Compare Onglyza vs. Nesina

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Onglyza
(saxagliptin)

Nesina
(alogliptin)

Lowers blood sugar. Onglyza (saxagliptin) can cause heart failure unlike other medicines that work just like it.Lowers your blood sugar. alogliptin is a good add-on treatment if your blood sugar is still too high, but you don't want to use an injectable medicine.
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Coupons for Onglyza
Best available price for 30 (5mg) tablets of onglyza
Coupons for Nesina
Best available price for 30 (25mg) tablets of alogliptin
Reviews & ratings
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Have you used Onglyza (saxagliptin)?
Worth itNot sureNot worth it

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Have you used Nesina (alogliptin)?
Worth itNot sureNot worth it
Side effects
OnglyzaNesina
  • Urinary tract infection 1%
  • Headache 1%
  • Swelling in arms and legs 4%
  • Low blood sugar (hypoglycemia) 2%
  • Allergic reactions 2%
More Onglyza side effects »

We haven’t found good data for Nesina side effects.

FDA side effect reports for Nesina »
How it works
OnglyzaNesina
Onglyza (saxagliptin) is an anti-diabetic drug. It lowers your blood sugar by enhancing your body's release of insulin.alogliptin is an anti-diabetic drug. It improves your body's ability to use insulin to lower your blood sugar.
Type of medication
OnglyzaNesina
Prescription only
Available as
OnglyzaNesina
  • Pill
  • Pill
Used for
OnglyzaNesina
  • Diabetes Mellitus Type 2
Risk factors for serious side effects
OnglyzaNesina
  • Alcoholism
  • Elevated triglycerides
  • History of pancreatitis
  • Gallstones
  • History of heart failure
Detailed Onglyza (saxagliptin) risks & warnings »
    Detailed Nesina (alogliptin) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Interactions
    OnglyzaNesina
    • Certain drugs may interact with Onglyza (saxagliptin), let your doctor know all the medications you are currently taking and before starting Onglyza (saxagliptin).
    No interactions related info.
    Kidneys and liver
    OnglyzaNesina
    • May be a good option for those with bad liver function.
    No kidneys and liver related info.
    Weight
    OnglyzaNesina
    • Does not cause weight gain.
    No weight related info.
    Upsides and benefits
    OnglyzaNesina
    • DRUG-NAME is an oral blood sugar lowering medicine. It's a good option if you don't like injections.
    • Does not cause weight gain.
    • May be a good option for those with bad liver function.
    • Does not cause hypoglycemia (low blood sugar) when taken by itself.
    • Oral blood sugar-lowering medicine.
    • Lowers A1c levels by around 1%. (Hemoglobin A1c measures your average blood sugar over time.)
    • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
    • Rarely causes low blood sugar.
    • Patients taking alogliptin had less cold symptoms than patients taking Januvia.
    Downsides and risks
    OnglyzaNesina
    • Typically not first-choice treatment for diabetes.
    • Only lowers A1C (average blood sugar over time) by ~0.5%.
    • Risk for heart failure has not been seen in other medicines that work just like it.
    • May be more expensive than other anti-diabetic medicines.
    • Not as strong as other diabetes medicines. Your doctor might add it to your blood sugar-lowering regimen if your sugar levels are still too high.
    • Likely expensive since there's no generic version available.
    • Some people might get frequent throat infections or nasal congestion.
    Tips from our pharmacists for people taking the medication
    OnglyzaNesina
    • Is taken once daily.
    • Certain drugs may interact with Onglyza (saxagliptin), let your doctor know all the medications you are currently taking and before starting Onglyza (saxagliptin).
    • Stop taking Onglyza (saxagliptin) and see your doctor immediately if you experience severe stomach pain that does not go away, as this may indicate dangerous inflammation of the pancreas.
    • Maintain a consistent diet and exercise regimen to prevent low blood sugar or high blood sugar.
    • Can cause headache and cold-like symptoms.
    • Tell your doctor about any mental confusion, persistent abdominal pain, dark urine, yellowing of eyes/skin, or easy bruising.
    • Can be expensive depending on insurance coverage.
    • Check your blood sugar regularly.
    Learn more
    More about OnglyzaSide effectsAlternativesFDA package insert
    Have you used Onglyza (saxagliptin)?
    Worth itNot sureNot worth it
    More about NesinaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Nesina (alogliptin)?
    Worth itNot sureNot worth it