Compare Omeprazole vs. Pepcid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prilosec
(Omeprazole)

Pepcid
(Famotidine)

Treats heartburn and stomach ulcers. Prilosec (Omeprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.5411558669001755Omeprazole
Reviews for Prilosec (Omeprazole)
80%
of people say Prilosec (Omeprazole) is worth it
59%
say it works well
7%
say it's a big hassle
Reviews for Pepcid (Famotidine)
75%
5% vs. Prilosec (Omeprazole)
41%
18% vs. Prilosec (Omeprazole)
8%
1% vs. Prilosec (Omeprazole)
Side effects
OmeprazolePepcid

The Omeprazole FDA package insert doesn’t have numbers about how common side effects are.

More about Omeprazole side effects »

The Pepcid FDA package insert doesn’t have numbers about how common side effects are.

More about Pepcid side effects »
How it works
OmeprazolePepcid
Prilosec (Omeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
OmeprazolePepcid
Acid reducer
Proton pump inhibitor
Prescription or OTC
Acid reducer
Histamine blocker
Prescription or OTC
Available as
OmeprazolePepcid
  • Extended release
  • Pill
  • Chewable tablet
  • Liquid
Used for (click to learn more)
OmeprazolePepcid
Risk factors for serious side effects
OmeprazolePepcid
    • Helicobacter pylori infection
    • Autoimmune disease
    • Being hospitalized
    • Antibiotic use
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
      Detailed Prilosec (Omeprazole) risks & warnings »
        • Current kidney disease
          Detailed Pepcid (Famotidine) risks & warnings »
          Pregnancy category
          OmeprazolePepcid
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Take 1 hour before a meal.
          No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.
          • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
          • Because Pepcid (Famotidine) is processed by the kidney it can cause some worrisome side effects for people with kidney problems. These include confusion, delirium, and a dangerous irregular heartbeat known as QT prolongation. If you have kidney problems, you may need a different dose to prevent this increased risk for side effects.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          OmeprazolePepcid
          • Most people can take Omeprazole without any noticeable day-to-day side effects.
          • Omeprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
          • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
          • Available as both a generic and over-the-counter option, so it's pretty affordable.
          • Most people can take Famotidine without any noticeable day-to-day side effects.
          • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
          • Few drug interactions.
          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
          • Available as both a generic and over-the-counter option, so it's pretty affordable.
          Downsides and risks
          OmeprazolePepcid
          • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
          • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
          • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Omeprazole long-term.
          • Although the generic is affordable, other medications might still be cheaper than Omeprazole.
          • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
          • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
          • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
          • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
          Tips from our pharmacists for people taking the medication
          OmeprazolePepcid
          • Take 1 hour before a meal.
          • Don't chew or crush capsules; swallow them whole.
          • If you have trouble swallowing you can carefully open the capsules and sprinkle the inside pellets onto applesauce. Swallow the applesauce without chewing or crushing the pellets.
          • When using Omeprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
          • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Omeprazole.
          • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
          • Short-term treatment of ulcers and acid reflux.
          Learn more
          More about OmeprazoleSide effectsReviews & ratingsAlternativesFDA package insert
          More about PepcidSide effectsReviews & ratingsAlternativesFDA package insert