Compare Onglyza vs. Byetta

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Onglyza
(saxagliptin)

Byetta
(exenatide)

Lowers blood sugar. Onglyza (saxagliptin) can cause heart failure unlike other medicines that work just like it.Lowers blood sugar. Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.
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Coupons for Onglyza
Best available price for 30 (5mg) tablets of onglyza
Coupons for Byetta
Best available price for 2.4 (10mcg) pens of byetta
Reviews & ratings
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Have you used Onglyza (saxagliptin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Byetta (exenatide)?
Worth itNot sureNot worth it
Side effects
OnglyzaByetta
  • Urinary tract infection 1%
  • Headache 1%
  • Swelling in arms and legs 4%
  • Low blood sugar (hypoglycemia) 2%
  • Allergic reactions 2%
More Onglyza side effects »
  • Low blood sugar 11%
  • Nausea 33%
  • Diarrhea 10%
  • Vomiting 14%
  • Headache 10%
  • Constipation 8%
  • Indigestion 5%
  • Weakness 4%
  • Abdominal swelling 3%
  • Loss of appetite 3%
More Byetta side effects »
How it works
OnglyzaByetta
Onglyza (saxagliptin) is an anti-diabetic drug. It lowers your blood sugar by enhancing your body's release of insulin.Byetta (Exenatide) enhances the release of insulin in your gut and pancreas to lower your blood sugar.
Type of medication
OnglyzaByetta
Prescription onlyPrescription only
Available as
OnglyzaByetta
  • Pill
  • Injection
Used for
OnglyzaByetta
Risk factors for serious side effects
OnglyzaByetta
  • Alcoholism
  • Elevated triglycerides
  • History of pancreatitis
  • Gallstones
  • History of heart failure
Detailed Onglyza (saxagliptin) risks & warnings »
  • Severe renal impairment
  • End-stage renal disease
  • Severe gastrointestinal disease
  • Gastroparesis
Detailed Byetta (exenatide) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
OnglyzaByetta
  • Certain drugs may interact with Onglyza (saxagliptin), let your doctor know all the medications you are currently taking and before starting Onglyza (saxagliptin).
No interactions related info.
Kidneys and liver
OnglyzaByetta
  • May be a good option for those with bad liver function.
  • If you have severe kidney or liver problems, you should not take Byetta (Exenatide). Talk to your doctor about testing your kidneys before starting Byetta (Exenatide). People taking medications that are damaging to kidneys such as ACE inhibitors, NSAIDs or diuretics in addition to Byetta (Exenatide) may notice nausea, vomiting, or diarrhea.
Pain
OnglyzaByetta
No pain related info.
  • Using Byetta (Exenatide) has been associated with stomach pain, nausea, vomiting and diarrhea. If you have severe gastrointestinal disease such as Crohn’s Disease or Ulcerative Colitis, you should talk to your doctor about using a different medicine for diabetes. You should not use Byetta (Exenatide) if you have gastroparesis, a condition that causes slow or irregular digestion. Gastroparesis can be common for people that have had uncontrolled diabetes for a while.
Weight
OnglyzaByetta
  • Does not cause weight gain.
No weight related info.
Upsides and benefits
OnglyzaByetta
  • DRUG-NAME is an oral blood sugar lowering medicine. It's a good option if you don't like injections.
  • Does not cause weight gain.
  • May be a good option for those with bad liver function.
  • Does not cause hypoglycemia (low blood sugar) when taken by itself.
  • Can lower your A1c (average blood sugar over time) by 1%.
  • Not as likely to cause very low blood sugar as glyburine or insulin.
  • Does not increase your appetite like other anti-diabetic medicines.
  • Pen is dialed to a single dose for easy injections.
Downsides and risks
OnglyzaByetta
  • Typically not first-choice treatment for diabetes.
  • Only lowers A1C (average blood sugar over time) by ~0.5%.
  • Risk for heart failure has not been seen in other medicines that work just like it.
  • May be more expensive than other anti-diabetic medicines.
  • Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
  • It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
  • Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
Tips from our pharmacists for people taking the medication
OnglyzaByetta
  • Is taken once daily.
  • Certain drugs may interact with Onglyza (saxagliptin), let your doctor know all the medications you are currently taking and before starting Onglyza (saxagliptin).
  • Stop taking Onglyza (saxagliptin) and see your doctor immediately if you experience severe stomach pain that does not go away, as this may indicate dangerous inflammation of the pancreas.
  • Maintain a consistent diet and exercise regimen to prevent low blood sugar or high blood sugar.
  • Inject into your belly, thighs, or upper arms within an hour of your main meals.
  • Store unused pens in the refrigerator.
  • After first use, pens can be kept at room temperature for 30 days.
  • Change the needle and prime the pen every time you inject.
  • If you're also on insulin, don't inject into the same site.
  • Best to check your blood sugar once a day to make sure your medicine is working properly.
Learn more
More about OnglyzaSide effectsAlternativesFDA package insert
Have you used Onglyza (saxagliptin)?
Worth itNot sureNot worth it
More about ByettaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Byetta (exenatide)?
Worth itNot sureNot worth it