Compare Orencia vs. Arava

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Orencia
(abatacept)

Arava
(leflunomide)

Calms down the immune system and prevents joint damage. Orencia (abatacept) slows the progress of rheumatoid arthritis, but can also cause serious side effects.Coming soon.
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Coupons for Orencia
Best available price for 4 (4 syringes of 125mg/ml) cartons of orencia
Coupons for Arava
Best available price for 30 (20mg) tablets of arava
Reviews & ratings
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Have you used Orencia (abatacept)?
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Have you used Arava (leflunomide)?
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Side effects
OrenciaArava
  • Headache 5%
  • Common cold 3%
  • Dizziness 2%
  • Cough 1%
  • Back pain 1%
  • High blood pressure 3%
  • Indigestion 2%
  • Urinary tract infection 1%
  • Rash 1%
  • Pain in arms or legs 1%
More Orencia side effects »

We haven’t found good data for Arava side effects.

FDA side effect reports for Arava »
How it works
OrenciaArava
Orencia (abatacept) is a biologic DMARD (disease-modifying anti-rheumatic drug) - sometimes just called a "biologic". It prevents your body from activating the cells that cause inflammation.Coming soon.
Type of medication
OrenciaArava
Prescription only
Available as
OrenciaArava
  • Infusion
  • Injection
  • Pill
Used for
OrenciaArava
  • Rheumatoid Arthritis
Risk factors for serious side effects
OrenciaArava
  • Using TNF inhibitors
  • Taking immunosuppressive medications
  • History of repeat infections
  • Adults with rheumatoid arthritis taking TNF inhibitors
  • COPD
Detailed Orencia (abatacept) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Upsides and benefits
    OrenciaArava
    • In a 2-year study that used IV Orencia (abatacept) with methotrexate, more than half of the people had remission and the majority felt significantly better.
    • Helps minimize joint damage, lowers symptoms, and prevents future problems. People taking Orencia (abatacept) had no new joint damage after two years.
    • Taking Orencia (abatacept) allows RA patients to use less prednisone, a steroid that has many side effects.
    • You can give yourself Orencia (abatacept) subcutaneously on your own at home rather than visiting a clinic or hospital.
    • Available in a prefilled autoinjector for convenient use.
    Coming soon
    Downsides and risks
    OrenciaArava
    • Orencia (abatacept) can be costly.
    • The IV infusion form of Orencia (abatacept) can cause a reaction, which ranges from a slight itching or warm feeling to more serious side effects such as low blood pressure and chest pain.
    • The IV infusion form of Orencia (abatacept) contains maltose, a type of sugar, that can give false high blood sugar readings with certain types of blood sugar monitors on the day of Orencia (abatacept) infusion. The self-injection subcutaneous form does not contain maltose. Talk to your doctor if you have diabetes.
    • If you need TNF inhibitors as part of your treatment, it is not recommended to take Orencia (abatacept). If you have COPD, you are at higher risk of side effects.
    • Orencia (abatacept) lowers your ability to fight infection. Your risk can increase if you take medications that lower your immune system or have an active infection. You may need to get tested for tuberculosis before starting Orencia (abatacept).
    Coming soon
    Tips from our pharmacists for people taking the medication
    OrenciaArava
    • If you are using the IV version of Orencia (abatacept), you will only need to get infusions once a month (after the first initial doses). It takes about 30 minutes to give the full dose of medicine. Stay hydrated and ask your nurse to apply dry heat (instant warm packs) to your arm to help find your good veins.
    • The self-injections are taken once a week. You or your caregiver should receive training on the proper way to prepare and inject Orencia (abatacept).
    • Keep the Orencia (abatacept) self-injection refrigerated, and let it rest at room temperature for 30 minutes before using it.
    • Each time you use Orencia (abatacept), it's important to rotate the sites you chose to inject it in. Don't inject Orencia (abatacept) into skin that's red, bruised, or irritated.
    • Talk with your doctor before getting any vaccines. Use of this drug may either raise the chance of an infection or make the vaccine not work as well.
    • As with all injection medicines, store it securely away from children and throw away used syringes in an FDA-approved sharps disposal container, never in the trash.
    Coming soon
    Learn more
    More about OrenciaSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Orencia (abatacept)?
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    More about AravaSide effectsReviews & ratingsFDA package insert
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