Compare Novolog vs. Januvia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Novolog
(Insulin Aspart)

Januvia
(sitagliptin)

Lowers blood sugar. Novolog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers your blood sugar. Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.77Novolog
Reviews for Novolog
58%
of people (All ages) say Novolog is worth it
46%
say it works well
19%
say it's a big hassle
177 reviews
Have you used Novolog (Insulin Aspart)?
Worth itNot sureNot worth it
Reviews for Januvia
44%
+14% better vs. Novolog
34%
+12% better vs. Novolog
17%
-2% worse vs. Novolog
143 reviews
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
Side effects
NovologJanuvia
  • Chest pain 5%
  • Headache 5%
  • Skin disorder 5%
  • Abdominal pain 5%
  • Sinusitis 5%
  • Urinary tract infection 8%
  • Sensory disturbance 9%
  • Onychomycosis 10%
  • Hyporeflexia 11%
  • Diarrhea 5%
More Novolog side effects »
  • Diarrhea 1%
  • Common cold 2%
  • Upper respiratory infection 3%
  • Headache 1%
More Januvia side effects »
How it works
NovologJanuvia
Novolog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin.
Type of medication
NovologJanuvia
Prescription onlyNo lower cost generic availablePrescription onlyNo lower cost generic available
Available as
NovologJanuvia
  • Injection
  • Pill
Used for
NovologJanuvia
Risk factors for serious side effects
NovologJanuvia
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
Detailed Novolog (Insulin Aspart) risks & warnings »
  • History of pancreatitis
  • High blood triglyceride levels
  • Gallstones (stones in gallbladder)
  • History of alchoholism
  • Kidney problems
Detailed Januvia (sitagliptin) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
NovologJanuvia
  • Short-acting insulin good for blood sugar control around meal times.
  • Novolog is a fast-acting insulin that provides sugar control after meals.
  • Take once a day in the morning with or without food.
Kidneys and liver
NovologJanuvia
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
  • Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function.
Pain
NovologJanuvia
No pain related info.
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
Weight
NovologJanuvia
  • Can cause weight gain and low blood sugar.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
Upsides and benefits
NovologJanuvia
  • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
  • Novolog is a fast-acting insulin that provides sugar control after meals.
  • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
  • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
  • Oral blood sugar-lowering medicine.
  • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
  • Uses the hormones naturally produced by your body to affect how sugar is processed.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
Downsides and risks
NovologJanuvia
  • You have to take insulin by injection.
  • You have to check your blood sugar multiple times every day, usually before each meal.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
  • Lowers A1c (average blood sugar over time) by less than 1%.
  • Available as brand version only.
  • Some people might get frequent cold-like symptoms.
  • Rare but serious side effects include pancreatitis and severe joint pain.
Tips from our pharmacists for people taking the medication
NovologJanuvia
  • Short-acting insulin good for blood sugar control around meal times.
  • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
  • Can cause weight gain and low blood sugar.
  • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
  • Always have a good source of sugar nearby for low blood sugar episodes.
  • Make sure you understand how to give yourself the injections.
  • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
  • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
  • Check your blood sugar levels every day.
  • Take once a day in the morning with or without food.
  • Can cause headache and cold-like symptoms.
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
  • Tell your doctor right away if you are experiencing severe joint pain.
  • Check your blood sugar regularly to check for low blood sugar.
Learn more
More about NovologSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Novolog (Insulin Aspart)?
Worth itNot sureNot worth it
More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it