Compare Omeprazole vs. Rolaids

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prilosec
(Omeprazole)

Rolaids
(Calcium Carbonate / Magnesium Hydroxide)

Treats heartburn and stomach ulcers. Prilosec (Omeprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Relieves heartburn and acid tummy. Rolaids (Calcium Carbonate / Magnesium Hydroxide) gives quick relief for heartburn, but don't expect it to last all day.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.5411558669001755Omeprazole
Reviews for Prilosec (Omeprazole)
80%
of people say Prilosec (Omeprazole) is worth it
59%
say it works well
7%
say it's a big hassle
Reviews for Rolaids (Calcium Carbonate / Magnesium Hydroxide)
75%
5% vs. Prilosec (Omeprazole)
37%
22% vs. Prilosec (Omeprazole)
7%
Same vs. Prilosec (Omeprazole)
Side effects
OmeprazoleRolaids

The Omeprazole FDA package insert doesn’t have numbers about how common side effects are.

More about Omeprazole side effects »

We haven’t found good data for Rolaids side effects.

FDA side effect reports for Rolaids »
How it works
OmeprazoleRolaids
Prilosec (Omeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Rolaids (Calcium Carbonate / Magnesium Hydroxide) is an antacid. It counteracts the effects of stomach acid to relieve heartburn and acid tummy (indigestion).
Type of medication
OmeprazoleRolaids
Acid reducer
Proton pump inhibitor
Prescription or OTC
AntacidOver-the-counter
Available as
OmeprazoleRolaids
  • Extended release
  • Chewable tablet
  • Liquid
Used for (click to learn more)
OmeprazoleRolaids
Risk factors for serious side effects
OmeprazoleRolaids
    • Helicobacter pylori infection
    • Autoimmune disease
    • Being hospitalized
    • Antibiotic use
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
      Detailed Prilosec (Omeprazole) risks & warnings »
        • Current kidney disease
        • Kidney dialysis
        • Hyperparathyroid disease
        • Taking high doses of Vitamin D
        • Previous kidney stones
        Detailed Rolaids (Calcium Carbonate / Magnesium Hydroxide) risks & warnings »
        Pregnancy category
        OmeprazoleRolaids
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        NFDA pregnancy category (Unknown)

        The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.
        Food
        • Take 1 hour before a meal.
        No specific food-related info.
        Kidneys and liver
        No specific kidneys and liver-related info.
        • People with kidney disease on dialysis may need to take a lower dose or avoid use. Your doctor can do blood tests to see if it's safe to use.
        • If you have kidney or hyperparathyroid disease Rolaids (Calcium Carbonate / Magnesium Hydroxide) can build up in your blood. This may can cause toxic levels of calcium in your body. This is more likely if you have severe kidney disease (defined as a kidney function blood test called GFR of less than 30ml/min). If you have severe kidney disease or are on kidney dialysis don't use Rolaids (Calcium Carbonate / Magnesium Hydroxide); a different antacid would be better for you.
        • Rolaids (Calcium Carbonate / Magnesium Hydroxide) contains calcium. Calcium can be an ingredient in some kidney stones. If you have had kidney stones in the past (especially the calcium-containing kind) be careful using Rolaids (Calcium Carbonate / Magnesium Hydroxide). Use the lowest dose for the shortest time possible or just play it safe and use a different antacid instead.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        OmeprazoleRolaids
        • Most people can take Omeprazole without any noticeable day-to-day side effects.
        • Omeprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
        • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
        • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
        • Available as both a generic and over-the-counter option, so it's pretty affordable.
        • Works really fast.
        • Available over the counter without a prescription.
        • Cheap.
        Downsides and risks
        OmeprazoleRolaids
        • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
        • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
        • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Omeprazole long-term.
        • Although the generic is affordable, other medications might still be cheaper than Omeprazole.
        • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
        • Doesn't last very long.
        • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
        • Some chalky aftertaste.
        Tips from our pharmacists for people taking the medication
        OmeprazoleRolaids
        • Take 1 hour before a meal.
        • Don't chew or crush capsules; swallow them whole.
        • If you have trouble swallowing you can carefully open the capsules and sprinkle the inside pellets onto applesauce. Swallow the applesauce without chewing or crushing the pellets.
        • When using Omeprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
        • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Omeprazole.
        • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
        • Take at the first sign of discomfort.
        • You might need to take more than once a day but pay attention to the instructions on your bottle to avoid overdosing.
        • Take 1-2 hours apart from other medication that you take by mouth.
        • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
        • People with kidney disease on dialysis may need to take a lower dose or avoid use. Your doctor can do blood tests to see if it's safe to use.
        • Don't take if you have high blood calcium levels.
        Learn more
        More about OmeprazoleSide effectsReviews & ratingsAlternativesFDA package insert
        More about RolaidsSide effectsReviews & ratingsAlternativesFDA package insert