Compare Orencia vs. Humira
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Orencia (abatacept) slows the progress of rheumatoid arthritis, but can also cause serious side effects.
Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.
- In a 2-year study that used IV Orencia (abatacept) with methotrexate, more than half of the people had remission and the majority felt significantly better.
- Helps minimize joint damage, lowers symptoms, and prevents future problems. People taking Orencia (abatacept) had no new joint damage after two years.
- Taking Orencia (abatacept) allows RA patients to use less prednisone, a steroid that has many side effects.
- You can give yourself Orencia (abatacept) subcutaneously on your own at home rather than visiting a clinic or hospital.
- Available in a prefilled autoinjector for convenient use.
- Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
- You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
- Humira (adalimumab) treats many different autoimmune conditions.
- Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
- Orencia (abatacept) can be costly.
- The IV infusion form of Orencia (abatacept) can cause a reaction, which ranges from a slight itching or warm feeling to more serious side effects such as low blood pressure and chest pain.
- The IV infusion form of Orencia (abatacept) contains maltose, a type of sugar, that can give false high blood sugar readings with certain types of blood sugar monitors on the day of Orencia (abatacept) infusion. The self-injection subcutaneous form does not contain maltose. Talk to your doctor if you have diabetes.
- If you need TNF inhibitors as part of your treatment, it is not recommended to take Orencia (abatacept). If you have COPD, you are at higher risk of side effects.
- Orencia (abatacept) lowers your ability to fight infection. Your risk can increase if you take medications that lower your immune system or have an active infection. You may need to get tested for tuberculosis before starting Orencia (abatacept).
- Not first-choice treatment for rheumatoid arthritis.
- Humira (adalimumab) is an injection and not an oral medication.
- Humira (adalimumab) is expensive because there's no generic available yet.
- Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
- You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
- Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
- Rheumatoid Arthritis
- Polyarticular Juvenile Idiopathic Arthritis
- Common cold12%
- Back pain7%
- High blood pressure7%
- Urinary tract infection6%
- Pain in arms or legs3%
- Upper airway infection17%
- Sinus infection11%
- Injection site reactions8%
- Urinary tract infection8%
- Flu syndrome7%
- Stomach pain7%
- High cholesterol7%
- High risk of infections with TNF inhibitors
Using TNF inhibitors
- Immunosuppression and Infections
Taking immunosuppressive medications
...and 2 more risk factors
- More COPD side effects
- Serious infections
Taking other immunosuppressant medications such as Kineret or Orencia
...and 3 more risk factors
Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)
...and 3 more risk factors
- Heart problems
History of heart failure
- Nervous system effects
Preexisting or recently acquired neurologic condition