Compare Oleptro vs. Ativan

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Oleptro
(Trazodone)

Ativan
(Lorazepam)

Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.Helps you relax. Ativan (Lorazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and sleep. Less likely to have drug interactions, but more likely to cause withdrawal symptoms compared to similar drugs.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.833333333333333Oleptro
Reviews for Oleptro (Trazodone)
72%
of people say Oleptro (Trazodone) is worth it
48%
say it works well
24%
say it's a big hassle
Reviews for Ativan (Lorazepam)
70%
2% vs. Oleptro (Trazodone)
50%
+2% vs. Oleptro (Trazodone)
15%
+9% vs. Oleptro (Trazodone)
Side effects
OleptroAtivan
  • Somnolence/sedation 27%
  • Drowsiness 21%
  • Dry mouth 14%
  • Dizziness/lightheadedness 13%
  • Dizziness 13%
  • Blurred vision 11%
  • Nausea 8%
  • Fatigue 7%
  • Skin condition/edema 6%
  • Headache 6%
More Oleptro side effects »

The Ativan FDA package insert doesn’t have numbers about how common side effects are.

More about Ativan side effects »
How it works
OleptroAtivan
Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Ativan (Lorazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and can cause sleepiness.
Type of medication
OleptroAtivan
Antidepressant
Serotonin antagonist and reuptake inhibitor
Prescription only
Anti-anxiety
Benzodiazepine
Prescription only
Available as
OleptroAtivan
  • Pill
  • Extended release
  • Pill
  • Liquid
Used for (click to learn more)
OleptroAtivan
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Oleptro (Trazodone)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Ativan (Lorazepam)
Risk factors for serious side effects
OleptroAtivan
  • Age 24 years or younger
  • History of seizures
  • Alcoholism
  • Eating disorder
  • Higher dose
  • Drug interactions
    • Age 65 years or older
    • Alcohol
    • Taking other medicines that make you less alert
    Detailed Oleptro (Trazodone) risks & warnings »
    • Taking more than the prescribed dose
    • Taking longer than 4 weeks
    • History of drug abuse
    • Long-term use
      • Alcohol
      • Taking other medicines that make you less alert
        Detailed Ativan (Lorazepam) risks & warnings »
        Pregnancy category
        OleptroAtivan
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        DFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.
        • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
        • Not safe to use with alcohol.
        Food
        No specific food-related info.No specific food-related info.
        Kidneys and liver
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        Sex
        • Fewer sexual side effects than many other antidepressants.
        • Seek medical attention for unwanted, persistent erection.
        • Rarely, Oleptro (Trazodone) can cause a painful, persistent erection for 4 hours or more. Seek medical attention.
        No specific sex-related info.
        Sleep
        • Commonly used in lower doses to help treat sleep problems (insomnia).
        • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
        • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
        • Comes as a generic medication and is cheaper than many other sleep aides.
        • Can cause memory problems, drowsiness, dizziness, and confusion.
        • Can cause temporary dizziness and drowsiness.
        • Stopping Ativan (Lorazepam) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and muscle pain or burning. Withdrawal symptoms can last 6 weeks or longer. Work with your doctor to gradually reduce your dose.
        Weight
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        OleptroAtivan
        • Commonly used in lower doses to help treat sleep problems (insomnia).
        • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
        • Fewer sexual side effects than many other antidepressants.
        • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
        • Comes as a generic medication and is cheaper than many other sleep aides.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        • Effective at relieving short-term anxiety and sleeplessness.
        • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
        • Less likely to have drug interactions compared to other benzodiazepines, so it might be a better option if you're taking multiple medications.
        Downsides and risks
        OleptroAtivan
        • Not as effective as other medications for depression.
        • More sedating than other antidepressants.
        • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
        • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        • Can cause memory problems, drowsiness, dizziness, and confusion.
        • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
        • Compared to other benzodiazepines, more likely to cause withdrawal if you take it for a long time and then stop suddenly.
        • Most people find that it gets less effective over time.
        Tips from our pharmacists for people taking the medication
        OleptroAtivan
        • Makes you sleepy. Take at bedtime.
        • Can cause temporary dry mouth and upset stomach.
        • Seek medical attention for unwanted, persistent erection.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        • Good for short-term relief of anxiety symptoms.
        • Starts working in 45 minutes when swallowed.
        • Starts working in 10 to 20 minutes when dissolved under your tongue.
        • Can cause temporary dizziness and drowsiness.
        • Addictive. Long-term use can cause dependence or abuse.
        • Not safe to use with alcohol.
        Learn more
        More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert
        More about AtivanSide effectsReviews & ratingsAlternativesFDA package insert