Compare Onglyza vs. glyburide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Onglyza
(saxagliptin)

Diabeta
(glyburide)

Lowers blood sugar. Onglyza (saxagliptin) can cause heart failure unlike other medicines that work just like it.Lowers blood sugar. Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.
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Coupons for Onglyza
Best available price for 30 (5mg) tablets of onglyza
Coupons for glyburide
Best available price for 60 (5mg) tablets of glyburide
Reviews & ratings
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Have you used Onglyza (saxagliptin)?
Worth itNot sureNot worth it
Reviews for glyburide
45%
-45% worse vs. Onglyza
34%
-34% worse vs. Onglyza
21%
+21% better vs. Onglyza
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Side effects
Onglyzaglyburide
  • Urinary tract infection 1%
  • Headache 1%
  • Swelling in arms and legs 4%
  • Low blood sugar (hypoglycemia) 2%
  • Allergic reactions 2%
More Onglyza side effects »
  • Nausea and heartburn 2%
  • Skin allergies 2%
More glyburide side effects »
How it works
Onglyzaglyburide
Onglyza (saxagliptin) is an anti-diabetic drug. It lowers your blood sugar by enhancing your body's release of insulin.Diabeta (glyburide) stimulates your body to release insulin and lower blood sugar.
Type of medication
Onglyzaglyburide
Prescription onlyPrescription only
Available as
Onglyzaglyburide
  • Pill
  • Pill
Used for
Onglyzaglyburide
Risk factors for serious side effects
Onglyzaglyburide
  • Alcoholism
  • Elevated triglycerides
  • History of pancreatitis
  • Gallstones
  • History of heart failure
Detailed Onglyza (saxagliptin) risks & warnings »
  • Over age 65
  • Kidney problems
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
Detailed Diabeta (glyburide) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
Onglyzaglyburide
  • Certain drugs may interact with Onglyza (saxagliptin), let your doctor know all the medications you are currently taking and before starting Onglyza (saxagliptin).
No interactions related info.
Alcohol
Onglyzaglyburide
No alcohol related info.
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
Food
Onglyzaglyburide
No food related info.
  • Eat well-balanced meals to avoid low blood sugar.
Kidneys and liver
Onglyzaglyburide
  • May be a good option for those with bad liver function.
  • Not ideal for elderly or those with poor kidney function.
Weight
Onglyzaglyburide
  • Does not cause weight gain.
  • Can cause weight gain, dizziness, or stomach upset.
  • Can cause weight gain (about 2 to 3 pounds).
Upsides and benefits
Onglyzaglyburide
  • DRUG-NAME is an oral blood sugar lowering medicine. It's a good option if you don't like injections.
  • Does not cause weight gain.
  • May be a good option for those with bad liver function.
  • Does not cause hypoglycemia (low blood sugar) when taken by itself.
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
Downsides and risks
Onglyzaglyburide
  • Typically not first-choice treatment for diabetes.
  • Only lowers A1C (average blood sugar over time) by ~0.5%.
  • Risk for heart failure has not been seen in other medicines that work just like it.
  • May be more expensive than other anti-diabetic medicines.
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
Tips from our pharmacists for people taking the medication
Onglyzaglyburide
  • Is taken once daily.
  • Certain drugs may interact with Onglyza (saxagliptin), let your doctor know all the medications you are currently taking and before starting Onglyza (saxagliptin).
  • Stop taking Onglyza (saxagliptin) and see your doctor immediately if you experience severe stomach pain that does not go away, as this may indicate dangerous inflammation of the pancreas.
  • Maintain a consistent diet and exercise regimen to prevent low blood sugar or high blood sugar.
  • Check your blood sugar regularly.
  • Eat well-balanced meals to avoid low blood sugar.
  • Works best if you take it 30 minutes before first main meal of the day.
  • Can cause weight gain, dizziness, or stomach upset.
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
Learn more
More about OnglyzaSide effectsAlternativesFDA package insert
Have you used Onglyza (saxagliptin)?
Worth itNot sureNot worth it
More about glyburideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it