Compare Odefsey vs. Truvada

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Odefsey
(emtricitabine / rilpivirine / tenofovir)

Truvada
(emtricitabine / tenofovir)

Treats HIV infection Odefsey (emtricitabine / rilpivirine / tenofovir) is a convenient 3-in-1 medication used to treat HIV infections. It's similar to Complera, but contains a newer HIV drug which has shown to cause less harmful effects on your kidneys and bones.Works with other medicines to treat HIV infection. Truvada (Emtricitabine / Tenofovir) is a popular combination medicine that has two drugs with the same mechanism of action to treat and prevent HIV infection.
Reviews & ratings
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Have you used Odefsey (emtricitabine / rilpivirine / tenofovir)?
Worth itNot sureNot worth it
Reviews for Truvada
100%
-100% worse vs. Odefsey
94%
-94% worse vs. Odefsey
0%
Same vs. Odefsey
Have you used Truvada (emtricitabine / tenofovir)?
Worth itNot sureNot worth it
Side effects
OdefseyTruvada
  • Headache 19%
  • Depression 19%
  • Somnolence 14%
  • Nausea 11%
  • Dizziness 8%
  • Abdominal pain 8%
  • Vomiting 6%
  • Rash 6%
More Odefsey side effects »
  • > 5% bone mineral density loss 7%
  • Headache 1%
  • Syphilis 1%
  • Secondary syphilis 2%
  • Abdominal pain 2%
More Truvada side effects »
How it works
OdefseyTruvada
Odefsey (emtricitabine / rilpivirine / tenofovir) is a combination pill that contains three antiretroviral (ARV) drugs. It treats HIV infections by preventing the virus from attacking your immune cells and multiplying.Truvada (Emtricitabine / Tenofovir) is a combination medication that stops the replication of the human immunodeficiency virus (HIV) within important cells of the body. Emtricitabine and tenofovir both prevent the virus from taking over normal functions of the cell for its own purposes.
Type of medication
OdefseyTruvada
Prescription onlyPrescription only
Available as
OdefseyTruvada
  • Pill
  • Pill
Used for
OdefseyTruvada
Risk factors for serious side effects
OdefseyTruvada
  • Liver disease
  • Women
  • Obesity
  • Hepatitis B Virus infection
  • History of mental health problems
Detailed Odefsey (emtricitabine / rilpivirine / tenofovir) risks & warnings »
  • Infection with chronic hepatitis B and stopping Truvada (Emtricitabine / Tenofovir)
  • Taking high dose anti-inflammatory drugs (NSAIDs)
  • Undiscovered HIV infection
Detailed Truvada (emtricitabine / tenofovir) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Food
OdefseyTruvada
  • Take each dose with a light meal.
No food related info.
Kidneys and liver
OdefseyTruvada
No kidneys and liver related info.
  • Before starting Truvada (Emtricitabine / Tenofovir), your doctor will test you for hepatitis B to make sure you're not infected. People who've stopped Truvada (Emtricitabine / Tenofovir) and had chronic hepatitis B have suffered from liver damage and failure.
  • People on Truvada (Emtricitabine / Tenofovir) have reported kidney damage, which can be made worse if you take high doses of anti-inflammatory drugs called NSAIDs (Motrin/Advil, Aleve, Mobic, Voltaren, etc.). Call your doctor if you develop bone pain, pain in your arms or legs, or pain or weakness in your muscles.
  • Can cause unusual dreams, or kidney or liver damage.
  • Truvada (Emtricitabine / Tenofovir) is removed from the body by the kidneys, so the dose of Truvada (Emtricitabine / Tenofovir) needs to be lowered if you have any kidney problems.
Upsides and benefits
OdefseyTruvada
  • Odefsey (emtricitabine / rilpivirine / tenofovir) combines three medications into one tablet, so it's easy to take.
  • Odefsey (emtricitabine / rilpivirine / tenofovir) is currently the smallest combination HIV tablet available.
  • Odefsey (emtricitabine / rilpivirine / tenofovir) works similar to Complera, but is less likely to cause harmful side effects on your kidneys and bones.
  • Odefsey (emtricitabine / rilpivirine / tenofovir) might be an option for HIV treatment if other HIV drug combinations haven't worked for you.
  • First-line treatment for preventing HIV infection in combination with other HIV medications.
  • Only has to be taken once a day.
  • Truvada (Emtricitabine / Tenofovir) prevents and treats HIV infection.
  • Used for preventing HIV infection in case you've been accidentally exposed or if you're in danger of being exposed.
Downsides and risks
OdefseyTruvada
  • Odefsey (emtricitabine / rilpivirine / tenofovir) has to be taken with a light meal.
  • Cannot be taken with proton pump inhibitors (PPI) like Prilosec or Prevacid. If you need an acid reducer, try taking an antacid like calcium carbonate either 2 hours before or 4 hours after Odefsey (emtricitabine / rilpivirine / tenofovir). Drugs like Pepcid or Zantac (H2RAs) may also be an option, but these should be taken 12 hours before or 4 hours after Odefsey (emtricitabine / rilpivirine / tenofovir).
  • Not recommended for patients who have a significantly high level of viral cells or have a very low level of immune cells.
  • Can cause abnormal heart rhythm.
  • Has to be taken at the same time every day or your body can become resistant to the medication.
  • Can't be taken on its own to treat HIV.
  • Can cause unusual dreams, or kidney or liver damage.
  • Can't be taken with any drugs containing lamivudine since both are so similar to each other.
  • Truvada (Emtricitabine / Tenofovir) is removed from the body by the kidneys, so the dose of Truvada (Emtricitabine / Tenofovir) needs to be lowered if you have any kidney problems.
Tips from our pharmacists for people taking the medication
OdefseyTruvada
  • Odefsey (emtricitabine / rilpivirine / tenofovir) should be taken at the same time everyday.
  • Take each dose with a light meal.
  • Talk to your doctor immediately if you notice yellowing of eyes or skin, dark urine, rash, fever, fatigue, or have difficulty breathing, as these may be signs of liver problems or sensitivity reactions.
  • Since Truvada (Emtricitabine / Tenofovir) is only taken once a day, try taking it at the same time as your other HIV medications.
  • If being used for kids, the dose of Truvada (Emtricitabine / Tenofovir) will continue to change as they grow, so keep in touch with their doctor.
  • Keep an eye out for any new symptoms or side effects you may start to feel while taking Truvada (Emtricitabine / Tenofovir) and report them to your doctor.
  • Practice safe sex while taking Truvada (Emtricitabine / Tenofovir) since the medication will not stop you from passing HIV to other people.
Learn more
More about OdefseySide effectsAlternativesFDA package insert
Have you used Odefsey (emtricitabine / rilpivirine / tenofovir)?
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More about TruvadaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Truvada (emtricitabine / tenofovir)?
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