Compare Nyquil Cold and Flu vs. Tylenol PM

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Nyquil Cold And Flu
(Acetaminophen / Dextromethorphan / Doxylamine)

Tylenol Pm
(Acetaminophen / Diphenhydramine)

Relieves cold and flu symptoms, and helps you sleep. Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.Relieves pain and helps you sleep. Tylenol Pm (Acetaminophen / Diphenhydramine) works well at relieving pain and also helps you sleep.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.261722080136402Nyquil Cold and Flu
Reviews for Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine)
83%
of people say Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is worth it
42%
say it works well
6%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
Nyquil Cold and FluTylenol PM

We haven’t found good data for Nyquil Cold and Flu side effects.

FDA side effect reports for Nyquil Cold and Flu »

We haven’t found good data for Tylenol PM side effects.

FDA side effect reports for Tylenol PM »
How it works
Nyquil Cold and FluTylenol PM
Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.Tylenol Pm (Acetaminophen / Diphenhydramine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Diphenhydramine is an antihistamine that treats runny nose and watery eyes and helps you sleep.
Type of medication
Nyquil Cold and FluTylenol PM
Pain reliever
APAP
Cough suppressantAntihistamine
Ethanolamine derivative
Over-the-counter
Pain reliever
Acetaminophen (APAP)
Antihistamine
1st generation
Over-the-counter
Available as
Nyquil Cold and FluTylenol PM
  • Pill
  • Liquid
  • Pill
Used for (click to learn more)
Nyquil Cold and FluTylenol PM
Risk factors for serious side effects
Nyquil Cold and FluTylenol PM
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • Using other medications that affect serotonin
  • Taking with alcohol
  • Taking with other medicines that make you less alert
  • Age 65 years or older
  • Glaucoma
  • Benign prostatic hypertrophy (BPH)
Detailed Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) risks & warnings »
  • History of falls
  • Age 65 or older
  • Taking other drugs that make you drowsy or dizzy
  • Drinking more than 3 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • Age 65 years or older
  • Glaucoma
  • Benign prostatic hypertrophy (BPH)
Detailed Tylenol Pm (Acetaminophen / Diphenhydramine) risks & warnings »
Pregnancy category
Nyquil Cold and FluTylenol PM
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
  • Avoid using alcohol and other drugs that make you drowsy.
  • Don't take Tylenol Pm (Acetaminophen / Diphenhydramine) with alcohol or other drugs that make you sleepy.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
  • The antihistamine (doxylamine) will help you sleep.
  • Avoid using alcohol and other drugs that make you drowsy.
  • Isn't habit-forming like some other pain medicines and sleep aids.
  • Diphenhydramine makes you tired, so take Tylenol Pm (Acetaminophen / Diphenhydramine) before you go to sleep.
  • Diphenhydramine, also known as Benadryl, is an antihistamine in Tylenol Pm (Acetaminophen / Diphenhydramine) that can make you feel dizzy or drowsy. People who are at a higher risk of falls should avoid using Tylenol Pm (Acetaminophen / Diphenhydramine).
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
Nyquil Cold and FluTylenol PM
  • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) will help you sleep.
  • Tylenol Pm (Acetaminophen / Diphenhydramine) works well when you have a cold or the flu, but can also be used for backaches, minor arthritis, and joint pain.
  • Can be used for anyone 12 years or older.
  • Isn't habit-forming like some other pain medicines and sleep aids.
Downsides and risks
Nyquil Cold and FluTylenol PM
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • The antihistamine (diphenhydramine) can make you feel groggy the next morning.
  • Can increase the risk of falls, so elderly people shouldn't use it.
  • Can only take one dose in 24 hours.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
Tips from our pharmacists for people taking the medication
Nyquil Cold and FluTylenol PM
  • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
  • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
  • Avoid using alcohol and other drugs that make you drowsy.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Diphenhydramine makes you tired, so take Tylenol Pm (Acetaminophen / Diphenhydramine) before you go to sleep.
  • Don't take Tylenol Pm (Acetaminophen / Diphenhydramine) with alcohol or other drugs that make you sleepy.
  • Let your doctor know if your symptoms don't improve in a few days.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
Learn more
More about Nyquil Cold and FluSide effectsReviews & ratingsAlternativesFDA package insert
More about Tylenol PMSide effectsReviews & ratingsAlternativesFDA package insert