Compare Omeprazole vs. Prevacid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prilosec
(omeprazole)

Prevacid
(lansoprazole)

Treats heartburn and stomach ulcers. Prilosec (Omeprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Treats heartburn and stomach ulcers. Prevacid (lansoprazole) is an effective and inexpensive acid reducer commonly used to provide heartburn relief and help heal ulcers.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.53Omeprazole
Reviews for Omeprazole
80%
of people (All ages) say Omeprazole is worth it
59%
say it works well
8%
say it's a big hassle
1167 reviews
Have you used Prilosec (omeprazole)?
Worth itNot sureNot worth it
Reviews for Prevacid
71%
+9% better vs. Omeprazole
71%
-12% worse vs. Omeprazole
19%
+11% better vs. Omeprazole
Have you used Prevacid (lansoprazole)?
Worth itNot sureNot worth it
Side effects
OmeprazolePrevacid
  • Upper respiratory infection 75%
  • Fever 33%
  • Headache 7%
  • Abdominal pain 5%
  • Nausea 4%
  • Diarrhea 4%
  • Accidental injuries 4%
  • Flatulence 3%
  • Vomiting 3%
More Omeprazole side effects »
  • Diarrhea 2%
  • Abdominal pain 1%
More Prevacid side effects »
How it works
OmeprazolePrevacid
Prilosec (Omeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Prevacid (lansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach by blocking the final step of stomach acid production.
Type of medication
OmeprazolePrevacid
Prescription or OTCPrescription or OTC
Available as
OmeprazolePrevacid
  • Extended release
  • Extended release
  • Dissolving tablet extended release
  • Liquid
Used for
OmeprazolePrevacid
Risk factors for serious side effects
OmeprazolePrevacid
  • Helicobacter pylori infection
  • Autoimmune disease
  • Being hospitalized
  • Antibiotic use
  • Osteoporosis
Detailed Prilosec (omeprazole) risks & warnings »
  • High dose Prevacid (lansoprazole)
  • Long-term treatment with Prevacid (lansoprazole)
  • Low bone mineral density
  • Older age
Detailed Prevacid (lansoprazole) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Price
OmeprazolePrevacid
No price related info.
  • Prevacid (lansoprazole) is available over-the-counter and as inexpensive, generic options.
Interactions
OmeprazolePrevacid
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
  • Some prescription drugs can interact with Prevacid (lansoprazole), so talk to your doctor or pharmacist about the medicines you are taking.
Food
OmeprazolePrevacid
  • Take 1 hour before a meal.
No food related info.
Kidneys and liver
OmeprazolePrevacid
No kidneys and liver related info.
  • Prevacid (lansoprazole) can cause acute kidney damage that can occur at any time during treatment. Stop taking Prevacid (lansoprazole) and speak to your doctor immediately if you notice blood in the urine, changes in urine output, swelling of the body, weight gain, fever, or confusion.
Upsides and benefits
OmeprazolePrevacid
  • Most people can take Omeprazole without any noticeable day-to-day side effects.
  • Omeprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Most people can take Prevacid (lansoprazole) without any noticeable day-to-day side effects.
  • Comes in a dissolving tablet to be placed on the tongue if you cannot or do not like to swallow pills.
  • Prevacid (lansoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Prevacid (lansoprazole) is available over-the-counter and as inexpensive, generic options.
Downsides and risks
OmeprazolePrevacid
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Omeprazole long-term.
  • Although the generic is affordable, other medications might still be cheaper than Omeprazole.
  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
  • Doesn't start working right away like some other acid reducers (Tums, Rolaids, or Maalox).
  • May not be the best choice for patients 65 years of age and older due to risk of bone fractures and C. diff infection (bacterial).
  • Is used if you have frequent heartburns that occur more than 2 days per week. Speak to your doctor or pharmacist if you only have occasional heartburn.
Tips from our pharmacists for people taking the medication
OmeprazolePrevacid
  • Take 1 hour before a meal.
  • Don't chew or crush capsules; swallow them whole.
  • If you have trouble swallowing you can carefully open the capsules and sprinkle the inside pellets onto applesauce. Swallow the applesauce without chewing or crushing the pellets.
  • When using Omeprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
  • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Omeprazole.
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
  • Take Prevacid (lansoprazole) with a full glass of water before eating.
  • Starts working in 1 to 3 hours. It can take 1 to 4 days to take full effect.
  • Some prescription drugs can interact with Prevacid (lansoprazole), so talk to your doctor or pharmacist about the medicines you are taking.
  • Do not take for more than 14 days, unless directed by your doctor. Speak to your doctor if your symptoms don't go away after 2 weeks.
  • Prevacid (lansoprazole) capsules can be opened and sprinkled on 1 tablespoon of applesauce, cottage cheese, or yogurt. Swallow immediately after. The dissolving tablets shouldn't be swallowed, broken, or chewed.
Learn more
More about OmeprazoleSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Prilosec (omeprazole)?
Worth itNot sureNot worth it
More about PrevacidSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Prevacid (lansoprazole)?
Worth itNot sureNot worth it