Compare Oleptro vs. amoxapine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Oleptro
(trazodone)

Asendin
(amoxapine)

Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.Stabilizes your mood. While Asendin (amoxapine) can treat depression, you have to take it several times a day and it can make you feel sleepy.
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Reviews & ratings
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4.9Oleptro
Reviews for Oleptro (trazodone)
73%
of people (All ages) say Oleptro (trazodone) is worth it
49%
say it works well
24%
say it's a big hassle
Have you used Oleptro (trazodone)?
Worth itNot sureNot worth it

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Have you used Asendin (amoxapine)?
Worth itNot sureNot worth it
Side effects
Oleptroamoxapine
  • Somnolence/sedation 27%
  • Drowsiness 21%
  • Dry mouth 14%
  • Headache 6%
  • Dizziness/lightheadedness 13%
  • Dizziness 13%
  • Nausea 8%
  • Fatigue 7%
More Oleptro side effects »
  • Drowsiness or fatigue 14%
  • Dry mouth 14%
  • Constipation 12%
  • Vision changes 7%
More amoxapine side effects »
How it works
Oleptroamoxapine
Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Asendin (amoxapine) is a tricyclic antidepressant. It increases the activity of serotonin and norepinephrine in your brain which regulate your mood.
Type of medication
Oleptroamoxapine
Prescription only
Prescription only
Available as
Oleptroamoxapine
  • Pill
  • Extended release
  • Pill
Used for
Oleptroamoxapine
Risk factors for serious side effects
Oleptroamoxapine
  • Age 24 years or younger
  • History of seizures
  • Alcoholism
  • Eating disorder
  • Higher dose
  • Drug interactions
    • Age 65 years or older
    • Alcohol
    • Taking other medicines that make you less alert
    Detailed Oleptro (trazodone) risks & warnings »
    • People under age 24
    • Glaucoma
      • Taking antidepressants
      • Taking opioids for pain relief or medicines for anxiety
      • Over age 65
      Detailed Asendin (amoxapine) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Food
      Oleptroamoxapine
      No food related info.
      • Take Asendin (amoxapine) with food to avoid stomach upset.
      Sleep
      Oleptroamoxapine
      No sleep related info.
      • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
      Upsides and benefits
      Oleptroamoxapine
      • Commonly used in lower doses to help treat sleep problems (insomnia).
      • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
      • Fewer sexual side effects than many other antidepressants.
      • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
      • Comes as a generic medication and is cheaper than many other sleep aides.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      • Asendin (amoxapine) can be used to treat more severe forms of depression.
      • Compared to similar medicines, Asendin (amoxapine) improves the mood in depression more quickly.
      • Asendin (amoxapine) is available as generic.
      Downsides and risks
      Oleptroamoxapine
      • Not as effective as other medications for depression.
      • More sedating than other antidepressants.
      • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
      • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      • Asendin (amoxapine) is not a first choice medicine for depression because of side effects.
      • In some people, Asendin (amoxapine) can stop working as early as 2-3 months after you start taking it.
      • Not recommended in older people, children under 16, or people who've had a history of seizures.
      Tips from our pharmacists for people taking the medication
      Oleptroamoxapine
      • Makes you sleepy. Take at bedtime.
      • Can cause temporary dry mouth and upset stomach.
      • Seek medical attention for unwanted, persistent erection.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      • You can feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
      • You might not notice any changes in your mood for at least a few weeks.
      • Take Asendin (amoxapine) with food to avoid stomach upset.
      • You're more likely to be dehydrated and constipated. Drink plenty of fluids and be careful not to get overheated if you're out in the sun.
      • Don't stop taking Asendin (amoxapine) without talking to your doctor. Stopping Asendin (amoxapine) suddenly can be very dangerous.
      Learn more
      More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Oleptro (trazodone)?
      Worth itNot sureNot worth it
      More about amoxapineSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Asendin (amoxapine)?
      Worth itNot sureNot worth it