Compare Ogen Vaginal Cream vs. Estradiol Norethindrone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ogen Vaginal Cream
(estropipate)

Activella
(estradiol / norethindrone)

Relieves vaginal dryness due to menopause. Ogen Vaginal Cream (Estropipate) works well for vaginal problems caused by menopause. It has fewer side effects than estrogen pills, but you might still need to use it every day.Relieves menopause symptoms and lowers your risk of osteoporosis. Activella (Estradiol / Norethindrone) is effective at treating symptoms related to menopause and preventing bone loss. The estrogen/progestin combo is a good options for women with an intact uterus.
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Coupons for Ogen Vaginal Cream
Best available price for 30 (1.5mg) tablets of estropipate
Best available price for 1 (28 tablets of 0.5mg/0.1mg) package of estradiol / norethindrone
Reviews & ratings
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Reviews for Ogen Vaginal Cream (estropipate)
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of people (All ages) say Ogen Vaginal Cream (estropipate) is worth it
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say it works well
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say it's a big hassle
Have you used Ogen Vaginal Cream (estropipate)?
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Reviews for Activella (estradiol / norethindrone)
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+100% better vs. Ogen Vaginal Cream (estropipate)
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+100% better vs. Ogen Vaginal Cream (estropipate)
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Same vs. Ogen Vaginal Cream (estropipate)
Have you used Activella (estradiol / norethindrone)?
Worth itNot sureNot worth it
Side effects
Ogen Vaginal CreamEstradiol Norethindrone

The Ogen Vaginal Cream FDA package insert doesn’t have numbers about how common side effects are.

More about Ogen Vaginal Cream side effects »
  • Breast pain 24%
  • Ear, nose, or throat infection 18%
  • Headache 16%
  • Sinus inflammation 7%
  • Sleep difficulty 6%
  • Back pain 6%
  • Post-menopausal bleeding 5%
  • Uterine fibroid 5%
  • Infection viral 4%
  • Moniliasis genital 4%
More Estradiol Norethindrone side effects »
How it works
Ogen Vaginal CreamEstradiol Norethindrone
Ogen Vaginal Cream (Estropipate) replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps rebuild and maintain vaginal tissue, relieving symptoms of vaginal dryness, soreness, irritation, and painful sex.Activella (Estradiol / Norethindrone) contains two hormones that work to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norethindrone (a progestin) protects the uterus from damage.
Type of medication
Ogen Vaginal CreamEstradiol Norethindrone
Prescription only
Prescription only
Available as
Ogen Vaginal CreamEstradiol Norethindrone
  • Vaginal cream, gel, or ointment
  • Pill
Used for
Ogen Vaginal CreamEstradiol Norethindrone
  • Vaginal Dryness And Inflammation
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
Ogen Vaginal CreamEstradiol Norethindrone
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Ogen Vaginal Cream (estropipate) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Activella (estradiol / norethindrone) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Pain
Ogen Vaginal CreamEstradiol Norethindrone
  • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Ogen Vaginal Cream (Estropipate) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
No pain related info.
Weight
Ogen Vaginal CreamEstradiol Norethindrone
No weight related info.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Activella (Estradiol / Norethindrone) is a mixture of estrogen and progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
Upsides and benefits
Ogen Vaginal CreamEstradiol Norethindrone
  • Ogen Vaginal Cream (Estropipate) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Generally works well with few side effects.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Ogen Vaginal Cream (Estropipate) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
  • Activella (Estradiol / Norethindrone) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Good choice for women with intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Mimvey brand is less expensive than other estrogen/progestin combination medicines.
Downsides and risks
Ogen Vaginal CreamEstradiol Norethindrone
  • No vaginal sex immediately after using Ogen Vaginal Cream (Estropipate) to prevent your partner from being exposed to the medicine.
  • The cream can weaken latex (rubber) condoms, cervical caps, and diaphrams. Don't use these within 72 hours after a dose.
  • Inserting the applicator can possibly cause discomfort or infection.
  • If you have your uterus, you have to use Ogen Vaginal Cream (Estropipate) with another hormone called progestin to lower your risk of uterine cancer.
  • More potential side effects since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
Tips from our pharmacists for people taking the medication
Ogen Vaginal CreamEstradiol Norethindrone
  • Apply Ogen Vaginal Cream (Estropipate) directly to your vagina daily.
  • Attach the applicator to the tube and squeeze it to get your dose into the applicator. Insert the applicator deeply into your vagina and press the plunger to release all the medicine.
  • Best used at bedtime to increase effectiveness.
  • Consider wearing a panty liner.
  • Clean the applicator with soap and warm water after each use.
  • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
  • Tell your doctor about any unusual vaginal bleeding.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
Learn more
More about Ogen Vaginal CreamSide effectsAlternativesFDA package insert
Have you used Ogen Vaginal Cream (estropipate)?
Worth itNot sureNot worth it
More about Estradiol NorethindroneSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Activella (estradiol / norethindrone)?
Worth itNot sureNot worth it