Compare Nyquil Cold and Flu vs. Advil PM

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Nyquil Cold And Flu
(Acetaminophen / Dextromethorphan / Doxylamine)

Advil Pm
(Diphenhydramine / Ibuprofen)

Relieves cold and flu symptoms, and helps you sleep. Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.Relieves pain and helps you sleep. Advil Pm (Diphenhydramine / Ibuprofen) works well at relieving pain and also helps you sleep.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.261722080136402Nyquil Cold and Flu
Reviews for Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine)
83%
of people say Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is worth it
42%
say it works well
6%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
Nyquil Cold and FluAdvil PM

We haven’t found good data for Nyquil Cold and Flu side effects.

FDA side effect reports for Nyquil Cold and Flu »

We haven’t found good data for Advil PM side effects.

FDA side effect reports for Advil PM »
How it works
Nyquil Cold and FluAdvil PM
Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.Advil Pm (Diphenhydramine / Ibuprofen) is a combination medicine that treats cold and flu symptoms. Ibuprofen is an NSAID that relieves pain and reduces fever. Diphenhydramine is an antihistamine that treats runny nose and watery eyes and helps you sleep.
Type of medication
Nyquil Cold and FluAdvil PM
Pain reliever
APAP
Cough suppressantAntihistamine
Ethanolamine derivative
Over-the-counter
Antihistamine
1st generation
Pain reliever
NSAID
Over-the-counter
Available as
Nyquil Cold and FluAdvil PM
  • Pill
  • Liquid
  • Pill
Used for (click to learn more)
Nyquil Cold and FluAdvil PM
Risk factors for serious side effects
Nyquil Cold and FluAdvil PM
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • Using other medications that affect serotonin
  • Taking with alcohol
  • Taking with other medicines that make you less alert
  • Age 65 years or older
  • Glaucoma
  • Benign prostatic hypertrophy (BPH)
Detailed Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) risks & warnings »
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking aspirin, NSAIDs, or blood thinners
  • Drinking more than 3 alcoholic beverages a day
  • Women of childbearing age
  • Taking with aspirin
  • Age 65 years or older
  • High blood pressure
  • Heart disease
  • Kidney disease
  • History of falls
  • Age 65 or older
  • Taking other drugs that make you drowsy or dizzy
Detailed Advil Pm (Diphenhydramine / Ibuprofen) risks & warnings »
Pregnancy category
Nyquil Cold and FluAdvil PM
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
  • Avoid using alcohol and other drugs that make you drowsy.
  • Don't take Advil Pm (Diphenhydramine / Ibuprofen) with alcohol or other drugs that make you sleepy.
Food
No specific food-related info.
  • Contains ibuprofen, so take it with food to avoid stomach problems and ulcers.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
  • The antihistamine (doxylamine) will help you sleep.
  • Avoid using alcohol and other drugs that make you drowsy.
  • Isn't habit-forming like some other pain medicines and sleep aids.
  • Diphenhydramine makes you tired, so take Advil Pm (Diphenhydramine / Ibuprofen) before you go to sleep.
  • Diphenhydramine, also known as Benadryl, is an antihistamine in Advil Pm (Diphenhydramine / Ibuprofen) that can make you feel dizzy or drowsy. People who are at a higher risk of falls should avoid using Advil Pm (Diphenhydramine / Ibuprofen).
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
Nyquil Cold and FluAdvil PM
  • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) will help you sleep.
  • Advil Pm (Diphenhydramine / Ibuprofen) works well when you have a cold or the flu, but can also be used for backaches, minor arthritis, and joint pain.
  • Can be used for anyone 12 years or older.
  • Isn't habit-forming like some other pain medicines and sleep aids.
Downsides and risks
Nyquil Cold and FluAdvil PM
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • The pain reliever (ibuprofen) can interact with other medications and make health problems like stomach bleeding and ulcers worse.
  • The antihistamine (diphenhydramine) can make you feel groggy the next morning.
  • Can only take one dose in 24 hours.
  • Can increase the risk of falls, so elderly people shouldn't use it.
Tips from our pharmacists for people taking the medication
Nyquil Cold and FluAdvil PM
  • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
  • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Avoid using alcohol and other drugs that make you drowsy.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Contains ibuprofen, so take it with food to avoid stomach problems and ulcers.
  • Diphenhydramine makes you tired, so take Advil Pm (Diphenhydramine / Ibuprofen) before you go to sleep.
  • Don't take Advil Pm (Diphenhydramine / Ibuprofen) with alcohol or other drugs that make you sleepy.
  • Don't take Advil Pm (Diphenhydramine / Ibuprofen) if you're pregnant.
Learn more
More about Nyquil Cold and FluSide effectsReviews & ratingsAlternativesFDA package insert
More about Advil PMSide effectsReviews & ratingsAlternativesFDA package insert