Compare Ogen Vaginal Cream vs. Premarin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ogen Vaginal Cream
(Estropipate)

Premarin
(Conjugated Estrogens)

Relieves vaginal dryness due to menopause. Ogen Vaginal Cream (Estropipate) works well for vaginal problems caused by menopause. It has fewer side effects than estrogen pills, but you might still need to use it every day.Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. Premarin (Conjugated Estrogens) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.
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Reviews & ratings
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Reviews for Premarin (Conjugated Estrogens)
50%
+50% vs. Ogen Vaginal Cream (Estropipate)
43%
+43% vs. Ogen Vaginal Cream (Estropipate)
11%
11% vs. Ogen Vaginal Cream (Estropipate)
Side effects
Ogen Vaginal CreamPremarin

The Ogen Vaginal Cream FDA package insert doesn’t have numbers about how common side effects are.

More about Ogen Vaginal Cream side effects »
  • Abdominal pain 5%
  • Back pain 4%
  • Muscle weakness 4%
  • Breast pain 4%
  • Passing gas 4%
  • Thick vaginal discharge 3%
  • Vaginal moniliasis 2%
  • Nervousness 2%
  • Itching 2%
  • Leg cramps 2%
More Premarin side effects »
How it works
Ogen Vaginal CreamPremarin
Ogen Vaginal Cream (Estropipate) replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps rebuild and maintain vaginal tissue, relieving symptoms of vaginal dryness, soreness, irritation, and painful sex.Premarin (Conjugated Estrogens) is an oral medication that replaces estrogen hormones during and after menopause. Higher levels of estrogen lower menopause-related hot flashes, flushing, night sweats, vaginal problems, and bone loss.
Type of medication
Ogen Vaginal CreamPremarin
Hormone replacement
Estrogen derivative
Prescription only
Hormone replacement
Estrogen derivative
Prescription only
Available as
Ogen Vaginal CreamPremarin
  • Vaginal cream, gel, or ointment
  • Pill
Used for (click to learn more)
Ogen Vaginal CreamPremarin
  • Vaginal dryness and inflammation
  • Hot flashes and night sweats
Risk factors for serious side effects
Ogen Vaginal CreamPremarin
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
  • Women of childbearing age
Detailed Ogen Vaginal Cream (Estropipate) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
      • Prior severe allergic reaction to Premarin (Conjugated Estrogens)
      • Women of childbearing age
      • High levels of triglycerides
      Detailed Premarin (Conjugated Estrogens) risks & warnings »
      Pregnancy category
      Ogen Vaginal CreamPremarin
      XFDA pregnancy category (Unsafe)

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      See the FDA package insert
      XFDA pregnancy category (Unsafe)

      Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

      See the FDA package insert
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      • No vaginal sex immediately after using Ogen Vaginal Cream (Estropipate) to prevent your partner from being exposed to the medicine.
      • Ogen Vaginal Cream (Estropipate) relieves vaginal dryness and irritation to make sex more enjoyable.
      • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Ogen Vaginal Cream (Estropipate) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
      • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      Ogen Vaginal CreamPremarin
      • Ogen Vaginal Cream (Estropipate) relieves vaginal dryness and irritation to make sex more enjoyable.
      • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
      • Generally works well with few side effects.
      • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Ogen Vaginal Cream (Estropipate) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
      • Premarin (Conjugated Estrogens) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
      • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
      • Improves mood, energy, and mental alertness for some people.
      • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
      • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
      Downsides and risks
      Ogen Vaginal CreamPremarin
      • No vaginal sex immediately after using Ogen Vaginal Cream (Estropipate) to prevent your partner from being exposed to the medicine.
      • The cream can weaken latex (rubber) condoms, cervical caps, and diaphrams. Don't use these within 72 hours after a dose.
      • Inserting the applicator can possibly cause discomfort or infection.
      • If you have your uterus, you have to use Ogen Vaginal Cream (Estropipate) with another hormone called progestin to lower your risk of uterine cancer.
      • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
      • Increases your risk of uterine and breast cancer.
      • If you have your uterus, you have to take Premarin (Conjugated Estrogens) with another hormone called progestin to lower your risk of uterine cancer.
      • Increases your risk of developing blood clots and stroke.
      • Can't be used in people with liver problems.
      • Can be expensive since it's only available as a brand name product.
      Tips from our pharmacists for people taking the medication
      Ogen Vaginal CreamPremarin
      • Apply Ogen Vaginal Cream (Estropipate) directly to your vagina daily.
      • Attach the applicator to the tube and squeeze it to get your dose into the applicator. Insert the applicator deeply into your vagina and press the plunger to release all the medicine.
      • Best used at bedtime to increase effectiveness.
      • Consider wearing a panty liner.
      • Clean the applicator with soap and warm water after each use.
      • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
      • Tell your doctor about any unusual vaginal bleeding.
      • Take Premarin (Conjugated Estrogens) at the same time each day. If you miss a dose, take it as soon as possible, but if it’s almost time for your next dose, take only that dose.
      • Use the lowest dose possible of Premarin (Conjugated Estrogens) and take it only as long as needed. Talk to your doctor regularly to see if you still need treatment. If you’re taking Premarin (Conjugated Estrogens) only for vaginal symptoms or to prevent bone loss, there are other medicines that can work better with fewer side effects (like a vaginal cream for menopause symptoms, or non-estrogen medicine for bone loss).
      • Can cause nausea, dizziness, bloating and breast tenderness.
      • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
      • Tell your doctor about any unusual vaginal bleeding.
      Learn more
      More about Ogen Vaginal CreamSide effectsAlternativesFDA package insert
      More about PremarinSide effectsReviews & ratingsAlternativesFDA package insert