Compare Novolog vs. Glucotrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Novolog
(Insulin Aspart)

Glucotrol
(Glipizide)

Lowers blood sugar. Novolog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Glucotrol (Glipizide) is a very effective oral blood sugar-lowering medicine. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.758620689655173Novolog
Reviews for Novolog (Insulin Aspart)
58%
of people (All ages) say Novolog (Insulin Aspart) is worth it
46%
say it works well
18%
say it's a big hassle
174 reviews
Have you used Novolog (Insulin Aspart)?
Worth itNot sureNot worth it
Reviews for Glucotrol (Glipizide)
50%
8% vs. Novolog (Insulin Aspart)
32%
14% vs. Novolog (Insulin Aspart)
19%
1% vs. Novolog (Insulin Aspart)
330 reviews
Have you used Glucotrol (Glipizide)?
Worth itNot sureNot worth it
Side effects
NovologGlucotrol

The Novolog FDA package insert doesn’t have numbers about how common side effects are.

More about Novolog side effects »
  • Passing gas 2%
  • Dizziness 1%
  • Nervousness 1%
More Glucotrol side effects »
How it works
NovologGlucotrol
Novolog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.Glucotrol (Glipizide) is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.
Type of medication
NovologGlucotrol
Anti-diabetic
Insulin
Prescription only
Anti-diabetic
Sulfonylurea
Prescription only
Available as
NovologGlucotrol
  • Injection
  • Pill
  • Extended release
Used for (click to learn more)
NovologGlucotrol
Risk factors for serious side effects
NovologGlucotrol
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
  • Use of other medicine that lowers potassium
  • Current electrolyte imbalance
    Detailed Novolog (Insulin Aspart) risks & warnings »
      • Use of other blood sugar lowering medicines
      • Alcohol
      • Intense physical activity
      • History of sulfa allergies
      Detailed Glucotrol (Glipizide) risks & warnings »
      Pregnancy

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Alcohol
      NovologGlucotrol
      No alcohol related info.
      • Avoid drinking alcohol.
      Food
      NovologGlucotrol
      • Novolog is a fast-acting insulin that provides sugar control after meals.
      • Short-acting insulin good for blood sugar control around meal times.
      • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
      • Eat regular, balanced meals to avoid low blood sugar.
      Kidneys and liver
      NovologGlucotrol
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
      Weight
      NovologGlucotrol
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Can cause weight gain and low blood sugar.
      • Can cause mild weight gain (2 to 3 pounds).
      • Can cause weight gain, dizziness, or stomach upset.
      Upsides and benefits
      NovologGlucotrol
      • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
      • Novolog is a fast-acting insulin that provides sugar control after meals.
      • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
      • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      • Oral blood sugar-lowering medicine.
      • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
      • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
      • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
      • One of the least expensive diabetes medicines.
      Downsides and risks
      NovologGlucotrol
      • You have to take insulin by injection.
      • You have to check your blood sugar multiple times every day, usually before each meal.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
      • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
      • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
      • Can cause mild weight gain (2 to 3 pounds).
      • Loses effectiveness over time or as your body stops making insulin.
      • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
      Tips from our pharmacists for people taking the medication
      NovologGlucotrol
      • Short-acting insulin good for blood sugar control around meal times.
      • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
      • Can cause weight gain and low blood sugar.
      • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
      • Always have a good source of sugar nearby for low blood sugar episodes.
      • Make sure you understand how to give yourself the injections.
      • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
      • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
      • Check your blood sugar levels every day.
      • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
      • Can cause weight gain, dizziness, or stomach upset.
      • Avoid drinking alcohol.
      • Eat regular, balanced meals to avoid low blood sugar.
      • Check your blood sugar regularly.
      Learn more
      More about NovologSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Novolog (Insulin Aspart)?
      Worth itNot sureNot worth it
      More about GlucotrolSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Glucotrol (Glipizide)?
      Worth itNot sureNot worth it