Compare Novolog vs. Humalog

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Novolog
(Insulin Aspart)

Humalog
(Insulin Lispro)

Lowers blood sugar. Novolog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Humalog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.77Novolog
Reviews for Novolog
58%
of people (All ages) say Novolog is worth it
46%
say it works well
19%
say it's a big hassle
177 reviews
Have you used Novolog (Insulin Aspart)?
Worth itNot sureNot worth it
Reviews for Humalog
64%
-6% worse vs. Novolog
50%
-4% worse vs. Novolog
16%
-3% worse vs. Novolog
280 reviews
Have you used Humalog (Insulin Lispro)?
Worth itNot sureNot worth it
Side effects
NovologHumalog
  • Chest pain 5%
  • Headache 5%
  • Skin disorder 5%
  • Abdominal pain 5%
  • Sinusitis 5%
  • Urinary tract infection 8%
  • Sensory disturbance 9%
  • Onychomycosis 10%
  • Hyporeflexia 11%
  • Diarrhea 5%
More Novolog side effects »
  • Nausea 6%
  • Surgical procedure 6%
  • Fever 6%
  • Dysmenorrhea 6%
  • Urinary tract infection 6%
  • Abdominal pain 7%
  • Asthenia 7%
  • Bronchitis 7%
  • Myalgia 7%
  • Accidental injury 9%
More Humalog side effects »
How it works
NovologHumalog
Novolog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.Humalog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.
Type of medication
NovologHumalog
Prescription onlyNo lower cost generic availablePrescription onlyNo lower cost generic available
Available as
NovologHumalog
  • Injection
  • Injection
Used for
NovologHumalog
Risk factors for serious side effects
NovologHumalog
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
Detailed Novolog (Insulin Aspart) risks & warnings »
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
Detailed Humalog (Insulin Lispro) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
NovologHumalog
  • Short-acting insulin good for blood sugar control around meal times.
  • Novolog is a fast-acting insulin that provides sugar control after meals.
  • Short-acting insulin good for blood sugar control around meal times.
Kidneys and liver
NovologHumalog
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
Weight
NovologHumalog
  • Can cause weight gain and low blood sugar.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Can cause weight gain and low blood sugar.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
Upsides and benefits
NovologHumalog
  • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
  • Novolog is a fast-acting insulin that provides sugar control after meals.
  • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
  • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
  • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
  • Humalog is a fast-acting insulin that provides sugar control after meals.
  • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
  • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
Downsides and risks
NovologHumalog
  • You have to take insulin by injection.
  • You have to check your blood sugar multiple times every day, usually before each meal.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
  • You have to take insulin by injection.
  • You have to check your blood sugar multiple times every day, usually before each meal.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
Tips from our pharmacists for people taking the medication
NovologHumalog
  • Short-acting insulin good for blood sugar control around meal times.
  • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
  • Can cause weight gain and low blood sugar.
  • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
  • Always have a good source of sugar nearby for low blood sugar episodes.
  • Make sure you understand how to give yourself the injections.
  • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
  • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
  • Check your blood sugar levels every day.
  • Short-acting insulin good for blood sugar control around meal times.
  • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
  • Can cause weight gain and low blood sugar.
  • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
  • Always have a good source of sugar nearby for low blood sugar episodes.
  • Make sure you understand how to give yourself the injections.
  • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
  • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
  • Check your blood sugar levels every day.
Learn more
More about NovologSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Novolog (Insulin Aspart)?
Worth itNot sureNot worth it
More about HumalogSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Humalog (Insulin Lispro)?
Worth itNot sureNot worth it