Compare Novolog vs. Janumet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Novolog
(insulin aspart)

Janumet
(sitagliptin / metformin)

Lowers blood sugar. Novolog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers your blood sugar. Janumet is a combination of two anti-diabetic medicines that work better together, but is available as brand only.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.77Novolog
Reviews for Novolog
58%
of people (All ages) say Novolog is worth it
46%
say it works well
19%
say it's a big hassle
177 reviews
Have you used Novolog (insulin aspart)?
Worth itNot sureNot worth it
Reviews for Janumet
46%
+12% better vs. Novolog
38%
+8% better vs. Novolog
15%
-4% worse vs. Novolog
Have you used Janumet (sitagliptin / metformin)?
Worth itNot sureNot worth it
Side effects
NovologJanumet
  • Hyporeflexia 11%
  • Onychomycosis 10%
  • Sensory disturbance 9%
  • Urinary tract infection 8%
  • Chest pain 5%
  • Headache 5%
  • Skin disorder 5%
  • Abdominal pain 5%
  • Sinusitis 5%
  • Injury accidental 11%
More Novolog side effects »
  • Low blood sugar 15%
  • Diarrhea 4%
  • Upper respiratory tract infection 1%
  • Headache 3%
More Janumet side effects »
How it works
NovologJanumet
Novolog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.Janumet (sitagliptin / metformin) is a combination of two anti-diabetic medicines. Metformin lowers the amount of sugar your body produces, and sitagliptin enhances the release of insulin.
Type of medication
NovologJanumet
Prescription onlyPrescription only
Available as
NovologJanumet
  • Injection
  • Pill
  • Extended release
Used for
NovologJanumet
Risk factors for serious side effects
NovologJanumet
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
Detailed Novolog (insulin aspart) risks & warnings »
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
Detailed Janumet (sitagliptin / metformin) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
NovologJanumet
  • Short-acting insulin good for blood sugar control around meal times.
  • Novolog is a fast-acting insulin that provides sugar control after meals.
  • Take with food to avoid upset stomach with diarrhea, nausea, and vomiting.
Kidneys and liver
NovologJanumet
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
  • Not appropriate for those with poor kidney function.
Weight
NovologJanumet
  • Can cause weight gain and low blood sugar.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
No weight related info.
Upsides and benefits
NovologJanumet
  • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
  • Novolog is a fast-acting insulin that provides sugar control after meals.
  • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
  • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
  • This 2-in-1 combination can lower the number of pills you have to take daily.
  • Lowers A1c (average blood sugar over time) up to 2.5%.
  • Available in extended and immediate release forms to allow better control of your blood sugar.
  • Doesn't increase your appetite unlike other anti-diabetic medicines.
  • Does not cause hypoglycemia or very low blood sugar.
Downsides and risks
NovologJanumet
  • You have to take insulin by injection.
  • You have to check your blood sugar multiple times every day, usually before each meal.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
  • Available as brand name only and may be expensive.
  • Metformin component usually causes upset stomach.
  • Sitagliptin component may increase your risk for throat infections and inflammation of pancreas.
  • Not appropriate for those with poor kidney function.
Tips from our pharmacists for people taking the medication
NovologJanumet
  • Short-acting insulin good for blood sugar control around meal times.
  • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
  • Can cause weight gain and low blood sugar.
  • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
  • Always have a good source of sugar nearby for low blood sugar episodes.
  • Make sure you understand how to give yourself the injections.
  • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
  • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
  • Check your blood sugar levels every day.
  • Take with food to avoid upset stomach with diarrhea, nausea, and vomiting.
  • May cause headaches and cold-like symptoms.
  • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
  • Can be expensive depending on insurance coverage.
  • Check your blood sugar regularly.
Learn more
More about NovologSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Novolog (insulin aspart)?
Worth itNot sureNot worth it
More about JanumetSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Janumet (sitagliptin / metformin)?
Worth itNot sureNot worth it