Compare Omeprazole vs. Tums

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prilosec
(omeprazole)

Tums
(calcium carbonate)

Treats heartburn and stomach ulcers. Prilosec (Omeprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Relieves heartburn. Tums (Calcium carbonate) gives quick relief for heartburn, but does not last all day. Talk to your doctor or pharmacist about other medicines if you need additional relief.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.53Omeprazole
Reviews for Omeprazole
80%
of people (All ages) say Omeprazole is worth it
59%
say it works well
8%
say it's a big hassle
1167 reviews
Have you used Prilosec (omeprazole)?
Worth itNot sureNot worth it
Reviews for Tums
82%
-2% worse vs. Omeprazole
43%
+16% better vs. Omeprazole
5%
-3% worse vs. Omeprazole
1373 reviews
Have you used Tums (calcium carbonate)?
Worth itNot sureNot worth it
Side effects
OmeprazoleTums
  • Upper respiratory infection 75%
  • Fever 33%
  • Headache 7%
  • Abdominal pain 5%
  • Nausea 4%
  • Diarrhea 4%
  • Accidental injuries 4%
  • Passing gas 3%
  • Vomiting 3%
More Omeprazole side effects »

We haven’t found good data for Tums side effects.

FDA side effect reports for Tums »
How it works
OmeprazoleTums
Prilosec (Omeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Tums (Calcium carbonate) is an antacid. It relieves heartburn and indigestion by neutralizing stomach acid.
Type of medication
OmeprazoleTums
Prescription or OTCOver-the-counter
Available as
OmeprazoleTums
  • Extended release
  • Chewable tablet
  • Liquid
Used for
OmeprazoleTums
Risk factors for serious side effects
OmeprazoleTums
  • Helicobacter pylori infection
  • Autoimmune disease
  • Being hospitalized
  • Antibiotic use
  • Osteoporosis
Detailed Prilosec (omeprazole) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Interactions
    OmeprazoleTums
    • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
    • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
    No interactions related info.
    Food
    OmeprazoleTums
    • Take 1 hour before a meal.
    No food related info.
    Kidneys and liver
    OmeprazoleTums
    No kidneys and liver related info.
    • May increase calcium levels too much in people with kidney or thyroid conditions.
    Upsides and benefits
    OmeprazoleTums
    • Most people can take Omeprazole without any noticeable day-to-day side effects.
    • Omeprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
    • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
    • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
    • Available as both a generic and over-the-counter option, so it's pretty affordable.
    • Tums (Calcium carbonate) is an effective, first-line medication for hearburn.
    • Tums (Calcium carbonate) starts working in seconds.
    • Has minimal side effects.
    • Available in chewable form.
    • Is inexpensive and readily available over-the-counter.
    • Coupons are available – speak to your doctor or pharmacist.
    Downsides and risks
    OmeprazoleTums
    • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
    • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
    • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Omeprazole long-term.
    • Although the generic is affordable, other medications might still be cheaper than Omeprazole.
    • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
    • Because Tums (Calcium carbonate) only lasts for 1 to 2 hours, you may need additional doses.
    • May increase calcium levels too much in people with kidney or thyroid conditions.
    • May have a chalky taste.
    Tips from our pharmacists for people taking the medication
    OmeprazoleTums
    • Take 1 hour before a meal.
    • Don't chew or crush capsules; swallow them whole.
    • If you have trouble swallowing you can carefully open the capsules and sprinkle the inside pellets onto applesauce. Swallow the applesauce without chewing or crushing the pellets.
    • When using Omeprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
    • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Omeprazole.
    • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
    • Take at the first sign of discomfort.
    • You may need to separate Tums (Calcium carbonate) from some medicines to avoid interactions. Talk to your doctor or pharmacist about all the medicines you're taking, including prescription, supplements, and over the counter medicines.
    • Eating smaller, more frequent meals can help alleviate some symptoms of heartburn.
    • Certain spicy or fatty foods increase your risk of heartburn. Talk to your doctor or pharmacist to find out which foods you should avoid.
    • Avoiding eating 3 hours before bedtime can also help prevent heartburn.
    • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
    Learn more
    More about OmeprazoleSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Prilosec (omeprazole)?
    Worth itNot sureNot worth it
    More about TumsSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Tums (calcium carbonate)?
    Worth itNot sureNot worth it