Compare Ogen Vaginal Cream vs. Estradiol Norethindrone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ogen Vaginal Cream
(Estropipate)

Activella
(Estradiol / Norethindrone)

Relieves vaginal dryness due to menopause. Ogen Vaginal Cream (Estropipate) works well for vaginal problems caused by menopause. It has fewer side effects than estrogen pills, but you might still need to use it every day.Relieves menopause symptoms and lowers your risk of osteoporosis. Activella (Estradiol / Norethindrone) is effective at treating symptoms related to menopause and preventing bone loss. The estrogen/progestin combo is a good options for women with an intact uterus.
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Side effects
Ogen Vaginal CreamEstradiol Norethindrone

The Ogen Vaginal Cream FDA package insert doesn’t have numbers about how common side effects are.

More about Ogen Vaginal Cream side effects »
  • Excessive vaginal bleeding 14%
  • Injury accidental 13%
  • Endometrial thickening 6%
  • Back pain 6%
  • Sinus inflammation 5%
  • Common cold 3%
  • Headache 3%
  • Weight increase 3%
  • "stomach flu" 2%
  • Other events 2%
More Estradiol Norethindrone side effects »
How it works
Ogen Vaginal CreamEstradiol Norethindrone
Ogen Vaginal Cream (Estropipate) replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps rebuild and maintain vaginal tissue, relieving symptoms of vaginal dryness, soreness, irritation, and painful sex.Activella (Estradiol / Norethindrone) contains two hormones that work to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norethindrone (a progestin) protects the uterus from damage.
Type of medication
Ogen Vaginal CreamEstradiol Norethindrone
Hormone replacement
Estrogen derivative
Prescription only
Hormone replacement
Estrogen
Progestin
Prescription only
Available as
Ogen Vaginal CreamEstradiol Norethindrone
  • Vaginal cream, gel, or ointment
  • Pill
Used for (click to learn more)
Ogen Vaginal CreamEstradiol Norethindrone
  • Vaginal dryness and inflammation
  • Hot flashes and night sweats
Risk factors for serious side effects
Ogen Vaginal CreamEstradiol Norethindrone
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
  • Women of childbearing age
Detailed Ogen Vaginal Cream (Estropipate) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Women of childbearing age
  • High levels of triglycerides
  • Family history of ovarian cancer
Detailed Activella (Estradiol / Norethindrone) risks & warnings »
Pregnancy category
Ogen Vaginal CreamEstradiol Norethindrone
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
  • No vaginal sex immediately after using Ogen Vaginal Cream (Estropipate) to prevent your partner from being exposed to the medicine.
  • Ogen Vaginal Cream (Estropipate) relieves vaginal dryness and irritation to make sex more enjoyable.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Ogen Vaginal Cream (Estropipate) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
Ogen Vaginal CreamEstradiol Norethindrone
  • Ogen Vaginal Cream (Estropipate) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Generally works well with few side effects.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Ogen Vaginal Cream (Estropipate) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
  • Activella (Estradiol / Norethindrone) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Good choice for women with intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Mimvey brand is less expensive than other estrogen/progestin combination medicines.
Downsides and risks
Ogen Vaginal CreamEstradiol Norethindrone
  • No vaginal sex immediately after using Ogen Vaginal Cream (Estropipate) to prevent your partner from being exposed to the medicine.
  • The cream can weaken latex (rubber) condoms, cervical caps, and diaphrams. Don't use these within 72 hours after a dose.
  • Inserting the applicator can possibly cause discomfort or infection.
  • If you have your uterus, you have to use Ogen Vaginal Cream (Estropipate) with another hormone called progestin to lower your risk of uterine cancer.
  • More potential side effects since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
Tips from our pharmacists for people taking the medication
Ogen Vaginal CreamEstradiol Norethindrone
  • Apply Ogen Vaginal Cream (Estropipate) directly to your vagina daily.
  • Attach the applicator to the tube and squeeze it to get your dose into the applicator. Insert the applicator deeply into your vagina and press the plunger to release all the medicine.
  • Best used at bedtime to increase effectiveness.
  • Consider wearing a panty liner.
  • Clean the applicator with soap and warm water after each use.
  • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
  • Tell your doctor about any unusual vaginal bleeding.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • Tell your doctor about any unusual vaginal bleeding.
Learn more
More about Ogen Vaginal CreamSide effectsAlternativesFDA package insert
More about Estradiol NorethindroneSide effectsReviews & ratingsAlternativesFDA package insert