Compare Onglyza vs. Nesina

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Onglyza (saxagliptin)

Prescription only
Lowers blood sugar.

Onglyza (saxagliptin) can cause heart failure unlike other medicines that work just like it.

Lowers your blood sugar.

alogliptin is a good add-on treatment if your blood sugar is still too high, but you don't want to use an injectable medicine.

Upsides
  • DRUG-NAME is an oral blood sugar lowering medicine. It's a good option if you don't like injections.
  • Does not cause weight gain.
  • May be a good option for those with bad liver function.
  • Does not cause hypoglycemia (low blood sugar) when taken by itself.
  • Oral blood sugar-lowering medicine.
  • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
  • Rarely causes low blood sugar.
  • Patients taking alogliptin had less cold symptoms than patients taking Januvia.
Downsides
  • Typically not first-choice treatment for diabetes.
  • Only lowers A1C (average blood sugar over time) by ~0.5%.
  • Risk for heart failure has not been seen in other medicines that work just like it.
  • May be more expensive than other anti-diabetic medicines.
  • Not as strong as other diabetes medicines. Your doctor might add it to your blood sugar-lowering regimen if your sugar levels are still too high.
  • Likely expensive since there's no generic version available.
  • Some people might get frequent throat infections or nasal congestion.
Used for
  • Diabetes mellitus type 2
Dosage forms
  • Pill
  • Pill
Price
Lowest price near you
$402.35
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Lowest price near you
$94.57
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Side effects
The Onglyza (saxagliptin) FDA package insert doesn’t have numbers about how common side effects are.
The Nesina (Alogliptin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • inflammation of the pancreas

    Alcoholism

    ...and 3 more risk factors

  • Heart failure

    History of heart failure

    ...and 1 more risk factors

  • Low blood sugar (hypoglycemia)

    Alcohol

    ...and 3 more risk factors

See more detailed risks and warnings