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(Omega-3 Acid)

(Ezetimibe / Simvastatin)

Lowers triglycerides. Omega-3 Acid is good for lowering triglycerides (fats), but some people can't take it due to allergies.Lowers cholesterol. Vytorin is expensive and is no more effective than simvastatin by itself.
How it works
Omega-3 Acid is a cholesterol-lowering medicine. Researchers don't know exactly how it works, but it may help the liver remove triglycerides from your body, and also prevent your body from making more triglycerides.Vytorin is a combination cholesterol-lowering medicine. Simvastatin prevents your body from making "bad" cholesterol (LDL) while raising "good" cholesterol (HDL). Ezetimibe prevents cholesterol absorption in your intestines.
Type of medication
Omega-3 fatty acid
Prescription only
Cholesterol inhibitor
Prescription only
Available as
  • Pill
  • Pill
Used for (click to learn more)
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
of people
say Omega 3 Acid is worth it
say it works well
say it’s a big hassle
4.956521739130435Omega 3 Acid46reviews
of people
say Vytorin is worth it
say it works well
say it’s a big hassle
Side effects
  • Eructation 3%
  • Indigestion 1%
More Omega 3 Acid side effects »
  • Unexplained muscle pain or weakness 1%
  • Ear, nose, or throat infection 1%
  • Pain in extremity 1%
  • Flu 1%
More Vytorin side effects »
Risk factors for serious side effects
Pregnancy category

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
XFDA pregnancy category (Unsafe)
No specific alcohol-related info.
  • People who take Vytorin (Ezetimibe / Simvastatin) have reported liver damage, especially if taken with statins or if you drink large amounts of alcohol. This has been rare. Talk to your doctor if you've ever had liver disease as they may discuss alternatives, or they may monitor your liver with blood tests.
  • You have to take it with food.
  • Take it with food.
No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.
  • People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.
No specific sex-related info.No specific sex-related info.
No specific sleep-related info.No specific sleep-related info.
No specific weight-related info.No specific weight-related info.
Upsides and benefits
  • Lowers triglycerides (fats) when combined with exercise and a low cholesterol diet.
  • In studies, Omega-3 Acid has lowered the risk of stroke and heart attack leading to death, especially in people with high cholesterol or high triglycerides.
  • A 2-in-1 cholesterol-lowering combination medicine.
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
Downsides and risks
  • You can't take it if you're allergic to fish or shellfish.
  • You have to take it with food.
  • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
  • There's no generic available, so it can be expensive.
Tips from our pharmacists for people taking the medication
  • Lowers triglycerides.
  • Take it with food.
  • Swallow capsules whole.
  • Can cause burping and changes in taste.
  • Don't use if you have an allergy to fish or shellfish.
  • You should use this medicine in combination with a healthy diet.
  • Take it in the evening.
  • Avoid grapefruit and grapefruit juice while taking this medicine.
  • Can cause headaches or diarrhea.
  • Call your doctor if you develop muscle pain.
  • Also taking Welchol or Questran? Take this medicine at least 2 hours before or 4 hours after.
Learn more
More about Omega 3 AcidSide effectsReviews & ratingsAlternativesFDA package insert
More about VytorinSide effectsReviews & ratingsAlternativesFDA package insert
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