Compare Omeprazole vs. Zantac

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prilosec
(Omeprazole)

Zantac 75
(Ranitidine)

Treats heartburn and stomach ulcers. Prilosec (Omeprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Relieves heartburn. Zantac 75 (Ranitidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.5411558669001755Omeprazole
Reviews for Prilosec (Omeprazole)
80%
of people (All ages) say Prilosec (Omeprazole) is worth it
59%
say it works well
7%
say it's a big hassle
1142 reviews
Have you used Prilosec (Omeprazole)?
Worth itNot sureNot worth it
Reviews for Zantac 75 (Ranitidine)
72%
8% vs. Prilosec (Omeprazole)
43%
16% vs. Prilosec (Omeprazole)
7%
Same vs. Prilosec (Omeprazole)
1049 reviews
Have you used Zantac 75 (Ranitidine)?
Worth itNot sureNot worth it
Side effects
OmeprazoleZantac

The Omeprazole FDA package insert doesn’t have numbers about how common side effects are.

More about Omeprazole side effects »

The Zantac FDA package insert doesn’t have numbers about how common side effects are.

More about Zantac side effects »
How it works
OmeprazoleZantac
Prilosec (Omeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Zantac 75 (Ranitidine) is an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
OmeprazoleZantac
Acid reducer
Proton pump inhibitor
Prescription or OTC
Acid reducer
Histamine blocker
Prescription or OTC
Available as
OmeprazoleZantac
  • Extended release
  • Pill
  • Oral solution
  • Injection
Used for (click to learn more)
OmeprazoleZantac
Risk factors for serious side effects
OmeprazoleZantac
    • Helicobacter pylori infection
    • Autoimmune disease
    • Being hospitalized
    • Antibiotic use
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
      Detailed Prilosec (Omeprazole) risks & warnings »
        • Current kidney problems
        • Current liver problems
        • Acute Porphyria
        • History of Phenylketonuria (PKU)
        Detailed Zantac 75 (Ranitidine) risks & warnings »
        Pregnancy

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Interactions
        OmeprazoleZantac
        • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
        • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
        • Few drug interactions.
        Food
        OmeprazoleZantac
        • Take 1 hour before a meal.
        No food related info.
        Kidneys and liver
        OmeprazoleZantac
        No kidneys and liver related info.
        • People with kidney disease may need to take a lower dose.
        • Zantac 75 (Ranitidine) is processed by the kidney and liver. If you have kidney or liver problems, you may need a different dose to prevent this increased risk for side effects.
        Upsides and benefits
        OmeprazoleZantac
        • Most people can take Omeprazole without any noticeable day-to-day side effects.
        • Omeprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
        • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
        • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
        • Available as both a generic and over-the-counter option, so it's pretty affordable.
        • Most people can take Ranitidine without any noticeable day-to-day side effects.
        • Ranitidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
        • Few drug interactions.
        • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
        • Available as both a generic and over-the-counter option, so it's pretty affordable.
        Downsides and risks
        OmeprazoleZantac
        • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
        • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
        • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Omeprazole long-term.
        • Although the generic is affordable, other medications might still be cheaper than Omeprazole.
        • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
        • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Ranitidine.
        • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Ranitidine (H2 blockers).
        Tips from our pharmacists for people taking the medication
        OmeprazoleZantac
        • Take 1 hour before a meal.
        • Don't chew or crush capsules; swallow them whole.
        • If you have trouble swallowing you can carefully open the capsules and sprinkle the inside pellets onto applesauce. Swallow the applesauce without chewing or crushing the pellets.
        • When using Omeprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
        • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Omeprazole.
        • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
        • Works best if you take it with a full glass of water.
        • Starts working in one hour.
        • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
        • People with kidney disease may need to take a lower dose.
        Learn more
        More about OmeprazoleSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Prilosec (Omeprazole)?
        Worth itNot sureNot worth it
        More about ZantacSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Zantac 75 (Ranitidine)?
        Worth itNot sureNot worth it