Compare Oleptro vs. Ambien

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Oleptro
(Trazodone)

Ambien
(zolpidem)

Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.Helps you sleep. Ambien (zolpidem) aids in falling asleep and staying asleep, but it can be habit-forming and might be more likely than other sleep medicines to cause side effects.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.9Oleptro
Reviews for Oleptro
73%
of people (All ages) say Oleptro is worth it
49%
say it works well
24%
say it's a big hassle
Have you used Oleptro (Trazodone)?
Worth itNot sureNot worth it
Reviews for Ambien
67%
+6% better vs. Oleptro
50%
-1% worse vs. Oleptro
16%
-8% worse vs. Oleptro
1375 reviews
Have you used Ambien (zolpidem)?
Worth itNot sureNot worth it
Side effects
OleptroAmbien
  • Incoordination 2%
  • Ejaculation disorders 2%
  • Decreased libido 2%
  • Hypotension 4%
  • Diarrhea 3%
  • Syncope 4%
  • Musculoskeletal Aches/Pains 2%
  • Tremors 1%
  • Weight Gain 3%
More Oleptro side effects »
  • Drowsiness 2%
  • Flu-like symptoms 2%
  • Racing heart 2%
  • Lightheadedness 1%
  • Depression 1%
  • Constipation 1%
  • Rash 1%
  • Dry mouth 2%
  • Back pain 1%
More Ambien side effects »
How it works
OleptroAmbien
Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Ambien (zolpidem) is in a class of drugs called sedative-hypnotics. It interacts with your brain to make you relaxed and sleepy.
Type of medication
OleptroAmbien
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
OleptroAmbien
  • Pill
  • Extended release
  • Pill
  • Oral spray
  • Sublingual pill
Used for
OleptroAmbien
Risk factors for serious side effects
OleptroAmbien
  • Age 24 years or younger
  • History of seizures
  • Alcoholism
  • Eating disorder
  • Higher dose
Detailed Oleptro (Trazodone) risks & warnings »
  • Continuous use of Ambien (zolpidem) for 2 weeks or more
  • Alcohol
  • Taking other medications that make you less alert
  • Less than 8 hours of sleep.
  • Undiagnosed psychiatric conditions
Detailed Ambien (zolpidem) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
OleptroAmbien
No alcohol related info.
  • Avoid alcohol and drugs when taking Ambien (zolpidem).
Kidneys and liver
OleptroAmbien
No kidneys and liver related info.
  • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
Sleep
OleptroAmbien
No sleep related info.
  • Ambien (zolpidem) makes you feel drowsy and sleepy, potentially leading to falls and severe injuries. This is especially a risk if you're older. Falls from sleep medicines like Ambien (zolpidem) have caused severe injuries such as hip fractures and head injury. You may need a lower dose if you're taking other medications that also cause drowsiness. Check with your doctor first.
  • Only take it if you have time to sleep for at least 8 hours.
  • Effective at helping people fall asleep faster and sleep longer.
Upsides and benefits
OleptroAmbien
  • Commonly used in lower doses to help treat sleep problems (insomnia).
  • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
  • Fewer sexual side effects than many other antidepressants.
  • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
  • Comes as a generic medication and is cheaper than many other sleep aides.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Effective at helping people fall asleep faster and sleep longer.
  • Extended release form is particularly good for staying asleep, and you can use it for longer than the immediate release form.
  • Generic is available.
Downsides and risks
OleptroAmbien
  • Not as effective as other medications for depression.
  • More sedating than other antidepressants.
  • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Not typically used for long-term treatment because it can be habit-forming.
  • Some people find that Ambien (zolpidem) becomes less effective over time.
  • More likely to cause sleep-walking, sleep-driving, and sleep-eating.
  • Might not be safe if you have problems with your liver, kidneys, lungs, or if you have a history of depression.
Tips from our pharmacists for people taking the medication
OleptroAmbien
  • Makes you sleepy. Take at bedtime.
  • Can cause temporary dry mouth and upset stomach.
  • Seek medical attention for unwanted, persistent erection.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Take 30 to 45 minutes before bedtime.
  • Only take it if you have time to sleep for at least 8 hours.
  • Can be addictive. Meant for short-term treatment. Dependence can form after daily use for 2 weeks.
  • Avoid alcohol and drugs when taking Ambien (zolpidem).
  • Withdrawal symptoms can occur if you abruptly stop the drug and you've been regularly using it. The symptoms usually resolve in 1 to 2 nights.
  • Report any confusion or changes in thoughts or behavior.
Learn more
More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Oleptro (Trazodone)?
Worth itNot sureNot worth it
More about AmbienSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Ambien (zolpidem)?
Worth itNot sureNot worth it