Compare Novolog vs. Apidra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Novolog (Insulin Aspart)

Prescription only
Lowers blood sugar.

Novolog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.

3.5/ 5 average rating with 177 reviewsforNovolog
Controls blood sugar.

Apidra (insulin glulisine) is an insulin that controls blood sugar during your meals, but you'll still have to follow your doctor's diet and exercise plan.

Upsides
  • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
  • Novolog is a fast-acting insulin that provides sugar control after meals.
  • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
  • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
  • Apidra (insulin glulisine) starts working in as soon as 15 minutes.
  • Programs are available to lower your copay. Talk to your doctor or pharmacist.
  • Can be used in people over 65 and children 4 years of age and older.
Downsides
  • You have to take insulin by injection.
  • You have to check your blood sugar multiple times every day, usually before each meal.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
  • Your doctor might have to check your kidneys and liver regularly if you've had kidney or liver problems in the past.
  • Since Apidra (insulin glulisine) is an injectable, it might not be a good treatment option for people who are afraid of needles.
  • Only available as a brand name, so Apidra (insulin glulisine) can be expensive.
Used for
Dosage forms
  • Injection
  • Injection
Price
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Reviews
177 reviews so far
58%
saidit'sworth it
46%
saiditworked well
19%
saidit'sa big hassle

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Side effects
The Novolog (Insulin Aspart) FDA package insert doesn’t have numbers about how common side effects are.
1possible side effects
  • Common cold
    11%
See more detailed side effects
Risks and risk factors
  • Life-threatening low blood sugar (Hypoglycemia)
    • Insulin dose too high
    • Use of other blood sugar lowering medicines
    • Poor injection techniques
    • Unstable kidney functions
    • Unstable liver functions
  • Complications due to low potassium
    • Use of other medicine that lowers potassium
    • Current electrolyte imbalance
  • Severe allergic reactions
See more detailed risks and warnings
  • Sharing of pen and needles
  • Low blood sugar
    • Changes in diet and exercise
    • Drinking alcohol
    • Taking other medications for diabetes
    • Over age 65
    • Liver or kidney problems
  • Severe allergic reactions
  • Low blood potassium levels
    • Taking laxatives
    • Taking medications that increase urination
  • Mixing of insulins
  • Fluid buildup
    • Taking Avandia or Actos
See more detailed risks and warnings