Compare Novolog vs. Afrezza

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Novolog
(insulin aspart)

Afrezza
(insulin)

Lowers blood sugar. Novolog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Controls mealtime blood sugar. Afrezza (insulin) is effective at controlling blood sugar, but you can't use it if you've had lung problems or smoke.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.77Novolog
Reviews for Novolog
58%
of people (All ages) say Novolog is worth it
46%
say it works well
19%
say it's a big hassle
177 reviews
Have you used Novolog (insulin aspart)?
Worth itNot sureNot worth it

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Have you used Afrezza (insulin)?
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Side effects
NovologAfrezza
  • Decreased muscle reflexes 11%
  • Nail fungal infection 10%
  • Abnormal sense of touch 9%
  • Urinary tract infection 8%
  • Chest pain 5%
  • Headache 5%
  • Skin disorder 5%
  • Abdominal pain 5%
  • Sinus inflammation 5%
  • Injury accidental 11%
More Novolog side effects »
  • Low blood sugar 37%
  • Dry cough 6%
  • Severe low blood sugar 3%
  • Diarrhea 2%
  • Wet cough 1%
  • Fatigue 1%
  • Nausea 2%
  • Cough 28%
More Afrezza side effects »
How it works
NovologAfrezza
Novolog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.Afrezza (insulin) is an insulin that controls your blood sugar by turning the sugars you eat into energy or storing it in your body for future use.
Type of medication
NovologAfrezza
Prescription onlyPrescription only
Available as
NovologAfrezza
  • Injection
  • Inhalation powder
Used for
NovologAfrezza
Risk factors for serious side effects
NovologAfrezza
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
Detailed Novolog (insulin aspart) risks & warnings »
  • Changes in diet and exercise
  • Drinking alcohol
  • Taking other medications for diabetes
  • Over age 65
  • Liver or kidney problems
Detailed Afrezza (insulin) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
NovologAfrezza
No alcohol related info.
  • Avoid drinking alcohol or using over-the-counter medications that contain alcohol while on Afrezza (insulin).
Food
NovologAfrezza
  • Short-acting insulin good for blood sugar control around meal times.
  • Novolog is a fast-acting insulin that provides sugar control after meals.
  • You should inhale Afrezza (insulin) at the beginning of a meal.
  • Afrezza (insulin) is as effective as other mealtime insulin products.
Kidneys and liver
NovologAfrezza
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
No kidneys and liver related info.
Weight
NovologAfrezza
  • Can cause weight gain and low blood sugar.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
No weight related info.
Upsides and benefits
NovologAfrezza
  • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
  • Novolog is a fast-acting insulin that provides sugar control after meals.
  • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
  • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
  • Afrezza (insulin) is as effective as other mealtime insulin products.
  • Starts working faster and stays in your body for a shorter time than other mealtime insulin products, so you're less likely to have severely low blood sugar.
  • If you don't like needles, Afrezza (insulin) is a good alternative since you inhale it.
  • Safe to use in people 65 or older.
  • Talk to your doctor or pharmacist about ways to lower your copay, such as coupons.
Downsides and risks
NovologAfrezza
  • You have to take insulin by injection.
  • You have to check your blood sugar multiple times every day, usually before each meal.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
  • Not recommended if you're a smoker or if you've smoked in the last 6 months.
  • Afrezza (insulin) only comes in 3 different strengths, so it can be inconvenient if you need a lot of insulin.
  • Not recommended in children under 18.
  • If you're pregnant, you'll need to talk to your doctor before you start Afrezza (insulin).
  • There is no generic available, and may not be covered right away by Medicare or other insurances.
Tips from our pharmacists for people taking the medication
NovologAfrezza
  • Short-acting insulin good for blood sugar control around meal times.
  • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
  • Can cause weight gain and low blood sugar.
  • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
  • Always have a good source of sugar nearby for low blood sugar episodes.
  • Make sure you understand how to give yourself the injections.
  • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
  • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
  • Check your blood sugar levels every day.
  • Take Afrezza (insulin) exactly as your doctor or pharmacist tells you, otherwise you might not get the full dose of the medicine.
  • Keep Afrezza (insulin) in the fridge until you're ready to use it. The Afrezza (insulin) cartridges and inhaler should be left at room temperature for 10 minutes before you use it.
  • You should inhale Afrezza (insulin) at the beginning of a meal.
  • Avoid drinking alcohol or using over-the-counter medications that contain alcohol while on Afrezza (insulin).
  • Avoid driving or operating heavy machinery until you know how Afrezza (insulin) can affect you.
  • If you're using a long-acting insulin, you need to keep using it with Afrezza (insulin).
Learn more
More about NovologSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Novolog (insulin aspart)?
Worth itNot sureNot worth it
More about AfrezzaSide effectsFDA package insert
Have you used Afrezza (insulin)?
Worth itNot sureNot worth it