info.
    Upsides and benefits
    NorvascToprol XL
    • A first-choice blood pressure treatment for many people.
    • Calcium channel blockers work especially well for African Americans to lower blood pressure.
    • Lowers the risk of heart attack and stroke.
    • Prevents heart-related chest pain (angina) if you take it regularly.
    • Each dose lasts longer than other calcium channel blockers, which keeps blood pressure consistent without big ups and downs.
    • Particularly good at lowering systolic blood pressure (the top number), so it's a good option for older people who can commonly get high blood pressure only in the top number.
    • A first-choice treatment to prevent chest pain (angina). Makes pain attacks less frequent and makes it easier to be active without having chest pain.
    • A first-choice treatment for heart failure. May prevent long-term heart damage.
    • A first-choice treatment for heart attack. Lowers the risk of death during and after a heart attack.
    • Toprol XL is the extended release version of Lopressor.
    Downsides and risks
    NorvascToprol XL
    • Calcium channel blockers can cause swelling in your limbs. If this happens for you, it probably won't get better over time, so talk to your doctor about alternatives if it bothers you.
    • Women are more likely to have side effects (especially swelling) from Amlodipine than men.
    • Some people might experience flushing with this medication.
    • You can't miss doses. Stopping Amlodipine suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
    • If you have severe heart disease, using Amlodipine might increase your risk of chest pain or heart attack during the time right after starting the medication or raising the dosage.
    • Might not be a good choice if you have liver disease.
    • Taking a beta blocker might make you feel more tired or out of breath during exercise or normal daily routines. This gets better for most people, but for some might not go away.
    • Not a first-choice treatment for high blood pressure according to the latest guidelines, except if you have heart failure or heart disease.
    • Can hide symptoms of low blood sugar if you're diabetic.
    • You can't miss doses. Stopping Toprol XL suddenly can cause your blood pressure to go up suddenly, which raises the risk of heart attack and stroke.
    Tips from our pharmacists for people taking the medication
    NorvascToprol XL
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Interacts with the cholesterol medicine Simvastatin.
    • Can cause ankle or foot swelling.
    • Can cause gum overgrowth. Ask your dentist to check for this side effect.
    • Can cause dizziness in the first few days.
    • Check your blood pressure 1 week after starting this medicine, and tell your doctor if it hasn't improved.
    • Can cause fatigue and headache.
    • Can hide symptoms of low blood sugar. Be careful if you're diabetic.
    • Don't stop taking this medicine suddenly.
    • Extended release version. Also comes in immediate release called Lopressor (metoprolol tartrate).
    Learn more
    More about NorvascSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Norvasc (Amlodipine)?
    Worth itNot sureNot worth it
    More about Toprol XLSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Toprol Xl (Metoprolol Succinate)?
    Worth itNot sureNot worth it