Compare Nyquil Cold And Flu vs. Tylenol Sinus

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Nyquil Cold And Flu
(acetaminophen / dextromethorphan / doxylamine)

Tylenol Sinus
(acetaminophen / phenylephrine)

Relieves cold and flu symptoms, and helps you sleep. Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.Relieves pain and congestion. Tylenol Sinus (Acetaminophen / Phenylephrine) is a good combination medicine to relieve pain and congestion. Be careful to not take too much acetaminophen (APAP) each day.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.27Nyquil Cold And Flu
Reviews for Nyquil Cold And Flu (acetaminophen / dextromethorphan / doxylamine)
83%
of people (All ages) say Nyquil Cold And Flu (acetaminophen / dextromethorphan / doxylamine) is worth it
42%
say it works well
7%
say it's a big hassle
1188 reviews
Have you used Nyquil Cold And Flu (acetaminophen / dextromethorphan / doxylamine)?
Worth itNot sureNot worth it
Reviews for Tylenol Sinus (acetaminophen / phenylephrine)
74%
-9% worse vs. Nyquil Cold And Flu (acetaminophen / dextromethorphan / doxylamine)
31%
-11% worse vs. Nyquil Cold And Flu (acetaminophen / dextromethorphan / doxylamine)
5%
+2% better vs. Nyquil Cold And Flu (acetaminophen / dextromethorphan / doxylamine)
1176 reviews
Have you used Tylenol Sinus (acetaminophen / phenylephrine)?
Worth itNot sureNot worth it
Side effects
Nyquil Cold And FluTylenol Sinus

We haven’t found good data for Nyquil Cold And Flu side effects.

FDA side effect reports for Nyquil Cold And Flu »

We haven’t found good data for Tylenol Sinus side effects.

FDA side effect reports for Tylenol Sinus »
How it works
Nyquil Cold And FluTylenol Sinus
Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.Tylenol Sinus (Acetaminophen / Phenylephrine) is a combination medicine that treats cold and allergy symptoms. Acetaminophen relieves pain and reduces fever. Phenylephrine is a decongestant that clears your sinuses.
Type of medication
Nyquil Cold And FluTylenol Sinus
Over-the-counter
Over-the-counter
Available as
Nyquil Cold And FluTylenol Sinus
  • Pill
  • Liquid
  • Pill
Used for
Nyquil Cold And FluTylenol Sinus
Risk factors for serious side effects
Nyquil Cold And FluTylenol Sinus
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • Using other medications that affect serotonin
  • Taking with alcohol
Detailed Nyquil Cold And Flu (acetaminophen / dextromethorphan / doxylamine) risks & warnings »
  • Drinking more than 2 alcoholic beverages a day
  • Taking with other Tylenol-containing medicines
  • History of liver disease
  • History of high blood pressure
  • Taking MAO inhibitors
Detailed Tylenol Sinus (acetaminophen / phenylephrine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
Nyquil Cold And FluTylenol Sinus
  • Avoid using alcohol and other drugs that make you drowsy.
No alcohol related info.
Kidneys and liver
Nyquil Cold And FluTylenol Sinus
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
Pain
Nyquil Cold And FluTylenol Sinus
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
Upsides and benefits
Nyquil Cold And FluTylenol Sinus
  • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
  • The cough medicine (dextromethorphan) works well and has very few side effects.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
  • The antihistamine (doxylamine) will help you sleep.
  • Tylenol Sinus (Acetaminophen / Phenylephrine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have a stuffy nose, a headache, and pain.
  • The decongestant (phenylephrine) has fewer side effects than other decongestants like pseudoephedrine. It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than to other pain medications like aspirin or ibuprofen.
Downsides and risks
Nyquil Cold And FluTylenol Sinus
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
  • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine.
  • You shouldn't use it if you have high blood pressure.
  • To avoid hurting your liver, you need to keep track of the total amount of acetaminophen (APAP) you are taking since it is a very common ingredient in pain and cold/flu combination medicines.
Tips from our pharmacists for people taking the medication
Nyquil Cold And FluTylenol Sinus
  • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
  • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Avoid using alcohol and other drugs that make you drowsy.
  • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
  • Starts working in 30 minutes.
  • Phenylephrine (the decongestant ingredient) can make you restless, so don't take it too close to bedtime.
  • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
  • Follow age-specific dosing instructions on how much to take.
  • Let your doctor know if your symptoms don't improve in a few days.
Learn more
More about Nyquil Cold And FluSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Nyquil Cold And Flu (acetaminophen / dextromethorphan / doxylamine)?
Worth itNot sureNot worth it
More about Tylenol SinusSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tylenol Sinus (acetaminophen / phenylephrine)?
Worth itNot sureNot worth it