Compare Ogen Vaginal Cream vs. Prempro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Ogen Vaginal Cream
(Estropipate)

Prempro
(Conjugated Estrogens / Medroxyprogesterone Acetate)

Relieves vaginal dryness due to menopause. Ogen Vaginal Cream (Estropipate) works well for vaginal problems caused by menopause. It has fewer side effects than estrogen pills, but you might still need to use it every day.Coming soon.
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Side effects
Ogen Vaginal CreamPrempro

The Ogen Vaginal Cream FDA package insert doesn’t have numbers about how common side effects are.

More about Ogen Vaginal Cream side effects »

We haven’t found good data for Prempro side effects.

FDA side effect reports for Prempro »
How it works
Ogen Vaginal CreamPrempro
Ogen Vaginal Cream (Estropipate) replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps rebuild and maintain vaginal tissue, relieving symptoms of vaginal dryness, soreness, irritation, and painful sex.Coming soon.
Type of medication
Ogen Vaginal CreamPrempro
Hormone replacement
Estrogen derivative
Prescription only
Coming soon.
Available as
Ogen Vaginal CreamPrempro
  • Vaginal cream, gel, or ointment
  • Pill
Used for (click to learn more)
Ogen Vaginal CreamPrempro
  • Vaginal dryness and inflammation
  • Menopause - Moderate to severe abnormal vasomotor function Menopause - Moderate to severe vaginal atrophy - Moderate to severe vulvar atrophy Postmenopausal osteoporosis
Risk factors for serious side effects
Ogen Vaginal CreamPrempro
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
  • Women of childbearing age
Detailed Ogen Vaginal Cream (Estropipate) risks & warnings »
Coming soon.
Pregnancy category
Ogen Vaginal CreamPrempro
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
  • No vaginal sex immediately after using Ogen Vaginal Cream (Estropipate) to prevent your partner from being exposed to the medicine.
  • Ogen Vaginal Cream (Estropipate) relieves vaginal dryness and irritation to make sex more enjoyable.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Ogen Vaginal Cream (Estropipate) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
Ogen Vaginal CreamPrempro
  • Ogen Vaginal Cream (Estropipate) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Generally works well with few side effects.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Ogen Vaginal Cream (Estropipate) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
Coming soon.
Downsides and risks
Ogen Vaginal CreamPrempro
  • No vaginal sex immediately after using Ogen Vaginal Cream (Estropipate) to prevent your partner from being exposed to the medicine.
  • The cream can weaken latex (rubber) condoms, cervical caps, and diaphrams. Don't use these within 72 hours after a dose.
  • Inserting the applicator can possibly cause discomfort or infection.
  • If you have your uterus, you have to use Ogen Vaginal Cream (Estropipate) with another hormone called progestin to lower your risk of uterine cancer.
Coming soon.
Tips from our pharmacists for people taking the medication
Ogen Vaginal CreamPrempro
  • Apply Ogen Vaginal Cream (Estropipate) directly to your vagina daily.
  • Attach the applicator to the tube and squeeze it to get your dose into the applicator. Insert the applicator deeply into your vagina and press the plunger to release all the medicine.
  • Best used at bedtime to increase effectiveness.
  • Consider wearing a panty liner.
  • Clean the applicator with soap and warm water after each use.
  • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
  • Tell your doctor about any unusual vaginal bleeding.
Coming soon.
Learn more
More about Ogen Vaginal CreamSide effectsAlternativesFDA package insert
More about PremproSide effectsReviews & ratingsFDA package insert