Compare Onglyza vs. glyburide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Onglyza (saxagliptin)

Prescription only

Diabeta (glyburide)

Prescription only
Lowers blood sugar.

Onglyza (saxagliptin) can cause heart failure unlike other medicines that work just like it.

Lowers blood sugar.

Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.

4.4/ 7 average rating with 110 reviewsforglyburide
Upsides
  • DRUG-NAME is an oral blood sugar lowering medicine. It's a good option if you don't like injections.
  • Does not cause weight gain.
  • May be a good option for those with bad liver function.
  • Does not cause hypoglycemia (low blood sugar) when taken by itself.
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
Downsides
  • Typically not first-choice treatment for diabetes.
  • Only lowers A1C (average blood sugar over time) by ~0.5%.
  • Risk for heart failure has not been seen in other medicines that work just like it.
  • May be more expensive than other anti-diabetic medicines.
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price near you
$402.35
Find instant savings
Lowest price near you
$10
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
Not enough review data.Leave a review
110 
45%
think this treatment is worth it
34%
think this treatment works well
21%
think this treatment is a hassle

Have you used Diabeta (glyburide)?

Leave a review
Side effects
The Onglyza (saxagliptin) FDA package insert doesn’t have numbers about how common side effects are.
The Diabeta (glyburide) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • inflammation of the pancreas

    Alcoholism

    ...and 3 more risk factors

  • Heart failure

    History of heart failure

    ...and 1 more risk factors

  • Low blood sugar (hypoglycemia)

    Alcohol

    ...and 3 more risk factors

See more detailed risks and warnings
  • Low blood sugar

    Over age 65

    ...and 4 more risk factors

  • Severe allergic reactions

    History of sulfa allergies

See more detailed risks and warnings