Compare Omeprazole vs. Tums

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prilosec (Omeprazole)

Prescription or OTC

Tums (Calcium carbonate)

Over-the-counter
Treats heartburn and stomach ulcers.

Prilosec (Omeprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.

5.5/ 7 average rating with 1167 reviewsforOmeprazole
Relieves heartburn.

Tums (Calcium carbonate) gives quick relief for heartburn, but does not last all day. Talk to your doctor or pharmacist about other medicines if you need additional relief.

5.2/ 7 average rating with 1373 reviewsforTums
Upsides
  • Most people can take Omeprazole without any noticeable day-to-day side effects.
  • Omeprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Tums (Calcium carbonate) is an effective, first-line medication for hearburn.
  • Tums (Calcium carbonate) starts working in seconds.
  • Has minimal side effects.
  • Available in chewable form.
  • Is inexpensive and readily available over-the-counter.
  • Coupons are available – speak to your doctor or pharmacist.
Downsides
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Omeprazole long-term.
  • Although the generic is affordable, other medications might still be cheaper than Omeprazole.
  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
  • Because Tums (Calcium carbonate) only lasts for 1 to 2 hours, you may need additional doses.
  • May increase calcium levels too much in people with kidney or thyroid conditions.
  • May have a chalky taste.
Used for
Dosage forms
  • Extended release
  • Chewable tablet
  • Liquid
Price
Lowest price near you
$4
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Reviews
1167 
80%
think this treatment is worth it
59%
think this treatment works well
8%
think this treatment is a hassle

Have you used Prilosec (Omeprazole)?

Leave a review
1373 
82%
think this treatment is worth it
43%
think this treatment works well
5%
think this treatment is a hassle

Have you used Tums (Calcium carbonate)?

Leave a review
Side effects
9possible side effects
  • Upper respiratory infection
    75%
  • Fever
    33%
  • Headache
    7%
  • Abdominal pain
    5%
  • Nausea
    4%
  • Diarrhea
    4%
  • Accidental injuries
    4%
  • Vomiting
    3%
  • Flatulence
    3%
See more detailed side effects
The Tums (Calcium carbonate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Severe stomach inflammation (atrophic gastritis)

    Helicobacter pylori infection

    ...and 1 more risk factors

  • Severe diarrhea

    Being hospitalized

    ...and 1 more risk factors

  • Broken bones

    Osteoporosis

    ...and 5 more risk factors

See more detailed risks and warnings
No information currently available