Compare Ogen Vaginal Cream vs. Estring

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ogen Vaginal Cream
(Estropipate)

Estring
(Estradiol Vaginal Ring)

Relieves vaginal dryness due to menopause. Ogen Vaginal Cream (Estropipate) works well for vaginal problems caused by menopause. It has fewer side effects than estrogen pills, but you might still need to use it every day.Relieves vaginal dryness due to menopause. Estring (Estradiol Vaginal Ring) is a vaginal ring that may be less of a hassle than estrogen pills, gels, patches, or vaginal creams, but comes with the same side effects.
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Reviews & ratings
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Reviews for Estring (Estradiol Vaginal Ring)
62%
+62% vs. Ogen Vaginal Cream (Estropipate)
40%
+40% vs. Ogen Vaginal Cream (Estropipate)
18%
18% vs. Ogen Vaginal Cream (Estropipate)
Side effects
Ogen Vaginal CreamEstring

The Ogen Vaginal Cream FDA package insert doesn’t have numbers about how common side effects are.

More about Ogen Vaginal Cream side effects »

The Estring FDA package insert doesn’t have numbers about how common side effects are.

More about Estring side effects »
How it works
Ogen Vaginal CreamEstring
Ogen Vaginal Cream (Estropipate) replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps rebuild and maintain vaginal tissue, relieving symptoms of vaginal dryness, soreness, irritation, and painful sex.Estring (Estradiol Vaginal Ring) is a vaginal ring that replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps rebuild and maintain vaginal tissue, relieving symptoms of vaginal dryness, soreness, irritation, and painful sex.
Type of medication
Ogen Vaginal CreamEstring
Hormone replacement
Estrogen derivative
Prescription only
Hormone replacement
Estrogen derivative
Prescription only
Available as
Ogen Vaginal CreamEstring
  • Vaginal cream, gel, or ointment
  • Vaginal ring
Used for (click to learn more)
Ogen Vaginal CreamEstring
  • Vaginal dryness and inflammation
  • Vaginal dryness and inflammation
Risk factors for serious side effects
Ogen Vaginal CreamEstring
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
  • Women of childbearing age
Detailed Ogen Vaginal Cream (Estropipate) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
  • Women of childbearing age
  • High levels of triglycerides
Detailed Estring (Estradiol Vaginal Ring) risks & warnings »
Pregnancy category
Ogen Vaginal CreamEstring
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
  • No vaginal sex immediately after using Ogen Vaginal Cream (Estropipate) to prevent your partner from being exposed to the medicine.
  • Ogen Vaginal Cream (Estropipate) relieves vaginal dryness and irritation to make sex more enjoyable.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Ogen Vaginal Cream (Estropipate) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
  • Estring (Estradiol Vaginal Ring) relieves vaginal dryness and irritation to make sex more enjoyable.
  • You don’t have to remove Estring (Estradiol Vaginal Ring) to treat a vaginal infection or have sex.
Sleep
No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
Ogen Vaginal CreamEstring
  • Ogen Vaginal Cream (Estropipate) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Generally works well with few side effects.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Ogen Vaginal Cream (Estropipate) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Estring (Estradiol Vaginal Ring) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Good option for people who don't want to take oral pills.
  • Generally works well with fewer side effects.
  • Many women think Estring (Estradiol Vaginal Ring) is easy to insert and comfortable to use.
  • In a 12-week study, Estring (Estradiol Vaginal Ring) worked well to improve vaginal problems, reduced pain during urination, and sudden urges to urinate.
  • Estring (Estradiol Vaginal Ring) slowly releases estrogen over the 90 days the ring is in place, so you only have to remove and insert a new one every three months.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
Downsides and risks
Ogen Vaginal CreamEstring
  • No vaginal sex immediately after using Ogen Vaginal Cream (Estropipate) to prevent your partner from being exposed to the medicine.
  • The cream can weaken latex (rubber) condoms, cervical caps, and diaphrams. Don't use these within 72 hours after a dose.
  • Inserting the applicator can possibly cause discomfort or infection.
  • If you have your uterus, you have to use Ogen Vaginal Cream (Estropipate) with another hormone called progestin to lower your risk of uterine cancer.
  • Estring (Estradiol Vaginal Ring) may not be the best estrogen product if you have a narrow vagina or frequent vaginal infections.
  • The ring can fall out without you noticing it.
  • Increases your risk of endometrial (uterine cancer).
  • If you have your uterus, you might need to use Estring (Estradiol Vaginal Ring) with another hormone called progestin to lower your risk of uterine cancer.
  • Can be expensive since it's only available as a brand name product.
Tips from our pharmacists for people taking the medication
Ogen Vaginal CreamEstring
  • Apply Ogen Vaginal Cream (Estropipate) directly to your vagina daily.
  • Attach the applicator to the tube and squeeze it to get your dose into the applicator. Insert the applicator deeply into your vagina and press the plunger to release all the medicine.
  • Best used at bedtime to increase effectiveness.
  • Consider wearing a panty liner.
  • Clean the applicator with soap and warm water after each use.
  • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
  • Tell your doctor about any unusual vaginal bleeding.
  • Insert the ring as deeply as possible into your vagina. You shouldn't feel the ring once it's inserted.
  • The ring is good for 90 days in your vagina. If it falls out before the 90 days are up, just clean it with warm water and reinsert.
  • You don’t have to remove Estring (Estradiol Vaginal Ring) to treat a vaginal infection or have sex.
  • It can take up to 2 to 3 weeks to feel the full benefits.
  • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
  • Tell your doctor about any unusual vaginal bleeding.
Learn more
More about Ogen Vaginal CreamSide effectsAlternativesFDA package insert
More about EstringSide effectsReviews & ratingsAlternativesFDA package insert