Compare Omeprazole vs. Maalox

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prilosec
(omeprazole)

Maalox
(aluminum / magnesium / simethicone)

Treats heartburn and stomach ulcers. Prilosec (Omeprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Relieves heartburn and indigestion. Maalox (aluminum / magnesium / simethicone) gives quick relief for heartburn, gas, and bloating, but it may not be as effective or last as long as other antacids.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.53Omeprazole
Reviews for Omeprazole
80%
of people (All ages) say Omeprazole is worth it
59%
say it works well
8%
say it's a big hassle
1167 reviews
Have you used Prilosec (omeprazole)?
Worth itNot sureNot worth it
Reviews for Maalox
69%
+11% better vs. Omeprazole
30%
+29% better vs. Omeprazole
9%
+1% better vs. Omeprazole
213 reviews
Have you used Maalox (aluminum / magnesium / simethicone)?
Worth itNot sureNot worth it
Side effects
OmeprazoleMaalox
  • Upper respiratory infection 75%
  • Fever 33%
  • Headache 7%
  • Abdominal pain 5%
  • Nausea 4%
  • Diarrhea 4%
  • Accidental injuries 4%
  • Flatulence 3%
  • Vomiting 3%
More Omeprazole side effects »

The Maalox FDA package insert doesn’t have numbers about how common side effects are.

More about Maalox side effects »
How it works
OmeprazoleMaalox
Prilosec (Omeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Maalox (aluminum / magnesium / simethicone) is a combination medicine for heartburn and indigestion. Aluminum and magnesium are antacids that treat heartburn and indigestion. Simethicone relieves gas and bloating.
Type of medication
OmeprazoleMaalox
Prescription or OTCOver-the-counter
Available as
OmeprazoleMaalox
  • Extended release
  • Chewable tablet
  • Liquid
Used for
OmeprazoleMaalox
Risk factors for serious side effects
OmeprazoleMaalox
  • Helicobacter pylori infection
  • Autoimmune disease
  • Being hospitalized
  • Antibiotic use
  • Osteoporosis
Detailed Prilosec (omeprazole) risks & warnings »
  • Kidney problems
  • Taking more than the recommended daily maximum
Detailed Maalox (aluminum / magnesium / simethicone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
OmeprazoleMaalox
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
No interactions related info.
Food
OmeprazoleMaalox
  • Take 1 hour before a meal.
  • Talk to your doctor or pharmacist about foods to avoid that can help prevent heartburn.
Kidneys and liver
OmeprazoleMaalox
No kidneys and liver related info.
  • Maalox (aluminum / magnesium / simethicone) contains aluminum and magnesium that can build up in your kidneys if you have kidney problems which can be dangerous. Talk to your doctor or pharmacist before taking Maalox (aluminum / magnesium / simethicone) to see if it is right for you. Don't take more than the maximum amount per day as shown on the label.
Upsides and benefits
OmeprazoleMaalox
  • Most people can take Omeprazole without any noticeable day-to-day side effects.
  • Omeprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Works quickly.
  • Inexpensive and available over-the-counter.
  • Is one of the first choice medications for heartburn relief if you are pregnant.
Downsides and risks
OmeprazoleMaalox
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Omeprazole long-term.
  • Although the generic is affordable, other medications might still be cheaper than Omeprazole.
  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
  • Doesn't last very long. Talk to your doctor or pharmacist if you need longer lasting relief.
  • Is not a good option if you have frequent symptoms (more than 2 times a week). Talk to your doctor or pharmacist about stronger medications.
Tips from our pharmacists for people taking the medication
OmeprazoleMaalox
  • Take 1 hour before a meal.
  • Don't chew or crush capsules; swallow them whole.
  • If you have trouble swallowing you can carefully open the capsules and sprinkle the inside pellets onto applesauce. Swallow the applesauce without chewing or crushing the pellets.
  • When using Omeprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
  • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Omeprazole.
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
  • Starts working within minutes, and lasts for 1-2 hours.
  • If you are using the liquid product, shake well before using.
  • Don't take more than the recommended amount per day on the package. If you need to take this for more than 2 weeks, talk to your doctor.
  • People on a magnesium-restricted diet may need to avoid Maalox. Ask your doctor.
  • Talk to your doctor or pharmacist about foods to avoid that can help prevent heartburn.
  • Eating smaller portion sizes and not eating 3 hours before bedtime can help prevent heartburn.
Learn more
More about OmeprazoleSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Prilosec (omeprazole)?
Worth itNot sureNot worth it
More about MaaloxSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Maalox (aluminum / magnesium / simethicone)?
Worth itNot sureNot worth it