Compare Oleptro vs. Estazolam

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.Helps you stay asleep longer. Prosom (estazolam) can help you sleep, but you might feel hungover the next day.
Reviews & ratings
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Reviews for Oleptro
of people (All ages) say Oleptro is worth it
say it works well
say it's a big hassle
Have you used Oleptro (trazodone)?
Worth itNot sureNot worth it

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Have you used Prosom (estazolam)?
Worth itNot sureNot worth it
Side effects
  • Somnolence/Sedation 27%
  • Drowsiness 21%
  • Dry Mouth 14%
  • Headache 6%
  • Dizziness/Lightheadedness 13%
  • Dry mouth 12%
  • Dizziness 13%
  • Nausea 8%
  • Fatigue 7%
More Oleptro side effects »
  • Sleepiness 15%
  • Weakness 3%
  • Difficulty controlling muscles 4%
  • Dizziness 4%
  • Abnormal coordination 3%
  • Leg and foot pain 1%
More Estazolam side effects »
How it works
Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Prosom (estazolam) is a benzodiazepine. It helps you stay asleep by improving the quality of your sleep so you don't wake up as much at night.
Type of medication
Prescription onlyPrescription only
Available as
  • Pill
  • Extended release
  • Pill
Used for
Risk factors for serious side effects
  • Age 24 years or younger
  • History of seizures
  • Alcoholism
  • Eating disorder
  • Higher dose
Detailed Oleptro (trazodone) risks & warnings »
  • Using Prosom (estazolam) for more than 10 days
  • Drinking alcohol
  • Taking sedative medicines
  • People age 65 or older
Detailed Prosom (estazolam) risks & warnings »

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

No alcohol related info.
  • Don't drink alcohol or take other narcotics with Prosom (estazolam) because it can slow your breathing.
Upsides and benefits
  • Commonly used in lower doses to help treat sleep problems (insomnia).
  • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
  • Fewer sexual side effects than many other antidepressants.
  • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
  • Comes as a generic medication and is cheaper than many other sleep aides.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Prosom (estazolam) is available in generic.
Downsides and risks
  • Not as effective as other medications for depression.
  • More sedating than other antidepressants.
  • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Prosom (estazolam) isn't recommended if you're age 65 or older because the side effects can be more intense.
  • You can become dependent on Prosom (estazolam) if you take it for more than a few weeks.
  • If you stop Prosom (estazolam) suddenly after taking it for a while, your insomnia might come back even worse than when you started.
Tips from our pharmacists for people taking the medication
  • Makes you sleepy. Take at bedtime.
  • Can cause temporary dry mouth and upset stomach.
  • Seek medical attention for unwanted, persistent erection.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Don't take Prosom (estazolam) unless you know you'll be going to sleep right away.
  • Make sure you can sleep for at least 8 hours before you take it.
  • Prosom (estazolam) works best if you develop good sleeping habits.
  • Take Prosom (estazolam) for the shortest amount of time needed to treat your insomnia since it can be addicting.
  • Don't drink alcohol or take other narcotics with Prosom (estazolam) because it can slow your breathing.
Learn more
More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Oleptro (trazodone)?
Worth itNot sureNot worth it
More about EstazolamSide effectsAlternativesFDA package insert
Have you used Prosom (estazolam)?
Worth itNot sureNot worth it