Compare Onzetra vs. Imitrex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Onzetra
(sumatriptan)

Imitrex
(Sumatriptan)

Treats migraine headaches. Onzetra (sumatriptan) is the only medicine that's available in a breath-powered nose powder to treat migraines. However, it can be expensive compared to other medicines.Treats migraine headaches. Imitrex (Sumatriptan) is an excellent choice for acute migraine relief, but you might need another medication to prevent headaches.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Onzetra (sumatriptan)?
Worth itNot sureNot worth it
Reviews for Imitrex
74%
-74% worse vs. Onzetra
68%
-68% worse vs. Onzetra
19%
+19% better vs. Onzetra
Have you used Imitrex (Sumatriptan)?
Worth itNot sureNot worth it
Side effects
OnzetraImitrex
  • Stuffy nose 2%
  • Runny nose 3%
  • Discomfort in the nose 10%
  • Changes in taste 17%
More Onzetra side effects »
  • Pain - location specified 1%
  • Malaise/fatigue 2%
  • Paresthesia (all types) 1%
  • Sensation warm/cold 1%
  • Atypical sensations 1%
  • Pain and other pressure sensations 2%
  • Chest - pain/tightness/pressure and/or heaviness 1%
  • Neck/throat/jaw - pain/ tightness/pressure 2%
  • Vertigo 2%
  • Other - pressure/tightness/ heaviness 1%
More Imitrex side effects »
How it works
OnzetraImitrex
Onzetra (sumatriptan) is a selective serotonin receptor agonist called a triptan. It's believed that migraine headaches happen when blood vessels are too open and allow too much blood in the brain. Onzetra (sumatriptan) tightens the blood vessels, which relieves the pain.Imitrex (Sumatriptan) is a triptan medication that treats migraine headaches. It releases serotonin, which lowers the inflammation that causes headaches.
Type of medication
OnzetraImitrex
Prescription onlyNo lower cost generic availablePrescription onlyLower-cost generic available
Available as
OnzetraImitrex
  • Nasal powder
  • Pill
  • Injection
  • Nasal spray
Used for
OnzetraImitrex
Risk factors for serious side effects
OnzetraImitrex
  • Heart disease
  • History of chest pain
  • Uncontrolled high blood pressure
  • History of a stroke
  • Using Onzetra (sumatriptan) for more than 10 days a month
Detailed Onzetra (sumatriptan) risks & warnings »
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
Detailed Imitrex (Sumatriptan) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Sleep
OnzetraImitrex
No sleep related info.
  • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
Upsides and benefits
OnzetraImitrex
  • Compared to pills, Onzetra (sumatriptan) is better absorbed in the body and good if it's hard to take pills.
  • Onzetra (sumatriptan) is a first choice medicine to treat migraines.
  • There is a copay program available that can make Onzetra (sumatriptan) cheaper.
  • Comes in several forms. Ask your doctor if you should use the pill, nasal spray, patch, or injection.
  • A combination of forms can be used if symptoms do not improve.
  • The nasal spray and injectable forms work very quickly.
  • It's generally safe to use if you are pregnant.
  • Comes in a generic form, so it can be pretty cheap.
Downsides and risks
OnzetraImitrex
  • It can be very expensive. There are other forms of this same medicine that are much cheaper, including a nose spray.
  • You have to use two nosepieces to get the full dose of Onzetra (sumatriptan), which can be hard to remember.
  • Onzetra (sumatriptan) is only available in one strength.
  • The oral and nasal versions of Imitrex (Sumatriptan) have an unpleasant after-taste.
  • Does not prevent migraine headaches; it only treats them once they start.
  • Must wait 1 hour before using second injection.
  • Can cause rebound (more) headaches if Imitrex (Sumatriptan) is used too often.
  • Need to have your blood pressure checked often, especially if you're pregnant.
Tips from our pharmacists for people taking the medication
OnzetraImitrex
  • Follow the instructions exactly as shown by the package insert and your doctor or pharmacist; otherwise, Onzetra (sumatriptan) won't work correctly and you won't get any medicine.
  • Onzetra (sumatriptan) can only treat a migraine that's already happening. You can't use it to stop migraines from starting.
  • You have to use 2 nosepieces of Onzetra (sumatriptan) to get the full dose of medicine.
  • Don't use more than 2 full doses (4 nosepieces) in a 24-hour period.
  • If you're using more than 8 doses of Onzetra (sumatriptan) a month, talk to your doctor to see if you should try another medicine.
  • You can only use each nosepiece of Onzetra (sumatriptan) once. Throw it away in the trash after you've checked that you used the medicine correctly.
  • Take it as soon as your headache starts.
  • If you use the nasal spray, be sure to blow your nose before using it.
  • If you use the patch, put it on a dry area free of scars, tattoos, or other cuts and scrapes. Be sure to press the button to activate it.
  • If you use the injection, you can use a second injection if you still have a headache after an hour. If you have symptoms 2 hours after the injection, switch to the pill version.
  • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
  • Lie down in a dark room after taking Imitrex (Sumatriptan) to help ease the pain.
Learn more
More about OnzetraSide effectsAlternativesFDA package insert
Have you used Onzetra (sumatriptan)?
Worth itNot sureNot worth it
More about ImitrexSide effectsReviews & ratingsFDA package insert
Have you used Imitrex (Sumatriptan)?
Worth itNot sureNot worth it