Compare Oleptro vs. Valium

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Oleptro
(trazodone)

Valium
(diazepam)

Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.Helps you relax. Valium (Diazepam) is okay for occasional or short-term use (up to 4 weeks) for anxiety and for pain and sleeplessness from muscle spasm. Less severe withdrawal symptoms compared to similar drugs.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.9Oleptro
Reviews for Oleptro
73%
of people (All ages) say Oleptro is worth it
49%
say it works well
24%
say it's a big hassle
Have you used Oleptro (trazodone)?
Worth itNot sureNot worth it
Reviews for Valium
70%
+3% better vs. Oleptro
53%
-4% worse vs. Oleptro
15%
-9% worse vs. Oleptro
976 reviews
Have you used Valium (diazepam)?
Worth itNot sureNot worth it
Side effects
OleptroValium
  • Somnolence/Sedation 27%
  • Drowsiness 21%
  • Dry Mouth 14%
  • Headache 6%
  • Dizziness/Lightheadedness 13%
  • Dry mouth 12%
  • Dizziness 13%
  • Nausea 8%
  • Fatigue 7%
More Oleptro side effects »

The Valium FDA package insert doesn’t have numbers about how common side effects are.

More about Valium side effects »
How it works
OleptroValium
Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Valium (Diazepam) is a fast-acting benzodiazepine. It affects neurotransmitters in the brain and calms the nervous system. This reduces anxiety and muscle spasms, and causes sleepiness.
Type of medication
OleptroValium
Prescription onlyPrescription only
Available as
OleptroValium
  • Pill
  • Extended release
  • Pill
  • Liquid
  • Rectal gel
Used for
OleptroValium
Risk factors for serious side effects
OleptroValium
  • Age 24 years or younger
  • History of seizures
  • Alcoholism
  • Eating disorder
  • Higher dose
Detailed Oleptro (trazodone) risks & warnings »
  • Taking more than the prescribed dose
  • Taking longer than 4 weeks
  • History of drug abuse
  • Long-term use
  • Alcohol
Detailed Valium (diazepam) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
OleptroValium
No alcohol related info.
  • Not safe to use with alcohol.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
Kidneys and liver
OleptroValium
No kidneys and liver related info.
  • Processed by the liver, so might not be the best choice if you have liver problems.
Sleep
OleptroValium
No sleep related info.
  • Can cause temporary dizziness and drowsiness.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
Upsides and benefits
OleptroValium
  • Commonly used in lower doses to help treat sleep problems (insomnia).
  • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
  • Fewer sexual side effects than many other antidepressants.
  • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
  • Comes as a generic medication and is cheaper than many other sleep aides.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Effective at relieving short-term anxiety and sleeplessness.
  • Can be used together with antidepressants to manage anxiety disorders. Especially helpful for anxiety symptoms while you wait for an antidepressant to kick in (it can take several weeks).
  • Effective at relieving muscle spasms caused by a variety of conditions.
  • Less severe withdrawal symptoms compared to other benzodiazepines.
Downsides and risks
OleptroValium
  • Not as effective as other medications for depression.
  • More sedating than other antidepressants.
  • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Processed by the liver, so might not be the best choice if you have liver problems.
  • Can cause memory problems, drowsiness, dizziness, and confusion.
  • Can be habit-forming, so it's not typically used for long-term treatment, or for people who've had problems with drug or alcohol abuse.
  • Most people find that it gets less effective over time.
Tips from our pharmacists for people taking the medication
OleptroValium
  • Makes you sleepy. Take at bedtime.
  • Can cause temporary dry mouth and upset stomach.
  • Seek medical attention for unwanted, persistent erection.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • Good for short-term relief of anxiety symptoms.
  • Starts working in 30 minutes when swallowed.
  • Helpful with muscle spasms.
  • Can cause temporary dizziness and drowsiness.
  • Addictive. Long-term use can cause dependence or abuse.
  • Not safe to use with alcohol.
Learn more
More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Oleptro (trazodone)?
Worth itNot sureNot worth it
More about ValiumSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Valium (diazepam)?
Worth itNot sureNot worth it