Compare Oleptro vs. Zoloft

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Oleptro
(trazodone)

Zoloft
(sertraline)

Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.
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Prices and coupon for 30 (50mg) tablets of trazodone
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Prices and coupon for 30 (100mg) tablets of sertraline
Reviews & ratings
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4.9Oleptro
Reviews for Oleptro (trazodone)
73%
of people (All ages) say Oleptro (trazodone) is worth it
49%
say it works well
24%
say it's a big hassle
Have you used Oleptro (trazodone)?
Worth itNot sureNot worth it
Reviews for Zoloft (sertraline)
59%
-14% worse vs. Oleptro (trazodone)
41%
-8% worse vs. Oleptro (trazodone)
15%
+9% better vs. Oleptro (trazodone)
1472 reviews
Have you used Zoloft (sertraline)?
Worth itNot sureNot worth it
Side effects
OleptroZoloft
  • Somnolence/sedation 27%
  • Drowsiness 21%
  • Dry mouth 14%
  • Headache 6%
  • Dizziness/lightheadedness 13%
  • Dizziness 13%
  • Nausea 8%
  • Fatigue 7%
More Oleptro side effects »
  • Nausea 10%
  • Diarrhea/loose stools 6%
  • Sleep difficulty 2%
  • Mouth dry 7%
  • Fatigue 10%
  • Dizziness 2%
  • Feeling unwell 2%
  • Indigestion 4%
  • Loss of appetite 5%
  • Lower sex drive 2%
More Zoloft side effects »
How it works
OleptroZoloft
Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.
Type of medication
OleptroZoloft
Prescription only
Prescription only
Available as
OleptroZoloft
  • Pill
  • Extended release
  • Pill
  • Liquid
Used for
OleptroZoloft
Risk factors for serious side effects
OleptroZoloft
  • Age 24 years or younger
  • History of seizures
  • Alcoholism
  • Eating disorder
  • Higher dose
  • Drug interactions
    • Age 65 years or older
    • Alcohol
    • Taking other medicines that make you less alert
    Detailed Oleptro (trazodone) risks & warnings »
    • Under 24 years old
    • Interactions with other medications
        • Stopping Zoloft (Sertraline) suddenly
        • Taking with blood-thinning drugs
        • Elderly
        • Taking with diuretic medications
        Detailed Zoloft (sertraline) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Interactions
        OleptroZoloft
        No interactions related info.
        • It interacts with St. John's Wort and Tryptophan.
        Sex
        OleptroZoloft
        No sex related info.
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        Sleep
        OleptroZoloft
        No sleep related info.
        • Causes less drowsiness than other antidepressants.
        • Zoloft (Sertraline) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
        Upsides and benefits
        OleptroZoloft
        • Commonly used in lower doses to help treat sleep problems (insomnia).
        • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
        • Fewer sexual side effects than many other antidepressants.
        • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
        • Comes as a generic medication and is cheaper than many other sleep aides.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
        • Causes less drowsiness than other antidepressants.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        Downsides and risks
        OleptroZoloft
        • Not as effective as other medications for depression.
        • More sedating than other antidepressants.
        • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
        • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
        • More likely to cause diarrhea than other antidepressants.
        • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        Tips from our pharmacists for people taking the medication
        OleptroZoloft
        • Makes you sleepy. Take at bedtime.
        • Can cause temporary dry mouth and upset stomach.
        • Seek medical attention for unwanted, persistent erection.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
        • It interacts with St. John's Wort and Tryptophan.
        • Stop taking it slowly to avoid getting withdrawal symptoms.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        Learn more
        More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Oleptro (trazodone)?
        Worth itNot sureNot worth it
        More about ZoloftSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Zoloft (sertraline)?
        Worth itNot sureNot worth it