Compare Novolog vs. Afrezza

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Novolog (Insulin Aspart)

Prescription only

Afrezza (insulin)

Prescription only
Lowers blood sugar.

Novolog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.

3.5/ 5 average rating with 177 reviewsforNovolog
Controls mealtime blood sugar.

Afrezza (insulin) is effective at controlling blood sugar, but you can't use it if you've had lung problems or smoke.

Upsides
  • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
  • Novolog is a fast-acting insulin that provides sugar control after meals.
  • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
  • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
  • Afrezza (insulin) is as effective as other mealtime insulin products.
  • Starts working faster and stays in your body for a shorter time than other mealtime insulin products, so you're less likely to have severely low blood sugar.
  • If you don't like needles, Afrezza (insulin) is a good alternative since you inhale it.
  • Safe to use in people 65 or older.
  • Talk to your doctor or pharmacist about ways to lower your copay, such as coupons.
Downsides
  • You have to take insulin by injection.
  • You have to check your blood sugar multiple times every day, usually before each meal.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
  • Not recommended if you're a smoker or if you've smoked in the last 6 months.
  • Afrezza (insulin) only comes in 3 different strengths, so it can be inconvenient if you need a lot of insulin.
  • Not recommended in children under 18.
  • If you're pregnant, you'll need to talk to your doctor before you start Afrezza (insulin).
  • There is no generic available, and may not be covered right away by Medicare or other insurances.
Used for
Dosage forms
  • Injection
  • Inhalation powder
Price
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Reviews
177 reviews so far
58%
saidit'sworth it
46%
saiditworked well
19%
saidit'sa big hassle

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Side effects
The Novolog (Insulin Aspart) FDA package insert doesn’t have numbers about how common side effects are.
6possible side effects
  • Cough
    28%
  • Throat pain or irritation
    6%
  • Headache
    5%
  • Worsening lung function test
    3%
  • Airway inflammation
    3%
  • Urinary tract infection
    2%
See more detailed side effects
Risks and risk factors
  • Life-threatening low blood sugar (Hypoglycemia)
    • Insulin dose too high
    • Use of other blood sugar lowering medicines
    • Poor injection techniques
    • Unstable kidney functions
    • Unstable liver functions
  • Complications due to low potassium
    • Use of other medicine that lowers potassium
    • Current electrolyte imbalance
  • Severe allergic reactions
See more detailed risks and warnings
  • Low blood sugar
    • Changes in diet and exercise
    • Drinking alcohol
    • Taking other medications for diabetes
    • Over age 65
    • Liver or kidney problems
  • Breathing problems
    • Asthma
    • Chronic Obstructive Pulmonary Disease (COPD)
    • Other long term lung problems
  • Low blood potassium levels
    • Taking laxatives
    • Taking medications that increase urination
  • Worsening lung function
    • Smoking
    • Second-hand smoke
    • Indoor and outdoor pollution
    • Work-related fume and chemical exposure
  • Fluid buildup
    • Taking Avandia or Actos
  • Too much acid in the blood
    • Type 1 diabetes
    • Long periods of fasting
    • Alchohol abuse
    • History of pancreatitis
See more detailed risks and warnings