Compare Orencia vs. Humira

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Orencia (abatacept)

Prescription only

Humira (adalimumab)

Prescription only
Calms down the immune system and prevents joint damage.

Orencia (abatacept) slows the progress of rheumatoid arthritis, but can also cause serious side effects.

Calms down the immune system.

Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.

4.9/ 7 average rating with 182 reviewsforHumira
Upsides
  • In a 2-year study that used IV Orencia (abatacept) with methotrexate, more than half of the people had remission and the majority felt significantly better.
  • Helps minimize joint damage, lowers symptoms, and prevents future problems. People taking Orencia (abatacept) had no new joint damage after two years.
  • Taking Orencia (abatacept) allows RA patients to use less prednisone, a steroid that has many side effects.
  • You can give yourself Orencia (abatacept) subcutaneously on your own at home rather than visiting a clinic or hospital.
  • Available in a prefilled autoinjector for convenient use.
  • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
  • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
  • Humira (adalimumab) treats many different autoimmune conditions.
  • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
Downsides
  • Orencia (abatacept) can be costly.
  • The IV infusion form of Orencia (abatacept) can cause a reaction, which ranges from a slight itching or warm feeling to more serious side effects such as low blood pressure and chest pain.
  • The IV infusion form of Orencia (abatacept) contains maltose, a type of sugar, that can give false high blood sugar readings with certain types of blood sugar monitors on the day of Orencia (abatacept) infusion. The self-injection subcutaneous form does not contain maltose. Talk to your doctor if you have diabetes.
  • If you need TNF inhibitors as part of your treatment, it is not recommended to take Orencia (abatacept). If you have COPD, you are at higher risk of side effects.
  • Orencia (abatacept) lowers your ability to fight infection. Your risk can increase if you take medications that lower your immune system or have an active infection. You may need to get tested for tuberculosis before starting Orencia (abatacept).
  • Not first-choice treatment for rheumatoid arthritis.
  • Humira (adalimumab) is an injection and not an oral medication.
  • Humira (adalimumab) is expensive because there's no generic available yet.
  • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
  • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
Used for
Dosage forms
  • Infusion
  • Injection
  • Injection
Price
Lowest price near you
$3912.13
Find instant savings
Lowest price near you
$4537.05
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
Not enough review data.Leave a review
182 
60%
think this treatment is worth it
51%
think this treatment works well
26%
think this treatment is a hassle

Have you used Humira (adalimumab)?

Leave a review
Side effects
10possible side effects
  • Headache
    18%
  • Common cold
    12%
  • Dizziness
    9%
  • Cough
    8%
  • Back pain
    7%
  • High blood pressure
    7%
  • Indigestion
    6%
  • Urinary tract infection
    6%
  • Rash
    4%
  • Pain in arms or legs
    3%
See more detailed side effects
10possible side effects
  • Upper airway infection
    17%
  • Headache
    12%
  • Rash
    12%
  • Sinus infection
    11%
  • Nausea
    9%
  • Injection site reactions
    8%
  • Urinary tract infection
    8%
  • Flu syndrome
    7%
  • Stomach pain
    7%
  • High cholesterol
    7%
See more detailed side effects
Risks and warnings
  • High risk of infections with TNF inhibitors

    Using TNF inhibitors

  • Immunosuppression and Infections

    Taking immunosuppressive medications

    ...and 2 more risk factors

  • More COPD side effects

    COPD

See more detailed risks and warnings
  • Serious infections

    Taking other immunosuppressant medications such as Kineret or Orencia

    ...and 3 more risk factors

  • Cancers

    Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)

    ...and 3 more risk factors

  • Heart problems

    History of heart failure

  • Nervous system effects

    Preexisting or recently acquired neurologic condition

See more detailed risks and warnings