Compare Onzetra vs. Frova

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Onzetra
(sumatriptan)

Frova
(frovatriptan)

Treats migraine headaches. Onzetra (sumatriptan) is the only medicine that's available in a breath-powered nose powder to treat migraines. However, it can be expensive compared to other medicines.Treats migraine headaches. Triptans are the first-choice to treat migraines. Frova (frovatriptan) works just as well as other triptans for migraines, but doesn't work for other types of headaches like cluster headaches.
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Coupons for Onzetra
Best available price for 1 (9 tablets of 100mg) dose pack of sumatriptan
Coupons for Frova
Best available price for 1 (9 tablets of 2.5mg) dose pack of frovatriptan
Reviews & ratings
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Reviews for Onzetra (sumatriptan)
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of people (All ages) say Onzetra (sumatriptan) is worth it
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say it works well
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say it's a big hassle
Have you used Onzetra (sumatriptan)?
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Reviews for Frova (frovatriptan)
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Same vs. Onzetra (sumatriptan)
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Same vs. Onzetra (sumatriptan)
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Same vs. Onzetra (sumatriptan)
Have you used Frova (frovatriptan)?
Worth itNot sureNot worth it
Side effects
OnzetraFrova
  • Changes in taste 17%
  • Discomfort in the nose 10%
  • Runny nose 3%
  • Stuffy nose 2%
More Onzetra side effects »
  • Dizziness 3%
  • Fatigue 3%
  • Headache 1%
  • Tingling or prickling sensation 2%
  • Flushing 2%
  • Dry mouth 2%
  • Hot or cold sensation 1%
  • Muscle pain 1%
  • Indigestion 1%
  • Chest pain 1%
More Frova side effects »
How it works
OnzetraFrova
Onzetra (sumatriptan) is a selective serotonin receptor agonist called a triptan. It's believed that migraine headaches happen when blood vessels are too open and allow too much blood in the brain. Onzetra (sumatriptan) tightens the blood vessels, which relieves the pain.Frova (frovatriptan) is a triptan. It prevents the opening of blood vessels in your brain, which causes migraines.
Type of medication
OnzetraFrova
Prescription only
Prescription only
Available as
OnzetraFrova
  • Nasal powder
  • Pill
Used for
OnzetraFrova
Risk factors for serious side effects
OnzetraFrova
  • Heart disease
  • History of chest pain
  • Uncontrolled high blood pressure
  • History of a stroke
  • Using Onzetra (sumatriptan) for more than 10 days a month
Detailed Onzetra (sumatriptan) risks & warnings »
  • Heart disease
  • history of chest pain/angina
  • uncontrolled high blood pressure
  • History of a stroke
  • Using Frova (frovatriptan) for more than 2 to 3 days a week or 10 days a month
Detailed Frova (frovatriptan) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Sleep
OnzetraFrova
No sleep related info.
  • Frova (frovatriptan) can make you dizzy or sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
Upsides and benefits
OnzetraFrova
  • Compared to pills, Onzetra (sumatriptan) is better absorbed in the body and good if it's hard to take pills.
  • Onzetra (sumatriptan) is a first choice medicine to treat migraines.
  • There is a copay program available that can make Onzetra (sumatriptan) cheaper.
  • Frova (frovatriptan) is available in generic.
  • Unlike other similar medicines, you can take up to 3 tablets of Frova (frovatriptan) every 24 hours.
  • Frova (frovatriptan) is first choice of medicines for treatment of migraine headaches.
Downsides and risks
OnzetraFrova
  • It can be very expensive. There are other forms of this same medicine that are much cheaper, including a nose spray.
  • You have to use two nosepieces to get the full dose of Onzetra (sumatriptan), which can be hard to remember.
  • Onzetra (sumatriptan) is only available in one strength.
  • Available as an oral tablet only, which may be difficult to swallow during bad migraine attack.
  • Doesn't prevent migraines.
  • Doesn't work for other types of headaches like cluster headaches.
  • Not recommended for children under 18 years old.
Tips from our pharmacists for people taking the medication
OnzetraFrova
  • Follow the instructions exactly as shown by the package insert and your doctor or pharmacist; otherwise, Onzetra (sumatriptan) won't work correctly and you won't get any medicine.
  • Onzetra (sumatriptan) can only treat a migraine that's already happening. You can't use it to stop migraines from starting.
  • You have to use 2 nosepieces of Onzetra (sumatriptan) to get the full dose of medicine.
  • Don't use more than 2 full doses (4 nosepieces) in a 24-hour period.
  • If you're using more than 8 doses of Onzetra (sumatriptan) a month, talk to your doctor to see if you should try another medicine.
  • You can only use each nosepiece of Onzetra (sumatriptan) once. Throw it away in the trash after you've checked that you used the medicine correctly.
  • Doesn't prevent migraines.
  • Use as soon as you feel a migraine starting. You can take another dose 2 hours later, but don't take more than 3 tablets in 24 hours.
  • Don't use it excessively since it can cause you to have more headaches. Talk to your doctor if you are having more than 4 migraines in a month.
  • Frova (frovatriptan) can make you dizzy or sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Frova (frovatriptan) can cause nausea or tightness in the chest or throat. Talk to your doctor if it bothers you.
Learn more
More about OnzetraSide effectsAlternativesFDA package insert
Have you used Onzetra (sumatriptan)?
Worth itNot sureNot worth it
More about FrovaSide effectsAlternativesFDA package insert
Have you used Frova (frovatriptan)?
Worth itNot sureNot worth it